Involvement of P-glycoprotein and Multidrug Resistance Associated Protein 1 in the Transport of Tanshinone IIB, a Primary Active Diterpenoid Quinone from the Roots of Salvia miltiorrhiza, Across the Blood-Brain Barrier

2007 ◽  
Vol 1 (3) ◽  
pp. 205-217 ◽  
Author(s):  
Zhi-Wei Zhou ◽  
Xiao Chen ◽  
Jun Liang ◽  
Xi-Yong Yu ◽  
Jing-Yuan Wen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Blood Brain Barrier ◽  
Salvia Miltiorrhiza ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain

The Blood-Brain Barrier: Roles of the Multidrug Resistance Transporter P-Glycoprotein

2007 ◽  
pp. 429-461
Author(s):  
Sandra Turcotte ◽  
Michel Demeule ◽  
Anthony Régina ◽  
Chantal Fournier ◽  
Julie Jodoin ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Multidrug Resistance Transporter

scholarly journals Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 ◽  
Vol 86 (2) ◽  
pp. 695-698 ◽  
Author(s):  
C. Cordon-Cardo ◽  
J. P. O'Brien ◽  
D. Casals ◽  
L. Rittman-Grauer ◽  
J. L. Biedler ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Multidrug Resistance Gene ◽  
P Glycoprotein ◽  
Blood Brain

scholarly journals The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Peng-Fei Yu ◽  
Wen-Yan Wang ◽  
Gaowa Eerdun ◽  
Tian Wang ◽  
Lei-Ming Zhang ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Salvia Miltiorrhiza ◽  
Water Soluble ◽  
Brain Barrier ◽  
Saline Control ◽  
Control Group ◽  
P Glycoprotein ◽  
Blood Brain ◽  
The Brain

Danshensu (3-(3, 4-dihydroxyphenyl) lactic acid), a water-soluble active component isolated from the root ofSalvia miltiorrhizaBunge, is widely used for the treatment of cerebrovascular diseases. The present study aims to investigate the role of P-glycoprotein in transport of Danshensu across the blood-brain barrier. Sprague-Dawley rats were pretreated with verapamil at a dose of 20 mg kg−1(verapamil group) or the same volume of normal saline (control group). Ninety minutes later, the animals were administrated with Danshensu (15 mg kg−1) by intravenous injection. At 15 min, 30 min, and 60 min after Danshensu administration, the levels of Danshensu in the blood and brain were detected by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The results showed that Danshensu concentrations in the brain of the rats pretreated with verapamil were significantly increased. In addition, the brain-plasma ratios of the group pretreated with verapamil were much higher than that of the control group. There was no difference in Danshensu level in plasma between the verapamil group and control group. The findings indicated that Danshensu can pass the blood-brain barrier, and P-glycoprotein plays an important role in Danshensu transportation in brain.

scholarly journals Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance–Associated Protein 2 at the Blood–Brain Barrier

2020 ◽  
Vol 128 (3) ◽  
pp. 037002 ◽  
Author(s):  
Ronald E. Cannon ◽  
Alicia C. Richards ◽  
Andrew W. Trexler ◽  
Christopher T. Juberg ◽  
Birandra Sinha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Blood Brain Barrier ◽  
Breast Cancer Resistance Protein ◽  
Brain Barrier ◽  
Cancer Resistance ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Resistance Protein
Sign in / Sign up

Export Citation Format

Share Document