scholarly journals Carotid Intima-Media Thickness in Patients with Psoriasis

2021 ◽  
Vol 15 (1) ◽  
pp. 45-51
Author(s):  
Hao Trong Nguyen ◽  
Phuong Thi Doan Vo ◽  
Nhi Thi Uyen Pham ◽  
Thang Anh Bui ◽  
Thao Phuong Nghiem
Keyword(s):  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Lipoprotein Cholesterol ◽  
External Carotid ◽  
Atherosclerotic Plaques ◽  
City Hospital ◽  
Media Thickness ◽  
The Mean

Introduction: Since the early 20th century, findings have demonstrated that psoriasis is frequently associated with atherosclerosis and cardiovascular diseases. The Carotid Intima-Media Thickness (CIMT) is a surrogate marker of atherosclerotic vascular disease. Objective: The aim of this study was to investigate the CIMT in patients with psoriasis and investigate its correlation with the clinical features. Methods: The present case-control study involved 70 patients with psoriasis who visited Ho Chi Minh City Hospital of Dermato-Venereology from September 2018 to April 2019 and 35 healthy subjects. Serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were measured in both groups. Linear Doppler scanning was performed to evaluate the CIMT of the common, internal, and external carotid arteries and the presence of atherosclerotic plaques. Results: The mean CIMT value in psoriasis patients was significantly higher than that of controls [0.59 mm (0.53 - 0.71) vs. 0.54 mm (0.52 - 0.62), respectively, p = 0.036]. Multiple linear regression analysis revealed a significant correlation between the CIMT and age (p = 0.043) and CIMT and the Psoriasis Area and Severity Index (p < 0.0001). Moreover, the mean number of atherosclerotic plaques in psoriasis patients was significantly higher than that in controls [0.27 ± 0.68 vs. 0.03 ± 0.17, respectively, p = 0.035]. Conclusion: Elderly patients with severe psoriasis should be evaluated carefully regarding CIMT and atherosclerotic plaques, as these signs are representative of increased cardiovascular risk.

Carotid intima media thickness in obese children: is there an association with hyperlipidemia?

2016 ◽  
Vol 29 (2) ◽  
Author(s):  
Zehra Esra Önal ◽  
Levent Soydan ◽  
Hatice Eren Öztürk ◽  
Çiğdem Sağ ◽  
Tamay Gürbüz ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Control Group ◽  
Study Group ◽  
Obese Children ◽  
Media Thickness ◽  
The Mean

AbstractWe aimed to evaluate the association between hyperlipidemia and carotid intima media thickness in obese children, compared to non-obese ones.Two hundred (110 girls, 90 boys) children aged between 6 and 15 years participated in this study. The obese group included 53 girls, 47 boys whose body mass indices (BMI) above 95th percentile, the control group included 57 girls, 43 boys who had normal weight. Fasting total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) levels were measured. Carotid intima media thickness (cIMT) was performed with neck ultrasound.The median thickness of right, left and mean carotis intima media were statistically higher in the study group, compared to the control group. The mean cholesterol, triglyceride, HDL-C, LDL-C levels of the study group were statistically higher, compared to the control group. There was no relationship between BMI and left carotis intima media thickness, but there was statistically significant relationship between BMI and right, mean cIMTs in the study group. There was no correlation between serum lipid levels and cIMTs in the study group. The mean atherogenic index of the study group was statistically higher, compared to the control group. There was no statistical correlation between atherogenic index and cIMTs in both of the groups.We observed that obese children had higher carotis intima media thicknesses. Carotis intima media thickness related to obesity can play an important role in future pre-atherosclerotic changes. Large population based studies are required to confirm this associaton.

scholarly journals Cardiovascular risk factors and their association with carotid intima media thickness in children in Western India

2018 ◽  
Vol 6 (5) ◽  
pp. 1525
Author(s):  
Ashish Kumar Jain ◽  
Sameer Dani ◽  
Parul Jain
Keyword(s):  
Risk Factors ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Lipoprotein Cholesterol ◽  
Calorie Intake ◽  
Western India ◽  
Fat Intake ◽  
Media Thickness ◽  
Cv Disease

Background: Cardiovascular disease occurs in early in Indians risk factors of which may start from childhood. Objective was to identify CV risk factors in children and study their association with carotid intima media thickness.Methods: In this cross-sectional study, we studied children aged 4 to 14 years visiting our institute for routine health check-up. Data was collected on demographics, clinical and biochemical parameters. All patient underwent electrocardiographic, 2-D echocardiography examination. Carotid intima media thickness (CMT) was observed by carotid ultrasound.Results: In 378 children enrolled in the study, mean age was 9.1±2.6 years with 74.6% being males. Mean body mass index was 18.7±3.9 kg/m2. Among various CV risk factors, dyslipidemia (46.6%) was most common followed by family history of premature CV disease (9.5%), hypertension (4.49%), obesity (3.17%), smoking (1.05%). High dietary fat intake was seen in 22.2% cases. CMT showed significant association with age (p=0.027), BMI (p=0.031), systolic (p=0.026) and diastolic (p=0.036) blood pressure, high-density lipoprotein cholesterol levels (p=0.001), and low-density lipoprotein cholesterol (p=0.047). No association with fat intake or total calorie intake was observed.Conclusions: Dyslipidemia along other risk factors can be present as CV risk factor from early childhood. Screening of children for such risk factors to mitigate the risk of atherosclerotic CV disease in adulthood.

scholarly journals Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2631 ◽  
Author(s):  
Serafi Cambray ◽  
Merce Ibarz ◽  
Marcelino Bermudez-Lopez ◽  
Manuel Marti-Antonio ◽  
Milica Bozic ◽  
...  
Keyword(s):  
Linear Regression ◽  
Cardiovascular Health ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Atherosclerotic Cardiovascular Disease ◽  
Effect Modifier ◽  
Media Thickness ◽  
Lipid Parameters

Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with worse cardiovascular outcomes. Magnesium (Mg) is a divalent cation whose homeostasis is altered in CKD. Furthermore, Mg levels have been associated with cardiovascular health. The present study aims to understand the relationships of Mg and lipid parameters with atherosclerosis in CKD. In this analysis, 1754 participants from the Observatorio Nacional de Atherosclerosis en Nefrologia (NEFRONA) cohort were included. Carotid intima media thickness (cIMT) was determined in six arterial territories, and associated factors were investigated by linear regression. cIMT correlated positively with being male, Caucasian, a smoker, diabetic, hypertensive, dyslipidemic and with increased age, BMI, and triglyceride levels, and negatively with levels of HDL cholesterol. First-order interactions in linear regression analysis showed that Mg was an effect modifier on the influence of lipidic parameters. Thus, cIMT predicted values were higher when triglycerides or LDL levels were high and Mg levels were low. On the contrary, when Mg levels were high, this effect disappeared. In conclusion, Mg acts as an effect modifier between lipidic parameters and atherosclerotic cardiovascular disease. Therefore, Mg levels, together with lipidic parameters, should be taken into account when assessing atherosclerotic risk.

Abstract P105: Associations Of Subclasses, Content And Function Metrics Of High-density Lipoprotein With Carotid Intima-media Thickness In Women Transitioning Through Menopause Swan Hdl And Swan Heart Studies

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Samar R El Khoudary ◽  
Xirun Chen ◽  
Maria M Brooks ◽  
Jeff Billheimer ◽  
Trevor Orchard ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Midlife Women ◽  
Lipoprotein Cholesterol ◽  
Cvd Risk ◽  
Age At Menopause ◽  
Media Thickness ◽  
Menopause Transition

Objective: Higher levels of high-density lipoprotein cholesterol (HDL-C) may not always be cardio-protective in midlife women. Novel metrics of HDL including nuclear magnetic resonance (NMR) spectroscopy subclasses (large, medium and small HDL particles (HDL-P), and size), HDL content of phospholipids (HDL-PL) and triglycerides (HDL-Tg), and HDL function as measured by cholesterol efflux capacity (HDL-CEC) show strong associations with cardiovascular disease (CVD) risk beyond HDL-C. Women experience increases in carotid Intima-media thickness (cIMT), a subclinical measure of atherosclerosis, over the menopause transition. Associations of novel metrics of HDL with cIMT have not been well characterized in midlife women. Our objective was to assess the associations of HDL subclasses, HDL-PL, HDL-Tg, and HDL-CEC with cIMT and to determine whether these associations vary by age at menopause. Design: We assessed 303 women (at baseline: age 51.0 ± 2.8 years; 67.8% White and 32.2% Black; 56.6% Pre-/Early perimenopausal) who had HDL metrics and cIMT measured once (N=37 [12%]) or twice (N=266 [88%]) over the menopause transition. Age at menopause was observed prospectively among 73% of women (defined as no menses for 12 consecutive months) and imputed among the rest. Linear mixed effect models were used to individually assess the association of each HDL metric with cIMT, and to test whether the association varied by age at menopause (<50, 50-53, >53 years old). Final models were adjusted for race, education, and time varying: age, systolic blood pressure, body mass index, menopausal status, triglycerides, low density lipoprotein cholesterol and HDL-C. Results: In unadjusted analyses, higher concentrations of large HDL-P, medium HDL-P, HDL-PL, and HDL-CEC, and larger HDL size, and lower concentrations of small HDL-P were associated with lower cIMT; all p <0.05. In final models, only associations of medium HDL-P (p=0.008) and HDL-PL (p=0.005) with cIMT remained statistically significant. Age at menopause modified associations of HDL-Tg with cIMT in both unadjusted and final models (p=0.05 for both); in the final model, per 1 SD unit increase in HDL-Tg, women with age at menopause >53 had thicker cIMT(β(SE): 6.72(6.27) μm) than those with age at menopause <50 (β(SE): -17.88(8.48) μm), p for comparison=0.01. Conclusions: In midlife women, higher concentrations of medium HDL-P and greater content of HDL phospholipids were associated with thinner cIMT beyond traditional CVD risk factors including HDL-C. Associations of HDL triglycerides content with thicker cIMT was more pronounced in women who reached menopause at older ages. Findings support utilizing other metrics of HDL rather than HDL-C to better characterize CVD risk in midlife women.

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