Stem Cell Function, Self-Renewal, Heterogeneity, and Regenerative Potential in Skeletal Muscle Stem Cells

2012 ◽  
Vol 2 (1) ◽  
pp. 11-21
Author(s):  
Silvia Cristini ◽  
Giulio Alessandri ◽  
Francesco Acerbi ◽  
Daniela Tavian ◽  
Eugenio A. Parati ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Function ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

Stem Cell Function, Self-Renewal, Heterogeneity, and Regenerative Potential in Skeletal Muscle Stem Cells

2012 ◽  
Vol 2 (1) ◽  
pp. 11-21
Author(s):  
Silvia Cristini ◽  
Giulio Alessandri ◽  
Francesco Acerbi ◽  
Daniela Tavian ◽  
Eugenio A. Parati ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Function ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

An oscillatory network controlling self-renewal of skeletal muscle stem cells

2021 ◽  
pp. 112933
Author(s):  
Ines Lahmann ◽  
Yao Zhang ◽  
Katharina Baum ◽  
Jana Wolf ◽  
Carmen Birchmeier
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Oscillatory Network ◽  
Skeletal Muscle Stem Cells

scholarly journals Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment

2021 ◽  
Author(s):  
Felicia Lazure ◽  
Rick Farouni ◽  
Korin Sahinyan ◽  
Darren M. Blackburn ◽  
Aldo Hernandez-Corchado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Tissue Regeneration ◽  
Adult Stem Cells ◽  
Cell Function ◽  
Chromatin Accessibility ◽  
Muscle Stem Cells ◽  
Age Related ◽  
A Genome ◽  
Skeletal Muscle Stem Cells

Adult stem cells are indispensable for tissue regeneration. Tissue-specific stem cells reside in a specialized location called their niche, where they are in constant cross talk with neighboring niche cells and circulatory signals from their environment. Aging has a detrimental effect on the number and the regenerative function of various stem cells. However, whether the loss of stem cell function is a cause or consequence of their aging niche is unclear. Using skeletal muscle stem cells (MuSCs) as a model, we decouple cell-intrinsic from niche-mediated extrinsic effects of aging on their transcriptome. By combining in vivo MuSC heterochronic transplantation models and computational methods, we show that on a genome-wide scale, age-related altered genes fall into two distinct categories regarding their response to the niche environment. Genes that are inelastic in their response to the niche exhibit altered chromatin accessibility and are associated with differentially methylated regions (DMRs) between young and aged cells. On the other hand, genes that are restorable by niche exposure exhibit altered transcriptome but show no change in chromatin accessibility or DMRs. Taken together, our data suggest that the niche environment plays a decisive role in controlling the transcriptional activity of MuSCs, and exposure to a young niche can reverse approximately half of all age-associated changes that are not epigenetically encoded. The muscle niche therefore serves as an important therapeutic venue to mitigate the negative consequence of aging on tissue regeneration.

scholarly journals Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration

Cells ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 183 ◽  
Author(s):  
David Lee ◽  
Akshay Bareja ◽  
David Bartlett ◽  
James White
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Muscle Regeneration ◽  
Immune Cell ◽  
Regenerative Capacity ◽  
Adult Skeletal Muscle ◽  
Muscle Stem Cells ◽  
Age Related ◽  
Skeletal Muscle Stem Cells

Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function.

scholarly journals Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells

Stem Cells ◽  
2017 ◽  
Vol 36 (3) ◽  
pp. 458-466 ◽  
Author(s):  
SiewHui Low ◽  
Josephine L. Barnes ◽  
Peter S. Zammit ◽  
Jonathan R. Beauchamp
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Notch 3 ◽  
Skeletal Muscle Stem Cells

scholarly journals Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells

2011 ◽  
Vol 25 (8) ◽  
pp. 789-794 ◽  
Author(s):  
A. H. Juan ◽  
A. Derfoul ◽  
X. Feng ◽  
J. G. Ryall ◽  
S. Dell'Orso ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

scholarly journals Cyclin D3 critically regulates the balance between self-renewal and differentiation in skeletal muscle stem cells

Stem Cells ◽  
2013 ◽  
Vol 31 (11) ◽  
pp. 2478-2491 ◽  
Author(s):  
Giulia De Luca ◽  
Roberta Ferretti ◽  
Marco Bruschi ◽  
Eleonora Mezzaroma ◽  
Maurizia Caruso
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Cyclin D3 ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

scholarly journals Perspectives on skeletal muscle stem cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
F. Relaix ◽  
M. Bencze ◽  
M. J. Borok ◽  
A. Der Vartanian ◽  
F. Gattazzo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Regenerative Medicine ◽  
Cellular Heterogeneity ◽  
Self Renewal ◽  
Muscle Disorders ◽  
Muscle Stem Cells ◽  
Complex Regulation ◽  
Definition Of ◽  
Skeletal Muscle Stem Cells

AbstractSkeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and Galert states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine.

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