Efficient Wormlike Micelles for the Controlled Delivery of Anticancer Drugs

2020 ◽  
Vol 10 ◽  
Author(s):  
P. Sharmiladevi ◽  
M. Breghatha ◽  
K. Dhanavardhini ◽  
R. Priya ◽  
Koyeli Girigoswami ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Sodium Salicylate ◽  
Controlled Delivery ◽  
Self Organization ◽  
Wormlike Micelles ◽  
Delivery Vehicle ◽  
Killing Effect ◽  
Salicylate Concentration ◽  
Doxorubicin Release ◽  
Cell Killing Effect

Background: In order to improve the solubility and carrying capacity of anticancer drugs to the targeted cells a potential nanoformulation is needed Objective: A viscoelastic wormlike micelles (WLM) have been reported in the present study. Methods: The elongated and flexible aggregates of amphiphiles were formed due to the self-organization when the amphiphile concentration was fixed at its CMC and the sodium salicylate concentration was varied for the optimization Results: The stable structure, higher density, higher viscosity and potent cell killing effect at lower concentration of drug were observed at 480 μM concentration of sodium salicylate. The doxorubicin release profile showed a clear sustained release after 20 h and 82% of the drug has been released after 72 h. Conclusion: Therefore, the designed WLMs can be used as efficient drug delivery vehicle for the treatment of cancer

Multifunctional phase-change hollow mesoporous Prussian blue nanoparticles as a NIR light responsive drug co-delivery system to overcome cancer therapeutic resistance

2017 ◽  
Vol 5 (34) ◽  
pp. 7051-7058 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Zhengbao Zha
Keyword(s):  
Phase Change ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Resistance ◽  
Killing Effect ◽  
Nir Light ◽  
Prussian Blue Nanoparticles ◽  
Delivery Platform ◽  
Cell Killing Effect

A versatile NIR light responsive co-delivery platform of both hydrophobic and hydrophilic anticancer drugs has been developed here for overcoming adaptive therapeutic resistance of cancer cells and enhancing cell-killing effect.

Difference by Frequencies on Cell Killing Effect by Superposing Low Frequency on High-Frequency Bipolar Burst Pulse

2020 ◽  
Vol 48 (12) ◽  
pp. 4365-4373
Author(s):  
Hiromi Sato ◽  
Yasushi Minamitani ◽  
Gen Urabe ◽  
Taichi Kamezaki ◽  
Shuji Okamoto ◽  
...  
Keyword(s):  
High Frequency ◽  
Low Frequency ◽  
Cell Killing ◽  
Killing Effect ◽  
Burst Pulse ◽  
Cell Killing Effect

scholarly journals Luminescent CaTiO3:Yb,Er nanofibers co-conjugated with Rose Bengal and gold nanorods for potential synergistic photodynamic/photothermal therapy

2017 ◽  
Vol 5 (26) ◽  
pp. 5128-5136 ◽  
Author(s):  
Yike Fu ◽  
Heng Liu ◽  
Zhaohui Ren ◽  
Xiang Li ◽  
Jie Huang ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Gold Nanorods ◽  
Rose Bengal ◽  
Photothermal Therapy ◽  
Cell Killing ◽  
Killing Effect ◽  
Photothermal Phenomenon ◽  
Cell Killing Effect

CaTiO3:Yb,Er nanofibers, co-conjugated with Rose Bengal and gold nanorods, enable a synergistic photodynamic/photothermal phenomenon for superior cancer cell killing effect.

Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams

Gene Therapy ◽  
2015 ◽  
Vol 23 (1) ◽  
pp. 50-56 ◽  
Author(s):  
M Kano ◽  
K Matsushita ◽  
B Rahmutulla ◽  
S Yamada ◽  
H Shimada ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ion Beams ◽  
Cell Killing ◽  
Killing Effect ◽  
Carbon Ion ◽  
Cell Killing Effect
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