Adipose Tissue-Derived Multi-lineage Progenitor Cells as a Promising Tool for In Situ Stem Cell Therapy

2012 ◽  
Vol 1 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Hanayuki Okura ◽  
Ayami Saga ◽  
Mayumi Soeda ◽  
Akihiro Ichinose ◽  
Akifumi Matsuyama
2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Luciana Lamarão Damous ◽  
Juliana Sanajotti Nakamuta ◽  
Ana Elisa Teófilo Saturi de Carvalho ◽  
José Maria Soares-Jr ◽  
Manuel de Jesus Simões ◽  
...  

2016 ◽  
Vol 311 (1) ◽  
pp. H207-H218 ◽  
Author(s):  
Evelien Nollet ◽  
Vicky Y. Hoymans ◽  
Amaryllis H. Van Craenenbroeck ◽  
Christiaan J. Vrints ◽  
Emeline M. Van Craenenbroeck

The initial promising prospect of autologous bone marrow-derived stem cell therapy in the setting of cardiovascular diseases has been overshadowed by functional shortcomings of the stem cell product. As powerful epigenetic regulators of (stem) cell function, microRNAs are valuable targets for novel therapeutic strategies. Indeed, modulation of specific miRNA expression could contribute to improved therapeutic efficacy of stem cell therapy. First, this review elaborates on the functional relevance of miRNA dysregulation in bone marrow-derived progenitor cells in different cardiovascular diseases. Next, we provide a comprehensive overview of the current evidence on the effect of specific miRNA modulation in several types of progenitor cells on cardiac and/or vascular regeneration. By elaborating on the cardioprotective regulation of progenitor cells on cardiac miRNAs, more insight in the underlying mechanisms of stem cell therapy is provided. Finally, some considerations are made regarding the potential of circulating miRNAs as regulators of the miRNA signature of progenitor cells in cardiovascular diseases.


2013 ◽  
Vol 54 (5) ◽  
pp. 1293 ◽  
Author(s):  
Jae Woo Jung ◽  
Minsuk Kwon ◽  
Jae Chol Choi ◽  
Jong Wook Shin ◽  
In Won Park ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70170 ◽  
Author(s):  
Alexandra Sémont ◽  
Christelle Demarquay ◽  
Raphaëlle Bessout ◽  
Christelle Durand ◽  
Marc Benderitter ◽  
...  

2005 ◽  
Vol 23 (2) ◽  
pp. 78-83 ◽  
Author(s):  
Smita Agrawal ◽  
David V. Schaffer

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