3D Printing & Pharmaceutical Manufacturing: Opportunities and Challenges

2016 ◽  
Vol 5 (01) ◽  
pp. 4723 ◽  
Author(s):  
Bhusnure O. G.* ◽  
Gholve V. S. ◽  
Sugave B. K. ◽  
Dongre R. C. ◽  
Gore S. A. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
3D Printing ◽  
Computer Aided Design ◽  
Patient Specific ◽  
Computer Design ◽  
3D Scaffolds ◽  
Engineering Research ◽  
Advantages And Disadvantages ◽  
Computer Aided

Many researchers have attempted to use computer-aided design (C.A.D) and computer-aided manufacturing (CAM) to realize a scaffold that provides a three-dimensional (3D) environment for regeneration of tissues and organs. As a result, several 3D printing technologies, including stereolithography, deposition modeling, inkjet-based printing and selective laser sintering have been developed. Because these 3D printing technologies use computers for design and fabrication, and they can fabricate 3D scaffolds as designed; as a consequence, they can be standardized. Growth of target tissues and organs requires the presence of appropriate growth factors, so fabrication of 3Dscaffold systems that release these biomolecules has been explored. A drug delivery system (D.D.S) that administrates a pharmaceutical compound to achieve a therapeutic effect in cells, animals and humans is a key technology that delivers biomolecules without side effects caused by excessive doses. 3D printing technologies and D. D. Ss have been assembled successfully, so new possibilities for improved tissue regeneration have been suggested. If the interaction between cells and scaffold system with biomolecules can be understood and controlled, and if an optimal 3D tissue regenerating environment is realized, 3D printing technologies will become an important aspect of tissue engineering research in the near future. 3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fuelled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. Until recently, tablet designs had been restricted to the relatively small number of shapes that are easily achievable using traditional manufacturing methods. As 3D printing capabilities develop further, safety and regulatory concerns are addressed and the cost of the technology falls, contract manufacturers and pharmaceutical companies that experiment with these 3D printing innovations are likely to gain a competitive edge. This review compose the basics, types & techniques used, advantages and disadvantages of 3D printing

scholarly journals Patient-Specific Coronary Artery 3D Printing Based on Intravascular Optical Coherence Tomography and Coronary Angiography

Complexity ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Chenxi Huang ◽  
Yisha Lan ◽  
Sirui Chen ◽  
Qing Liu ◽  
Xin Luo ◽  
...  
Keyword(s):  
Coronary Artery ◽  
3D Printing ◽  
Coronary Angiography ◽  
Coronary Arteries ◽  
Computer Aided Design ◽  
Patient Specific ◽  
3D Printing Technology ◽  
Vessel Lumen ◽  
Computer Aided ◽  
Aided Design

Despite the new ideas were inspired in medical treatment by the rapid advancement of three-dimensional (3D) printing technology, there is still rare research work reported on 3D printing of coronary arteries being documented in the literature. In this work, the application value of 3D printing technology in the treatment of cardiovascular diseases has been explored via comparison study between the 3D printed vascular solid model and the computer aided design (CAD) model. In this paper, a new framework is proposed to achieve a 3D printing vascular model with high simulation. The patient-specific 3D reconstruction of the coronary arteries is performed by the detailed morphological information abstracted from the contour of the vessel lumen. In the process of reconstruction which has 5 steps, the morphological details of the contour view of the vessel lumen are merged along with the curvature and length information provided by the coronary angiography. After comparing with the diameter of the narrow section and the diameter of the normal section in CAD models and 3D printing model, it can be concluded that there is a high correlation between the diameter of vascular stenosis measured in 3D printing models and computer aided design models. The 3D printing model has high-modeling ability and high precision, which can represent the original coronary artery appearance accurately. It can be adapted for prevascularization planning to support doctors in determining the surgical procedures.

Computer-Aided Tissue Engineering in Whole Bone Replacement Treatment

2005 ◽  
Author(s):  
M. Wettergreen ◽  
B. Bucklen ◽  
W. Sun ◽  
M. A. K. Liebschner
Keyword(s):  
Tissue Engineering ◽  
Vertebral Body ◽  
Computer Aided Design ◽  
Building Blocks ◽  
The Body ◽  
Artificial Substrates ◽  
Design Parameters ◽  
Patient Specific ◽  
Cellular Interactions ◽  
Computer Aided

Tissue engineering is developing into a less speculative field involving the careful interplay of numerous design parameters and multi-disciplinary professionals. Problem solving abilities and state of the art research tools are required to develop solutions for a wide variety of clinical issues. One area of particular interest is orthopaedic biomechanics, a field that is responsible for the treatment of over 700,000 vertebral fractures in the U.S alone last year. Engineers are currently lacking the technology and knowledge required to govern the subsistence of cells in vivo, let alone the knowledge to create a functional tissue replacement for a whole organ. Despite this, advances in Computer Aided Tissue Engineering (CATE) are continually growing. Using a combinatory approach to scaffold design, patient-specific implants may be constructed. Computer aided design (CAD), optimization of geometry using voxel finite element models or other optimization routines, creation of a library of architectures with specific material properties, rapid prototyping, and determination of a defect site using imaging modalities highlight the current availability of design resources. Our study represents a patient specific approach for constructing a complete vertebral body via building blocks. Though some of the methods described cannot be realized with current technology, namely complete construction of the vertebral body via FDM, the necessary advances are not far off. Computing power and CAD programs need to improve slightly to allow the rapid generation of complex models that would ease the fabrication of an appropriate number of building blocks. The main bottleneck of the process described in this study is the general lack of knowledge of human mechanobiology and the role of cellular interactions on artificial substrates including immune responses, and foreign body reactions. Assuming these biological parameters can be identified, a scaffold may be designed with a proper pore size and interconnectivity, microstructure, degradation rate, and surface chemistry. The advantage of the outlined process lies in adjustment of the vertebral compliance first, to ensure adequate load transfer, an important property for vertebral replacement. Subsequently, net biological properties can be fine tuned by simply scaling the final construct. Mixing and matching of geometries may be utilized to design asymmetric scaffolds, or scaffolds that exhibit a discontinuous microstructural stiffness with the goal of accentuating fluid flow. Finally, while these techniques lend themselves to the formulation of bone constructs, they can be used for other parts of the body as well that do not require load-bearing support.

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

Constraints and limitations of concrete 3D printing in architecture

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Chien-Ho Ko
Keyword(s):  
3D Printing ◽  
Manufacturing Process ◽  
Computer Aided Design ◽  
Research Approach ◽  
Layer By Layer ◽  
Content Type ◽  
Improve Design ◽  
Study Results ◽  
Computer Aided ◽  
Property Control

Purpose Additive manufacturing of concrete (AMoC) is an emerging technology for constructing buildings. However, due to the nature of the concrete property and constructing buildings in layers, constraints and limitations are encountered while applying AMoC in architecture. This paper aims to analyze the constraints and limitations that may be encountered while using AMoC in architecture. Design/methodology/approach A descriptive research approach is used to conduct this study. First, basic notions of AMoC are introduced. Then, challenges of AMoC, including hardware, material property, control and design, are addressed. Finally, strategies that may be used to overcome the challenges are discussed. Findings Factors influencing the success of AMoC include hardware, material, control methods, manufacturing process and design. Considering these issues in the early design phase is crucial to achieving a successful computer-aided design (CAD)/computer-aided manufacturing (CAM) integration to bring CAD and CAM benefits into the architecture industry. Originality/value In three-dimensional (3D) printing, objects are constructed layer by layer. Printing results are thus affected by the additive method (such as toolpath) and material properties (such as tensile strength and slump). Although previous studies attempt to improve AMoC, most of them focus on the manufacturing process. However, a successful application of AMoC in architecture needs to consider the possible constraints and limitations of concrete 3D printing. So far, research on the potential challenges of applying AMoC in architecture from a building lifecycle perspective is still limited. The study results of this study could be used to improve design and construction while applying AMoC in architecture.

scholarly journals Upgrade and Repair of the Instrumentation Equipment on the ISS RS Simulators Using FDM 3D Printing Technology.

2021 ◽  
pp. 97-110
Author(s):  
V.V. Batrakov ◽  
A.I. Krylov ◽  
V.N. Saev ◽  
B.N. Nefyodov ◽  
V.M. Novichkov ◽  
...  
Keyword(s):  
3D Printing ◽  
Computer Aided Design ◽  
Cad Tools ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Computer Aided ◽  
Aided Design

The paper presents space simulators (SS), types of instrumentation equipment installed on the workplaces of the space simulators operators (SSOPW), multi-functional display panel (MFDP), computer-aided design (CAD) tools, 3D printing technologies.

3D PRINTING OF PHARMACEUTICALS – LEADING TREND IN PHARMACEUTICAL INDUSTRY AND FUTURE PERSPECTIVES

2020 ◽  
pp. 10-16
Author(s):  
SHANKHADIP NANDI
Keyword(s):  
Drug Delivery ◽  
Pharmaceutical Industry ◽  
3D Printing ◽  
Computer Aided Design ◽  
Release Kinetics ◽  
Research Work ◽  
Economic Benefits ◽  
Pharmaceutical Products ◽  
Dosage Forms ◽  
Fused Deposition

3D printing technology is a rapid prototyping process based on computer-aided design software that is proficient to construct solid objects with various geometrics by depositing numerous layers in a sequence. The major advantages of three-dimensional printing (3DP) technology over the traditional manufacturing of pharmaceuticals include the customization of medications with individually adjusted doses, on-demand tailored manufacturing, unprecedented flexibility in the design, manufacturing of complex and sophisticated solid dosage forms, and economic benefits. Recently, many researchers have been invested their efforts in applying 3DP technology to the pharmaceutical development of drug products and different drug delivery systems. Selective laser sintering, fused deposition modeling, semi-solid extrusion, stereolithography, etc., are the multiple 3DP technologies that can be established in several customized and programmable medicines. Sublingual, orodispersible, and fast-dissolving drug delivery formulations by 3DP technology have been already manufactured. Controlled-release formulations with different characteristics, doughnut-shaped multi-layered tablets with linear release kinetics, and drug-loaded tablets with modified-release characteristics are recently fabricated using 3DP. However, few 3DP methods produce uneven shapes of dosage forms and comparatively porous structures. Cost of transition, adaptation to the existing facility, achieving regulatory approval, etc., are the present challenges that can restrict the extensive application of 3DP technology to pharmaceutical products. Intense research work for modifying the 3DP methods is simultaneously sustained for by-passing the flaws and current limitations of this technology. 3DP technology can act as a convenient and potential tool for the pharmaceutical industry which will set a revolutionary manufacturing style in the near future to facilitate patient-centered health care.

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