Predictive Value of Major Inflammatory Markers in Complete Blood Count for Short-Term Prognosis in Patients with Acute Carbon-monoxide Poisoning

2018 ◽  
Vol 09 (03) ◽  
Author(s):  
Weiqiang Wang ◽  
Jincheng Cheng ◽  
Kai Wang ◽  
Jun Zhang
Keyword(s):  
Carbon Monoxide ◽  
Predictive Value ◽  
Inflammatory Markers ◽  
Blood Count ◽  
Complete Blood Count ◽  
Carbon Monoxide Poisoning ◽  
Short Term ◽  
Acute Carbon Monoxide Poisoning

How much apoptosis does carbon monoxide poisoning cause? Primary clinical soluble TWEAK protein level study

2019 ◽  
Vol 38 (8) ◽  
pp. 974-982 ◽  
Author(s):  
N Dindar Badem ◽  
E Cömertpay ◽  
F Coşkun
Keyword(s):  
Carbon Monoxide ◽  
Peripheral Blood ◽  
Protein Level ◽  
Cell Apoptosis ◽  
Predictive Value ◽  
Complete Blood Count ◽  
Carbon Monoxide Poisoning ◽  
Control Group ◽  
Co Poisoning ◽  
Arterial Blood

Carbon monoxide (CO) is an important cause of deaths via poisoning. CO poisoning causes inhibition of O2 transport and development of tissue hypoxia, which then causes cell apoptosis. A significant indicator of cell apoptosis, soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) protein, is important for the stimulation of apoptosis. The primary purpose of this study is to determine whether apoptosis occurs during acute CO poisoning and to show that sTWEAK protein is an indicator of apoptosis that can be analyzed as a marker in the peripheral blood sample. The secondary aim is to determine the diagnostic and prognostic values of sTWEAK protein. The study was performed prospectively on 43 patients with CO poisoning and 30 healthy volunteer control individuals. The anamneses were taken from all patients, who also underwent physical examination. Complete blood count, biochemical markers, cardiac enzymes, and arterial blood gas measurements were analyzed. All the patients’ sTWEAK protein levels were also analyzed. The sTWEAK protein level of patients with CO poisoning was 2278 pg/mL (1197–7234), while the level of the control group was 1609 pg/mL (310–3721). The patients’ sTWEAK levels were significantly higher than the controls (area under the curve: 0.77 (0.66–0.89); p < 0.001), and the cutoff value was determined as 1895.50 pg/mL. The cutoff level had a sensitivity of 74.4%, a specificity of 76.7%, a positive predictive value of 82.0%, and a negative predictive value of 67.6%. sTWEAK is a significant indicator of apoptosis in CO poisoning that can be analyzed in the peripheral blood. However, further clinical trials are needed in terms of prognostic criteria.

scholarly journals Can Hematological Parameters Play a Role in the Differential Diagnosis of Adrenal Tumors?

Uro ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 39-44
Author(s):  
Mehmet Gürkan Arıkan ◽  
Göktan Altuğ Öz ◽  
Nur Gülce İşkan ◽  
Necdet Süt ◽  
İlkan Yüksel ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Markers ◽  
Blood Count ◽  
Complete Blood Count ◽  
Low Cost ◽  
Easy Access ◽  
Adrenal Tumors ◽  
Tumor Diameter ◽  
Lymphocyte Ratio ◽  
Significant Difference

There have been few studies reported with conflicting results in the use of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), redcell-distribution-width (RDW), etc. for predicting prognosis and differential diagnosis of adrenal tumors. The aim of this study is to investigate the role of inflammatory markers through a complete blood count, which is an easy access low-cost method, for the differential diagnosis of adrenocortical adenoma (ACA), adrenocortical carcinoma (ACC), and pheochromocytoma. The data of patients who underwent adrenalectomy between the years of 2010–2020 were retrospectively analyzed. Systemic hematologic inflammatory markers based on a complete blood count such as neutrophil ratio (NR), lymphocyte ratio (LR), NLR, PLR, RDW, mean platelet volume (MPV), and maximum tumor diameter (MTD) were compared between the groups. A statistically significant difference was found between the three groups in terms of PLR, RDW, and MTD. With post-hoc tests, a statistically significant difference was found in PLR and MTD between the ACA and ACC groups. A statistically significant difference was found between the ACA and pheochromocytoma groups in PLR and RDW values. In conclusion, it could be possible to plan a more accurate medical and surgical approach using PLR and RDW, which are easily calculated through an easy access low-cost method such as a complete blood count, together with MTD in the differential diagnosis of ACC, ACA, and pheochromocytoma.

scholarly journals Bilateral brachial plexus injury following acute carbon monoxide poisoning

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Mounia Rahmani ◽  
Halima Belaidi ◽  
Maria Benabdeljlil ◽  
Wafa Bouchhab ◽  
Nadia El Jazouli ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Brachial Plexus ◽  
Brachial Plexus Injury ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning

Cardiovascular, metabolic and neurologic effects of acute carbon monoxide poisoning in the rat

1989 ◽  
Vol 45 (2-3) ◽  
pp. 207-213 ◽  
Author(s):  
David G. Penney ◽  
Kuldeep Verma ◽  
Julie A. Hull
Keyword(s):  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning

ACCIDENTAL ACUTE CARBON-MONOXIDE POISONING

The Lancet ◽  
1940 ◽  
Vol 236 (6118) ◽  
pp. 677-679
Author(s):  
J MCMICHAEL
Keyword(s):  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Acute Carbon Monoxide Poisoning
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