EDITORIAL ANTIBIOTIC STEWARDSHIP, ANTIMICROBIALS RESISTANCE, AND RATIONAL USE OF MEDICINE   	 This editorial highlights the antibiotic stewardship, antimicrobials resistance, and rational use of medicine. Photo by Freedigitalphotos By Mainul Haque  	PDF  NANO IMAGING: A NOVEL ERA OF CANCER NANO MEDICINE IN 21ST CENTURY   	 The present editorial discusses about Nano imaging: A novel era of cancer Nano medicine in 21st century. Photo by The Scientist Magazine By Behzad Foroutan  	PDF RESEARCH UNGUIDED BRONCHOSCOPIC BIOPSY: DOES YIELD INCREASE WITH OPERATOR EXPERIENCE   	 This study aims to determine the effect of on- job experience on the yield of unguided bronchoscopic biopsies. Photo by Freedigitalphotos By Tyagi Rahul, Chawla Naveen,	Gurjeet Singh Chowdhary, Hande Vivek  	ABSTRACT 	PDF  ULTRASOUND CERVICAL LENGTH IN PREDICTING PRETERM BIRTH   	 The aim of this study was to evaluate the importance of cervical length measured in the first trimester (11–14 Weeks of amenorrhea “WA”) and the second trimester (20–24 Weeks of amenorrhea” WA”) in an asymptomatic population of singleton pregnancies to assess the risk of spontaneous preterm birth compared to the digital assessment. Photo by Freedigitalphotos By Achour Radhouane, Ben Jemaa Nadia,	Ksibi Imen,	Meriem Cheour,	Bouriel Ines,	Ayari Feirouz,	Samia Kacem,	Neji Khaled  	ABSTRACT 	PDF  PATIENT AGE AT DIAGNOSIS AND THE CLINICOPATHOLOGICAL FEATURES OF BREAST CANCER IN WOMEN

Abstract Objectives Nearly 100% of North American women have detectable levels of flame retardants such as polybrominated diphenyl ethers (PBDEs) in their plasma. These molecules have structural homology to thyroid hormones and may function as endocrine disruptors. Thyroid dysfunction has previously been associated with increased risk for preterm birth. Therefore, we conducted a multi-center, case-cohort study to evaluate if high plasma concentrations of a common PBDE congener in the first trimester increases the risk of preterm birth and its subtypes. Methods Pregnant women were recruited at the onset of initiation of prenatal care at Kaiser-Permanente Southern California (KPSC)-West Los Angeles and KPSC-San Diego medical centers. Plasma samples from women whose pregnancies ended preterm and random subset of those delivering at term were assayed for PBDE-47 and thyroid-stimulating hormone (TSH) by immunoassay. Quartile cutoffs were calculated for the patients at term and used to determine if women with exposures in the 4th quartile are at increased risk for preterm birth using logistic regression. Results We found that high concentrations of PBDE-47 in the first trimester significantly increased the odds of both indicated (adjusted odds ratio, adjOR=2.35, 95% confidence interval [CI]: 1.31, 4.21) and spontaneous (adjOR=1.76, 95% CI: 1.02, 3.03) preterm birth. Regardless of pregnancy outcome, TSH concentrations did not differ between women with high and low concentrations of PBDE-47. Conclusions These results suggest that high plasma concentrations of PBDE-47 in the first trimester, increases the risk of indicated and spontaneous preterm birth.

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259: Evaluation of a cumulative first trimester characteristic and serum marker risk score for predicting early spontaneous preterm birth

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2014.10.305 ◽

2015 ◽

Vol 212 (1) ◽

pp. S142

Author(s):

Laura L. Jelliffe-Pawlowski ◽

Rebecca Baer ◽

Yair Blumenfeld ◽

Christina Chambers ◽

Maurice Druzin ◽

...

Keyword(s):

Preterm Birth ◽

Risk Score ◽

First Trimester ◽

Serum Marker ◽

Spontaneous Preterm Birth

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508: Influence of earliest gestational age of prior spontaneous preterm birth on subsequent mid-trimester cervical length, pregnancy duration and cerclage efficacy

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2009.10.674 ◽

2009 ◽

Vol 201 (6) ◽

pp. S190 ◽

Cited By ~ 2

Author(s):

Deborah Wing ◽

Jeff Szychowski

Keyword(s):

Preterm Birth ◽

Gestational Age ◽

Cervical Length ◽

Spontaneous Preterm Birth

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Prediction of Spontaneous Preterm Birth in At-risk Women Using Thrombospondin 1 from Cervicovaginal Fluid: A Prospective Observational Study

Geburtshilfe und Frauenheilkunde ◽

10.1055/a-1486-7148 ◽

2021 ◽

Vol 81 (09) ◽

pp. 1055-1064

Author(s):

Johannes Stubert ◽

Kathleen Gründler ◽

Bernd Gerber ◽

Dagmar-Ulrike Richter ◽

Max Dieterich

Keyword(s):

At Risk ◽

Preterm Birth ◽

Predictive Value ◽

Transvaginal Ultrasound ◽

Area Under The Curve ◽

Cervical Length ◽

Multiple Gestation ◽

Spontaneous Preterm Birth ◽

Thrombospondin 1 ◽

Cervicovaginal Fluid

Abstract Introduction Thrombospondin 1, desmoplakin and stratifin are putative biomarkers for the prediction of preterm birth. This study aimed to validate the predictive capability of these biomarkers in patients at risk of preterm birth. Materials and Methods We included 109 women with symptoms of threatened spontaneous preterm birth between weeks 20 0/7 and 31 6/7 of gestation. Inclusion criteria were uterine contractions, cervical length of less than 25 mm, or a personal history of spontaneous preterm birth. Multiple gestations were also included. Samples of cervicovaginal fluid were taken before performing a digital examination and transvaginal ultrasound. Levels of cervicovaginal thrombospondin 1, desmoplakin and stratifin were quantified by enzyme-linked immunosorbent assays. The primary endpoint was spontaneous preterm birth before 34 + 0 weeks of gestation. Results Sixteen women (14.7%) delivered before 34 + 0 weeks. Median levels of thrombospondin 1 were higher in samples where birth occurred before 34 weeks vs. ≥ 34 weeks of gestation (4904 vs. 469 pg/mL, p < 0.001). Receiver operator characteristics analysis resulted in an area under the curve of 0.86 (p < 0.0001). At an optimal cut-off value of 2163 pg/mL, sensitivity, specificity, positive predictive value and negative predictive value were 0.94, 0.77, 0.42 and 0.99, respectively, with an adjusted odds ratio of 32.9 (95% CI: 3.1 – 345, p = 0.004). Multiple gestation, cervical length, and preterm labor had no impact on the results. Survival analysis revealed a predictive period of more than eight weeks. Levels of desmoplakin and stratifin did not differ between groups. Conclusion Thrombospondin 1 allowed long-term risk estimation of spontaneous preterm birth.

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