Effectiveness of Intravenous Ketorolac versus Intravenous Morphine Sulfate on Pain Control in Patients with Acute Renal Colic: A Phase 3 Randomized Clinical Trial

2017 ◽  
Vol 3 (3) ◽  
pp. 1-7
Author(s):  
Maryam Masaeli ◽  
Ahmadreza Khazaee ◽  
Masoud Shahabian
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Pain Control ◽  
Renal Colic ◽  
Morphine Sulfate ◽  
Phase 3 ◽  
Acute Renal Colic ◽  
Intravenous Morphine ◽  
Intravenous Ketorolac

scholarly journals Intranasal Ketamine Versus Intravenous Ketorolac for Pain Control in the Renal Colic: A Randomized Clinical Trial Study

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Khavanin ◽  
Meisam Moezzi ◽  
Hassan Motamed ◽  
Samaneh Parozan ◽  
Abdolreza Hosseini
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Pain Control ◽  
Renal Colic ◽  
Intervention Group ◽  
Vital Signs ◽  
Control Group ◽  
Post Dose ◽  
Patients Satisfaction ◽  
Intravenous Ketorolac

Background: Renal colic is one of the most common complaints among patients referring to the emergency department (ED). Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are gold standards to relieve pain. Objectives: The aim of this study was to evaluate the effects of intranasal Ketamine on pain control versus Ketorolac. Methods: In this randomized clinical trial (RCT), the patients were randomly assigned into two groups. While Ketorolac 30 mg was given intravenously to all patients in the control group, the patients in intervention group received 1 mg/kg drops of Ketamine intranasally. Pain severity, vital signs, and adverse events (AEs) were recorded after 60 min post-dose. Results: A total of 100 patients were enrolled in this study. The mean visual analog scale (VAS) score after the first 5 min was lower in the intranasal Ketamine group compared to control (5 ± 2.26 vs. 8.62 ± 0.49, respectively; P < 0.001), which remained significant at the end of 60th min (P < 0.001). Moreover, additional analgesics administration was higher in intravenous Ketorolac than intranasal Ketamine (22 vs 0%), which was significantly different (P = 0.001). Patients' satisfaction was higher in the intranasal Ketamine group compared to control (3.56 ± 0.35 vs. 1.82 ± 0.98, respectively; P < 0.001). Conclusions: Intranasal Ketamine was beneficial in controlling renal colic-induced pain, which could be prescribed as a treatment instead of normal treatment. It can rapidly improve pain relief in the short term, has lower AEs, and increases the patients' satisfaction.

scholarly journals Intravenous acetaminophen versus morphine sulfate in pain management of acute renal colic: a randomized clinical trial

2017 ◽  
Vol 4 (1) ◽  
pp. 39-43
Author(s):  
Seyyed Hosein Montazer ◽  
Behzad Feizzadeh ◽  
Farzad Bozorgi ◽  
Seyed Mohammad Hosseininejad ◽  
Ayyoub Barzegarnezhad ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Pain Management ◽  
Randomized Clinical Trial ◽  
Renal Colic ◽  
Morphine Sulfate ◽  
Intravenous Acetaminophen ◽  
Acute Renal Colic

Comparing Intradermal Sterile Water with Intravenous Morphine in Reducing Pain in Patients with Renal Colic: A Double-Blind Randomized Clinical Trial

2020 ◽  
Vol 15 (1) ◽  
pp. 76-82
Author(s):  
Javad Mozafari ◽  
Mohammadreza Maleki Verki ◽  
Fatemeh Tirandaz ◽  
Reza Mahjouri
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Renal Colic ◽  
Therapeutic Effects ◽  
Sterile Water ◽  
Morphine Group ◽  
Double Blind ◽  
Water Group ◽  
Intravenous Morphine ◽  
Painful Area

Objective: The present study was conducted to investigate the effect of intradermal administration of sterile water compared to intravenous morphine on patients with renal colic. Methods: This double-blind, randomized clinical trial study was conducted in 2017 to compare the therapeutic effects of intradermal sterile water with those of intravenous morphine on patients with renal colic presenting to the emergency departments (ED) of Imam Khomeini and Golestan Hospitals in Ahvaz, Iran. The first group received 0.5 ml of intradermal sterile water, and the second group 0.1mg/kg of intravenous morphine plus 0.5 ml of intradermal sterile water in the most painful area or the center of the painful area in the flank. The pain severity was measured using a visual analogue scale (VAS), and the medication side-effects were recorded at the beginning of the study and minutes 15, 30,45 and 60. Result: A total of 94 patients were studied in two groups. The mean severity of pain was 2.97 ± 1.51 in the sterile water group and 2.34 ± 1.89 in the morphine group at minute 30 (P=0.042), 2.58 ± 1.43 in the sterile water group and 1 ± 1.23 in the morphine group at minute 45 (p<0.001), and 1.89 ± 1.7 in the sterile water group and 0.52 ± 0.79 in the morphine group at minute 60 (p<0.001). Conclusion: Morphine reduces pain faster and more effectively than intradermal sterile water; nevertheless, treatment with intradermal sterile water can be used as an appropriate surrogate or adjunct therapy for pain control, particularly in special patients or in case of medication scarcity.

Intravenous Acetaminophen Versus Intravenous Morphine Sulfate for Isolated Diaphyseal Long Bone Fractures: A Randomized Clinical Trial

2017 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Morteza Talebi Deloee ◽  
Bahram Zarmehri ◽  
Elham Pishbin ◽  
Mona Najaf Najafi ◽  
Maryam Salehi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Bone Fractures ◽  
Morphine Sulfate ◽  
Long Bone ◽  
Long Bone Fractures ◽  
Intravenous Acetaminophen ◽  
Intravenous Morphine
Sign in / Sign up

Export Citation Format

Share Document