scholarly journals The State of Chronic Kidney Disease, ESRD, and Morbidity and Mortality in the First Year of Dialysis

2009 ◽  
Vol 4 (Supplement 1) ◽  
pp. S5-S11 ◽  
Author(s):  
Allan J. Collins ◽  
Robert N. Foley ◽  
David T. Gilbertson ◽  
Shu-Chen Chen
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
The State ◽  
Morbidity And Mortality ◽  
First Year

scholarly journals Calcific Uremic Arteriolopathy: Pathophysiology, Reactive Oxygen Species and Therapeutic Approaches

2010 ◽  
Vol 3 (2) ◽  
pp. 109-121 ◽  
Author(s):  
Kurt M. Sowers ◽  
Melvin R. Hayden
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Chronic Kidney Disease ◽  
Smooth Muscle ◽  
Kidney Disease ◽  
Vascular Smooth Muscle ◽  
Reactive Oxygen ◽  
Morbidity And Mortality ◽  
Oxygen Species ◽  
Calcific Uremic Arteriolopathy

Calcific uremic arteriolopathy (CUA)/calciphylaxis is an important cause of morbidity and mortality in patients with chronic kidney disease requiring renal replacement. Once thought to be rare, it is being increasingly recognized and reported on a global scale. The uremic milieu predisposes to multiple metabolic toxicities including increased levels of reactive oxygen species and inflammation. Increased oxidative stress and inflammation promote this arteriolopathy by adversely affecting endothelial function resulting in a prothrombotic milieu and significant remodeling effects on vascular smooth muscle cells. These arteriolar pathological effects include intimal hyperplasia, inflammation, endovascular fibrosis and vascular smooth muscle cell apoptosis and differentiation into bone forming osteoblast-like cells resulting in medial calcification. Systemic factors promoting this vascular condition include elevated calcium, parathyroid hormone and hyperphosphatemia with consequent increases in the calcium × phosphate product. The uremic milieu contributes to a marked increased in upstream reactive oxygen species—oxidative stress and subsequent downstream increased inflammation, in part, via activation of the nuclear transcription factor NFκB and associated downstream cytokine pathways. Consitutive anti-calcification proteins such as Fetuin-A and matrix GLA proteins and their signaling pathways may be decreased, which further contributes to medial vascular calcification. The resulting clinical entity is painful, debilitating and contributes to the excess morbidity and mortality associated with chronic kidney disease and end stage renal disease. These same histopathologic conditions also occur in patients without uremia and therefore, the term calcific obliterative arteriolopathy could be utilized in these conditions.

Evaluation of Longitudinal Exposure to Tacrolimus as a Risk Factor of Chronic Kidney Disease Occurrence Within the First Year Post-Liver Transplantation

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Pauline Maurel ◽  
Aurélie Prémaud ◽  
Paul Carrier ◽  
Marie Essig ◽  
Louise Barbier ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Liver Transplantation ◽  
Risk Factor ◽  
Kidney Disease ◽  
First Year ◽  
Disease Occurrence

scholarly journals Chronic kidney disease in Nigeria: an evaluation of the spatial accessibility to healthcare for diagnosed cases in Edo State

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Osaretin Oviasu ◽  
Janette E. Rigby ◽  
Dimitris Ballas
Keyword(s):  
Chronic Kidney Disease ◽  
Information System ◽  
Kidney Disease ◽  
Travel Time ◽  
The State ◽  
Spatial Accessibility ◽  
Geographical Information ◽  
Analysis Techniques ◽  
Edo State ◽  
Last Stage

Chronic kidney disease (CKD) is a growing problem in Nigeria, presenting challenges to the nation’s health and economy. This study evaluates the accessibility to healthcare in Edo State of CKD patients diagnosed between 2006 and 2009. Using cost analysis techniques within a geographical information system, an estimated travel time to the hospital was used to examine the spatial accessibility of diagnosed patients to available CKD healthcare in the state. The results from the study indicated that although there was an annual rise in the number of diagnosed cases, there were no significant changes in the proportion of patients that were diagnosed at the last stage of CKD. However, there were indications that the travel time to the hospital for CKD treatment might be a contributing factor to the number of diagnosed CKD cases. This implies that the current structure for CKD management within the state might not be adequate.

scholarly journals Stability of Target Hemoglobin Levels during the First Year of Epoetin Treatment in Patients with Chronic Kidney Disease

2007 ◽  
Vol 2 (5) ◽  
pp. 938-946 ◽  
Author(s):  
Luca De Nicola ◽  
Giuseppe Conte ◽  
Paolo Chiodini ◽  
Bruno Cianciaruso ◽  
Andrea Pota ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
First Year

Renal bone disease: a dietitian's perspective

2020 ◽  
Vol 5 (1) ◽  
pp. 18-25
Author(s):  
Ruth Kander
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arterial Stiffness ◽  
Dietary Restriction ◽  
Bone Disease ◽  
Morbidity And Mortality ◽  
Phosphate Binders ◽  
Renal Bone Disease ◽  
High Phosphate

Renal bone disease increases morbidity and mortality in patients with chronic kidney disease by increasing the risk for fractures, osteoporosis and other bone problems and its association with cardiovascular disease, including calcification and arterial stiffness. Treatment of renal bone disease is through a combination of three main methods to reduce phosphate levels: dietary restriction of high-phosphate foods; dialysis clearance; and the use of phosphate binders to prevent its absorption.

Phosphorus as an early marker of morbidity and mortality in type 2 chronic kidney disease diabetic patients

2013 ◽  
Vol 27 (4) ◽  
pp. 328-332 ◽  
Author(s):  
Ana Paula Silva ◽  
André Fragoso ◽  
Ana Pinho ◽  
Nelson Tavares ◽  
Ana Camacho ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Morbidity And Mortality ◽  
Diabetic Patients ◽  
Early Marker

scholarly journals NILAI TROMBOSIT PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS DI UNIT HEMODIALISIS BAGIAN/SMF ILMU PENYAKIT DALAM FK UNSRAT BLU RSUP PROF. DR. R. D. KANDOU MANADO

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Jesinta Kaparang ◽  
Emma Sy Moeis ◽  
Linda Rotty
Keyword(s):  
Internal Medicine ◽  
Chronic Kidney Disease ◽  
Side Effects ◽  
Kidney Disease ◽  
Blood Clotting ◽  
Secondary Data ◽  
The State ◽  
Heparin Induced Thrombocytopenia ◽  
At Iii

Abstract : Bacground: Stadium V Chronic Kidney Disease is less than 15 ml/mnt GFR, there is an accumulation of toxin uremia in blood that could harm the survival of patient, it is required a substitute therapy for the kidney,which is called hemodialysis. Hemodialisis needs anticoagulation, so blood clotting in circuit extracorporeal does not occur. In its development, have been tried several kinds of anticoagulation technique and anticoagulant which is made based on the state of the patient such as heparin, but in its using it can cause side effects. The work of heparin as anticoagulant dependents on anti thrombin (AT-III) that is an inhibitor of various factor of clotting. Heparin can cause changing of homeostasis because of its effect to the function of thrombosis ( thrombosis aggregation ) even to reduce the number of thrombosis ( Heparin Induced Thrombocytopenia ) . Purpose: To know and to study about the value of thrombosis in CKD patient who endure hemodialysis in unit hemodialisis Department of Internal Medicine BLU RSUP Prof. Dr.R.D. Kandou Manado.Method : Descriptive retrospective, using secondary data medic record in unit hemodyalisis Department of Internal Medicine BLU RSUP Prof. DR .R. D. Kandou Manado. Result: The thrombocytopenia patient increased on HD > 96 X, most of them are men in range 51 – 60 years old. Conclusion: CKD patient who endure hemodyalisis generally have normal thrombosis value, number of thrombocytopenia case is 25,45 % and number of most occurrence is commonly to men Keywords: chronic kidney disease, hemodialysis, thrombocytopenia.   Abstrak: Latar Belakang: Penyakit ginjal kronik stadium V yaitu LFG kurang dari 15 ml/mnt terdapat akumulasi toksin uremia dalam darah yang dapat membahayakan kelangsungan hidup pasien, sehinga di perlukan terapi penganti ginjal, terapi pengganti ginjal tersebut berupa hemodialisis. Pada hemodialisis diperlukan antikoagulasi supaya tidak terjadi pembekuan darah didalam sirkuit ekstrakorporeal. Dalam perkembangannya telah dicoba beberapa macam teknik antikoagulasi dan antikoagulan yang dibuat berdasarkan keadaan pasien,seperti heparin tetapi dalam pengunaanya heparin dapat memberikan efek samping Kerja heparin sebagai antikoagulasi bergantung pada antitrombin (AT-III) yaitu suatu inhibitor dari berbagai faktor pembekuan. Heparin menyebabkan perubahan hemostasis karena efeknya terhadap fungsi trombosit (agregasi trombosit) bahkan menurunkan jumlah trombosit (Heparin Induced Thrombocytopenia). Tujuan:Mengetahui dan mempelajari nilai trombosit pada pasien PGK yang menjalani hemodialisis di unit hemodialisis bagian/SMF Ilmu Penyakit Dalam BLU RSUP. Prof.Dr.R.D.Kandou manado. Metode Penelitian: Deskriptif retospektif dengan mengunakan data sekunder rekam medik di unit Hemodialisis Bagian/SMF Ilmu Penyakit dalam BLU RSUP  Prof.DR. R. D. Kandou  Manado. Hasil: Pasien yang mengalami trombositopeni mengalami peningkatan pada Hemodialisis lebih dari 96 kali, terbanyak berjenis kelamin laki – laki pada kelompok umur 51 – 60 tahun. Simpulan: Pasien PGK yang menjalani hemodialisis pada umumnya mempunyai nilai trombosit normal, jumlah kasus trombositopeni 25,45%, dan angka kejadian terbanyak umumnya pada laki –laki. Kata Kunci: Penyakit ginjal kronik, hemodialisis, trombositopeni

scholarly journals S0235 Effect of Chronic Kidney Disease on Short-Term Morbidity and Mortality in Patients With Colon Ischemia

2020 ◽  
Vol 115 (1) ◽  
pp. S68-S68
Author(s):  
Riana B. Jumamil ◽  
Joann Kwah ◽  
Juan Lin ◽  
Olga Aroniadis ◽  
Paul Feuerstadt ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Morbidity And Mortality ◽  
Short Term ◽  
Colon Ischemia
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