scholarly journals ASSOCIATION BETWEEN SERUM URIC ACID AND METABOLIC SYNDROME

2018 ◽  
Vol 11 (10) ◽  
pp. 400 ◽  
Author(s):  
Thaslima Nandhini Js ◽  
Savitha Basker G ◽  
Vishnupriya V
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Venous Blood ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Serum Triglycerides ◽  
Significant Difference ◽  
Disease Condition ◽  
Student’S T ◽  
Student’S T Test

Objective: Metabolic syndrome is a cluster of disease condition characterized by truncal obesity, hypertriglyceridemia, elevated blood pressure, and insulin resistance. An excessive circulating uric acid (UA) level even within normal range is always comorbid with metabolic syndrome and its components. The aim of the current study was to investigate the association between metabolic syndrome and serum UA level.Methods: A total of 60 subjects were divided into two groups of healthy (30 individuals) and metabolic syndrome patients (30 individuals) from dental outpatient department of Saveetha Dental College and Hospitals. 5 ml of fasting venous blood was collected in the plain collection tubes and centrifuged, and then serum was separated. Then, the serum was used to analyze the fasting blood glucose, serum triglycerides (TGLs), and serum UA by GOD-POD, enzymatic colorimetric, and uricase method, respectively. A statistical analysis was performed using Student’s t-test. p<0.05 was considered to be statistically significant.Result: Mean body mass index (BMI), fasting blood sugar (FBS), TGL, and UA level of control group were 23.36±1.81, 84.45±13.1, 110.9±22.6, and 3.48±1.21 respectively. Mean BMI, FBS, TGL, and UA level of study group were 35.24±3.04, 122.85±23.3, 212.1±39.6 and 9.08±2.63 respectively. There is a significant difference between these two groups with p<0.0001.Conclusion: This study showed that those individuals with metabolic syndrome have higher UA level that indicates hyperuricemia which is a significant predictor of metabolic syndrome.

scholarly journals Cholesterol Transporters ABCA1 and ABCG1 Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Metabolic Syndrome

Cholesterol ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Zahra Tavoosi ◽  
Hemen Moradi-Sardareh ◽  
Massoud Saidijam ◽  
Reza Yadegarazari ◽  
Shiva Borzuei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Mononuclear Cells ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Regulation Mechanism ◽  
Healthy Individuals ◽  
Peripheral Blood Mononuclear ◽  
Significant Difference ◽  
Abca1 Expression

ABCA1 and ABCG1 genes encode the cholesterol transporter proteins that play a key role in cholesterol and phospholipids homeostasis. This study was aimed at evaluating and comparing ABCA1 and ABCG1 genes expression in metabolic syndrome patients and healthy individuals. This case-control study was performed on 36 patients with metabolic syndrome and the same number of healthy individuals in Hamadan (west of Iran) during 2013-2014. Total RNA was extracted from mononuclear cells and purified using RNeasy Mini Kit column. The expression of ABCA1 and ABCG1 genes was performed by qRT-PCR. Lipid profile and fasting blood glucose were measured using colorimetric procedures. ABCG1 expression in metabolic syndrome patients was significantly lower (about 75%) compared to that of control group, while for ABCA1 expression, there was no significant difference between the two studied groups. Comparison of other parameters such as HDL-C, FBS, BMI, waist circumference, and systolic and diastolic blood pressure between metabolic syndrome patients and healthy individuals showed significant differences (P<0.05). Decrease in ABCG1 expression in metabolic syndrome patients compared to healthy individuals suggests that hyperglycemia, related metabolites, and hyperlipidemia over the transporter capacity resulted in decreased expression of ABCG1. Absence of a significant change in ABCA1 gene expression between two groups can indicate a different regulation mechanism for ABCA1 expression.

scholarly journals Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Lijuan Huang ◽  
Lihong Wu ◽  
Qiaohua Qiao ◽  
Lizheng Fang
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Clinical Data ◽  
Uric Acid Level ◽  
Acid Level ◽  
Lipid Level ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Colon Polyps ◽  
Infection Status

Background. This study investigated the relationships among the characteristics of colon polyps and potential risk factors, including metabolic condition, CEA level, uric acid level, and Helicobacter pylori (Hp) infection status. Method. Clinical data from patients who received colonoscopy were collected and analyzed, including patients’ gender, age, polyp pathology, metabolic syndrome (MS) status, CEA level, uric acid level, and Hp infection status. Patients were divided into a polyp group and a control group based on whether they presented with colon polyps. Then, clinical data were compared between the two groups to identify any differences between the groups and their relationships to colon polyps. Result. Compared with the control group, the polyp group had significant differences in patient gender, body mass index (BMI), waistline, blood pressure, fasting blood glucose level, blood lipid level, and uric acid level (p<0.05), but there were no significant differences in LDL and CEA levels (p>0.05). Patients with MS or a uric acid level>340 mg/dl had a greater tendency to develop colon polyps but this was not statistically significant. Conclusion. The incidence of colon polyps may be associated with MS and uric acid levels, but further studies are warranted to confirm this conclusion.

scholarly journals Evaluating the Effect of Slow-Stroke Back Massage on the Anxiety of Candidates for Cataract Surgery

2019 ◽  
Vol 12 (2) ◽  
pp. 12-17
Author(s):  
Maryam Keramati, MD ◽  
Mohammad Sadegh Sargolzaei, MSc ◽  
Ali Moghadasi ◽  
Mohammad Hasan Basirinezhad, MSc ◽  
Reza Mohammadpourhodki
Keyword(s):  
Cataract Surgery ◽  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
Paired Samples ◽  
Significant Difference ◽  
Student’S T ◽  
Dependent Samples ◽  
Student’S T Test ◽  
Back Massage

Background: The patients under cataract sur-gery often experience anxiety not only during the surgery, but also prior to the surgery.Purpose: We sought to determine the effects of slow-stroke back massage on anxiety in patients undergoing cataract surgery. Setting: The study was conducted in the Amiral-momenin Hospital of Zabol city, south-east of Iran.Participants: A total of 60 candidates of cataract surgery participated in the study.Research Design: The participants were ran-domly allocated to either control or intervention groups. The intervention group received slow-stroke back massages, while patients in control group received routine interventions.Intervention: The slow-stroke back massage was performed on the patients assigned to the interven-tion group. The intervention was performed in the morning of the surgery day at 30 minutes before the surgery. The researcher performed each mas-sage session in a sitting position. The duration of each massage session was 15 minutes. Main Outcome Measures: Anxiety was assessed in the both groups in the morning of the surgery, before and immediately after the intervention. In-dependent samples Student’s t test, paired samples Student’s t test, and chi-squared test were used to analyze the data.Results: Anxiety was not significantly different between the two groups before and after the mas-sage (p = .816). On the other hand, paired samples Student’s t test showed a significant difference comparing the anxiety scores before (49.7±5.43) and after (45.16±3.89) the massage in the interven-tion group (p < .001). Conclusions: Based on our results, slow-stroke back massage, which is a low-cost and safe method, reduced anxiety in patients who were candidates for cataract surgery.

scholarly journals ASSESSMENT OF INFLAMMATORY STATUS IN METABOLIC SYNDROME

2018 ◽  
Vol 11 (7) ◽  
pp. 259
Author(s):  
Nivesh Krishna ◽  
Anitha Roy ◽  
Savitha G
Keyword(s):  
Metabolic Syndrome ◽  
Normal Control ◽  
Venous Blood ◽  
Surrogate Marker ◽  
Control Group ◽  
Sample Collection ◽  
Serum Triglycerides ◽  
Inflammatory Status ◽  
Group 2 ◽  
Index Level

Objective: The aim of the present study was to assess the level of inflammation in metabolic syndrome (MetS) individuals by estimating C-reactive protein (CRP) in the individuals.Methods: A total of 60 subjects were selected from those attending the outpatient department of a private hospital and divided into two groups (n=30): Group 1 - healthy individuals and Group 2 - individuals with MetS. Informed consent was obtained from the subjects before sample collection. 5 ml of fasting venous blood was collected and centrifuged at 3000 rpm to separate serum, and then, it was analyzed for fasting blood sugar (FBS) by glucose oxidase-peroxidase method, serum triglycerides (TGL) by colorimetric enzymatic method, and serum CRP by Turbilatex method using ERBA CHEM 5 plus analyzer.Results: Mean body mass index level in control and MetS group is 22.73±2.14 and 35.53±3.57, respectively. Mean FBS levels in the control group and MetS group are 85.6±11.59 and 115.67±24.52, respectively. Mean TGL levels in the normal control group and MetS group are 105.63±30.26 and 181.07±47.76, respectively. Mean CRP levels in the normal control and MetS group are 3.17±1.22 and 8.34±2.48, respectively.Conclusion: CRP level positively correlated with MetS. Evaluation of CRP can be used as a surrogate marker to assess the inflammatory status of MetS individuals.

scholarly journals Is There Really Relationship between Androgenetic Alopecia and Metabolic Syndrome?

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Seyran Ozbas Gok ◽  
Asli Akin Belli ◽  
Emine Dervis
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Androgenetic Alopecia ◽  
Control Group ◽  
Metabolic Disturbances ◽  
Anthropometric Measures ◽  
Significant Difference ◽  
Age Range

Background.There are several studies investigating the relationship between androgenetic alopecia (AGA) and metabolic syndrome (MS) with conflicting results.Objective.We sought to investigate whether there is a relationship between AGA and MS.Methods.A case-control study including 74 male patients with AGA and 42 male controls was conducted. Age, duration of AGA, AGA onset age, anthropometric measures, body mass index, lipid parameters, fasting blood glucose, blood pressure, and presence of MS were recorded.Results.Of the 74 male AGA patients (age range 20–50 years, mean 32.14), 24 were in stage 2, 26 were in stage 3, 17 were in stage 3V, 1 was in stage 5, and 6 were in stage 7. There was no significant difference in the rate of MS between AGA and control groups(P=0.135). Among the evaluated parameters, only systolic blood pressure in AGA group was significantly higher than control group.Conclusion.In contrast to the most of the previous studies, our study does not support the link between AGA and MS. To exclude confounding factors such as advanced age and therefore metabolic disturbances, further studies are needed with large group of AGA patients including different age groups and varying severity.

scholarly journals Metabolic profiles differences of overweight patients on olanzapine, clozapine and risperidone

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S247-S248
Author(s):  
Siew Fai Liew ◽  
Gupta Bhanu ◽  
Jimmy Lee ◽  
Kok Seng Chee ◽  
Li Qi Neo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Atypical Antipsychotics ◽  
Fasting Blood Glucose ◽  
Metabolic Profiles ◽  
Metabolic Abnormalities ◽  
Long Term Effects ◽  
Serum Triglycerides ◽  
Significant Difference ◽  
Clinically Significant ◽  
Definition Of

AimsWe set out to examine the differences in metabolic profiles of at risk (overweight) patients across commonly used atypical antipsychotics (Olanzapine, Risperidone, Clozapine). We hypothesized that Olanzapine and Clozapine group will have more metabolic abnormalities compared to Risperidone.BackgroundCardiovascular diseases remain the leading cause of morbidity and mortality among people with schizophrenia. Since the introduction of atypical antipsychotics, there is cumulative evidence of their association with metabolic abnormalities. Clozapine and Olanzapine are known to constitute the highest metabolic risks amongst atypical antipsychotics.MethodThis study is based on the data of 67 subjects recruited into a 12-week open-labelled trial looking at the effects of adjunctive Aripiprazole in atypical antipsychotics for weight reduction and improvement in metabolic profile. Metabolic profiles including weight, waist circumference, fasting blood glucose, HbA1c, serum total, HDL and LDL cholesterol levels and triglycerides were measured at baseline. The measurements were then compared across the different subgroups of atypical antipsychotics. The definition of metabolic syndrome proposed by the Third Report of the National Cholesterol Education Program Expert Panel (Adults Treatment Panel III) was used.ResultThe atypical antipsychotics were grouped into Olanzapine (n = 27), Risperidone (n = 24) and Clozapine (n = 16). More than 50% of clozapine-treated and Olanzapine-treated overweight patients were demonstrated to have metabolic syndrome at baseline. There was a statistically significant difference in serum triglycerides (p = 0.012), LDL (p = 0.046) and HbA1c (p = 0.045) across the three groups as demonstrated by one-way ANOVA. A Tukey post hoc test showed that both the Olanzapine (p = 0.032) and Risperidone (p = 0.013) groups demonstrated statistically significant lower serum triglycerides when compared to Clozapine. Interestingly, the mean serum HbA1c was significantly lower in Clozapine when compared to Olanzapine group (p = 0.045), perhaps reflecting the closer monitoring of fasting blood sugar in clozapine patients. When controlled for age and BMI, the significant differences in serum triglycerides remain between Clozapine and Risperidone groups [but not for serum HbA1c]. There were no statistically significant differences across the groups with respect to other metabolic parameters.ConclusionAt baseline, metabolic dysregulation was demonstrated in all subgroups of overweight patients. As hypothesized, patients on Olanzapine and Clozapine groups fared worse than Risperidone. Further studies examining long term effects of atypical antipsychotics in a larger sample of patients are warranted to confirm these findings. These findings have clinical significance in terms of choosing the first antipsychotic for drug naïve patients or where there is no clinically significant difference in efficacy.

scholarly journals Effects of green tea on glycemic status in female metabolic syndrome patients

2020 ◽  
Vol 15 (2) ◽  
pp. 85-90
Author(s):  
Sabira Tabassum ◽  
Qazi Shamima Akhter
Keyword(s):  
Metabolic Syndrome ◽  
Green Tea ◽  
T Test ◽  
Control Group ◽  
Study Group ◽  
Ethical Aspect ◽  
Glycemic Status ◽  
Medical College ◽  
Student’S T ◽  
Student’S T Test

Background: According to International Diabetic Federation, around 20-25% of world adult population have the clinical features of metabolic syndrome (MetS). Different organizations recommend to modify lifestyle and dietary habit as primary intervention. Green tea has several pharmacological effects on metabolic diseases including MetS. Objective: To evaluate the effects of green tea consumption on two glycemic variables in women with MetS. Method: This interventional study was conducted in the Department of Physiology, Dhaka Medical College from January 2016 to December 2016. After fulfilling the ethical aspect, a total number of 42 female patients with MetS aged 40 to 50 years were selected from the outpatient department of Endocrinology, Dhaka Medical College Hospital. Participants were randomly assigned in study group (n=22) and control group (n=20). Study group consumed green tea for 12 weeks and the control group did not consume green tea. In both groups fasting serum glucose (FSG) and glycosylated hemoglobin (HbA1c) were measured by glucose oxidase (GOD/ PAP) method and modified high performance liquid chromatography (HPLC) method respectively 2 times (before and after 12 weeks). Data were analyzed by paired Student’s ‘t’ test and unpaired Student’s ‘t’ test. Results: After 12 weeks of intervention, FSG & HbA1c significantly (p<0.001) decreased in the study group than those of their baseline value and these values were also significantly (p<0.05) lower in comparison to those of control group. Conclusions: Regular consumption of green tea may improve glycemic status in patients with metabolic syndrome. J Bangladesh Soc Physiol. 2020, December; 15(2): 85-90

Benefits of Early Prosthetic Management of Transtibial Amputees: A Prospective Clinical Study of a Prefabricated Prosthesis

2002 ◽  
Vol 23 (6) ◽  
pp. 509-514 ◽  
Author(s):  
Lew C. Schon ◽  
Kelly W. Short ◽  
Olga Soupiou ◽  
Kenneth Noll ◽  
John Rheinstein
Keyword(s):  
Clinical Study ◽  
Postoperative Complications ◽  
Patient Outcomes ◽  
Control Group ◽  
Prospective Clinical Study ◽  
Significant Difference ◽  
Historic Control ◽  
Student’S T ◽  
Transtibial Amputees ◽  
Student’S T Test

To evaluate the use of an immediate postoperative prosthesis (IPOP) for transtibial amputees, we compared patient outcomes from a prospective clinical study of 19 patients managed with an IPOP with those of a retrospective review of a matched historic control group of 23 patients managed with standard soft dressings. Data were analyzed with the Student's t-test, and significance was set at P=0.05. The IPOP patients had no surgical revisions, whereas the patients with standard soft dressings had 11. This was a significant difference. IPOP patients also had significantly fewer postoperative complications and shorter times to custom prosthesis than did controls.

scholarly journals Histogenous Hypoxia and Acid Retention in Schizophrenia: Changes in Venous Blood Gas Analysis and SOD in Acute and Stable Schizophrenia Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Xingbing Huang ◽  
Qiu-Ling Lu ◽  
Xiu-Mei Zhu ◽  
Yi-Bin Zeng ◽  
Yun Liu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Venous Blood ◽  
Fasting Blood Glucose ◽  
Downward Trend ◽  
Control Group ◽  
Healthy Controls ◽  
Blood Gas ◽  
Stable Period ◽  
Significant Difference ◽  
Venous Blood Gas

Background: Oxidative stress may play an important role in the pathogenesis of schizophrenia (SCH), and there is considerable indirect evidence that hypoxia is closely related to SCH, but direct evidence of hypoxia in SCH has never been found.Methods:In this study, superoxide dismutase (SOD), venous blood gas, and Positive and Negative Syndrome Scale (PANSS) were examined in 40 SCH patients and compared with those of 40 healthy controls. The patients were treated with combination of atypical antipsychotics and Ditan Huayu Lishen decoction (a Chinese medicine decoction) and examined in the acute and stable period, respectively. Comparisons of indicators between two groups were performed using an independent-samples t-test, comparison of indicators between the acute and stable periods in the SCH group was performed using paired-samples t-test. Pearson correlation and multiple linear regression analyses were performed to investigate the relationships between the effect indicators.Results: Higher venous pH, PvO2, and fasting blood glucose levels and lower SOD, lactic acid, and PvCO2 levels were found in SCH patients compared with the control group; SOD was negatively correlated with the general psychopathology subscale score (PANSS-G), and PvO2 levels were closely related to venous pH in SCH and related to PvCO2 in the control group. It was also found that SOD activity showed no significant difference in acute and stable period, whereas PvO2 showed a downward trend, and venous pH was decreased significantly after treatment. Both the venous pH and PvO2 were higher in patients with SCH than that in healthy controls.Conclusion: It suggests that histogenous hypoxia and acid retention exist in relation to SCH, and there is an improvement of acid retention and a downward trend in histogenous hypoxia after combination treatment. Venous pH, PvO2, and PvCO2 are trait variables, but not state variables of SCH. The theory of histogenous hypoxia and acid retention can well explain the decrease in pH value and the increase in lactic acid in brain tissue of patients with SCH. Histogenous hypoxia and acid retention closely related to glucose metabolism. So they may play an important role in pathophysiology for SCH.

scholarly journals Metabolic profiles differences of overweight patients on olanzapine, clozapine and risperidone

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S248-S248
Author(s):  
Siew Fai Liew ◽  
Gupta Bhanu ◽  
Charmaine Tang ◽  
Jimmy Lee ◽  
Kok Seng Chee ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Atypical Antipsychotics ◽  
Fasting Blood Glucose ◽  
Metabolic Profiles ◽  
Metabolic Abnormalities ◽  
Long Term Effects ◽  
Serum Triglycerides ◽  
Significant Difference ◽  
Clinically Significant ◽  
Definition Of

AimsWe set out to examine the differences in metabolic profiles of at risk (overweight) patients across commonly used atypical antipsychotics (Olanzapine, Risperidone, Clozapine). We hypothesized that Olanzapine and Clozapine group will have more metabolic abnormalities compared to Risperidone.BackgroundCardiovascular diseases remain the leading cause of morbidity and mortality among people with schizophrenia. Since the introduction of atypical antipsychotics, there is cumulative evidence of their association with metabolic abnormalities. Clozapine and Olanzapine are known to constitute the highest metabolic risks amongst atypical antipsychotics.MethodThis study is based on the data of 67 subjects recruited into a 12-week open-labelled trial looking at the effects of adjunctive Aripiprazole in atypical antipsychotics for weight reduction and improvement in metabolic profile. Metabolic profiles including weight, waist circumference, fasting blood glucose, HbA1c, serum total, HDL and LDL cholesterol levels and triglycerides were measured at baseline. The measurements were then compared across the different subgroups of atypical antipsychotics. The definition of metabolic syndrome proposed by the Third Report of the National Cholesterol Education Program Expert Panel (Adults Treatment Panel III) was used.ResultThe atypical antipsychotics were grouped into Olanzapine (n = 27), Risperidone (n = 24) and Clozapine (n = 16). More than 50% of clozapine-treated and Olanzapine-treated overweight patients were demonstrated to have metabolic syndrome at baseline. There was a statistically significant difference in serum triglycerides (p = 0.012), LDL (p = 0.046) and HbA1c (p = 0.045) across the three groups as demonstrated by one-way ANOVA. A Tukey post hoc test showed that both the Olanzapine (p = 0.032) and Risperidone (p = 0.013) groups demonstrated statistically significant lower serum triglycerides when compared to Clozapine. Interestingly, the mean serum HbA1c was significantly lower in Clozapine when compared to Olanzapine group (p = 0.045), perhaps reflecting the closer monitoring of fasting blood sugar in clozapine patients. When controlled for age and BMI, the significant differences in serum triglycerides remain between Clozapine and Risperidone groups [but not for serum HbA1c]. There were no statistically significant differences across the groups with respect to other metabolic parameters.ConclusionAt baseline, metabolic dysregulation was demonstrated in all subgroups of overweight patients. As hypothesized, patients on Olanzapine and Clozapine groups fared worse than Risperidone. Further studies examining long term effects of atypical antipsychotics in a larger sample of patients are warranted to confirm these findings. These findings have clinical significance in terms of choosing the first antipsychotic for drug naïve patients or where there is no clinically significant difference in efficacy.

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