scholarly journals PULMONARY TUBERCULOSIS - A PROSPECTIVE ANALYSIS OF HEMATOLOGICAL CHANGES

2018 ◽  
Vol 11 (4) ◽  
pp. 169
Author(s):  
Sonti Sulochana ◽  
Subhashini V ◽  
Chitra Srinivasan
Keyword(s):  
Pulmonary Tuberculosis ◽  
Communicable Disease ◽  
Public Health Problem ◽  
Prospective Analysis ◽  
Major Public Health Problem ◽  
Common Condition ◽  
Pulmonary Tb ◽  
Acid Fast Bacilli ◽  
Childhood Tb ◽  
Hematological Changes

 Objective: This study was a prospective analysis of hematological changes in pulmonary tuberculosis (TB). The objectives of this study are (1) to study the changes in different parameters of hemogram in association of sputum-positive pulmonary TB, (2) to evaluate the disease severity and patient infectivity, (3) to determine the most common type and severity of anemia in pulmonary TB patients, and (4) to count platelets in pulmonary TB patients. TB is an important communicable disease in the world and is a major public health problem in India. Hematogical abnormalities associated with TB have been completely investigated in the literature though it is a common condition in India.Methods: A total of 150 patients of acid-fast bacilli-positive cases were included, and disseminated TB, childhood TB, and patients receiving anti-TB drugs were excluded from this study.Results: Among the 150 patients, anemia was observed in 116 cases, normocytic normchromic and microcytic hypochromic picture, leukocytosis in 68 patients, thrombocytosis in 50 patients, thrombocytopenia in 5 patients, and ESR levels were elevated in more than 82% of patients.Conclusion: A complete hemogram has been demonstrated in patients with acid-fast bacilli-positive cases in the present study. Since there was a paucity of literature in the hematological changes associated with TB, this study aimed at reinforcing the fact that they can be valuable tools in monitoring pulmonary TB.

scholarly journals Overview Of The Psysical Environment And The Nutritional Status Of Patient with Pulmonary Tuberculosis In The Lung Polyclinic Ngudi Waluyo Wlingi General Hospital at Desember 2014

2015 ◽  
Vol 2 (3) ◽  
pp. 248-254
Author(s):  
Enik Sulistyowati
Keyword(s):  
Elementary Education ◽  
Pulmonary Tuberculosis ◽  
Nutritional Status ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Government Programs ◽  
Pulmonary Tb ◽  
Home Ventilation ◽  
Direct Observations ◽  
The Subject

Pulmonary Tuberculosis (TB) is an infectious disease that still become a problem in the world.In Indonesia, pulmonary TB become one of the major public health problem and has yet to be handleddespite tight TB control efforts through government programs. This study aimed to describe the physicalenvironment and the nutritional status of patients with pulmonary TB in the lungs RSU Poly NgudiWaluyo Wlingi. This was a descriptive study, the subject of the research was pulmonary TB patients inRSU Ngudi Waluyo Wlingi, Blitar. Data obtained by using questionnaires and direct observations onnutritional status. There were 40 subjects, 67.3% were male sex, 20%, of the respondents came fromGandusari region, 37.5% were aged between 36–45 years, 45% of respondents had elementary education,37.5% working 37.5% Farmers and private work. Physical environment or home environmentshowed results better home lighting 77.5%, 82.5% home ventilation was not good, the density of residents90% was not good and 90% good home floor. The state of nutritional status shows 60% BMI in thecategory thin. This study shows that patients with pulmonary TB in the lungs RSU Poly Ngudi WaluyoWlingi, have homes that did not meet health requirements, especially in home ventilation componentsand occupant density, but it also had an excellent nutritional status was not indicated by the majorityof BMI into the category of thin.

scholarly journals Hubungan Hasil Pemeriksaan Sputum Basil Tahan Asam dengan Gambaran Luas Lesi Radiologi Tuberkulosis Paru di Rumah Sakit Al Islam Bandung

2019 ◽  
Vol 1 (1) ◽  
pp. 87-91
Author(s):  
Nova Triandini ◽  
Dyana Eka Hadiati ◽  
Usep Abdullah Husin ◽  
Tjoekra Roekmantara ◽  
Sadeli Masria
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lung Disease ◽  
Public Health Problem ◽  
International Union ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Purposive Sampling ◽  
Acid Fast Bacilli ◽  
Short Course

Tuberkulosis (TB) sampai saat ini masih merupakan masalah kesehatan masyarakat di dunia, walaupun upaya pengendalian strategi directly observed treatment short course (DOTS) telah diterapkan di banyak negara. Masalah yang dihadapi di negara maju maupun negara berkembang adalah keterlambatan mendiagnosis TB paru. Keterlambatan dalam diagnosis dan pengobatan TB paru dapat berasal dari pasien atau dari sistem pelayanan kesehatan. Tujuan penelitian ini mengetahui hubungan hasil pemeriksaan sputum basil tahan asam (BTA) menurut International Union Against Tuberculosis and Lung Disease (IUATLD) dengan gambaran luas lesi radiologi pada pasien TB paru dewasa di Rumah Sakit Al Islam Bandung periode 2016–2017. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan crosssectional. Penelitian dilakukan pada bulan Maret–Juni tahun 2018 dan subjek penelitian ini data pasien tuberkulosis paru di RS Al Islam dengan minimal sampel sebanyak 76 orang yang dipilih secara purposive sampling dan memenuhi kriteria inklusi. Instrumen pengumpulan data berupa rekam medis. Hasil penelitian menunjukkan BTA negatif dengan lesi minimal 21 dari 34, BTA+1 dengan lesi minimal 18 dari 23, BTA +2 dengan lesi moderately advanced 14 dari 21, dan BTA +3 lesi far advanced 16 dari 23. Hasil analisis Fisher’s Exact didapatkan nilai p=0.00 dengan kekuatan korelasi (rho) 0,51. Simpulan, terdapat hubungan cukup erat antara hasil pemeriksaan sputum basil tahan asam dan gambaran luas lesi radiologi pasien tuberculosis paru di RS Al Islam Bandung periode 2016–2017.RELATIONSHIP BETWEEN SPUTUM EXAMINATION RESULTS OF ACID FAST BACILLI AND EXTENT OF RADIOLOGICAL LESIONS IN PULMONARY TUBERCULOSIS AT AL ISLAM HOSPITAL BANDUNGTuberculosis (TB) is still a public health problem in the world, although direct observed treatment short course (DOTS) strategy control has been implemented in many countries. The problem faced in both developed and developing countries is the delay in diagnosing pulmonary TB. The delay in the diagnosis and treatment of pulmonary TB can come from the patient or from the health care system. The purpose of this study was to know the relationship between sputum examination results of acid fast bacilli (AFB) according to International Union Against Tuberculosis and Lung Disease (IUATLD) and extent of radiological lesions in patients with adult pulmonary TB at Al Islam Hospital Bandung from 2016–2017. This research was an observational analytic research with cross sectional approach. The study was conducted in March–June of 2018 and the subjects of this study were pulmonary tuberculosis patients in Al Islam Hospital with a minimum of 76 samples selected by purposive sampling and meeting inclusion criteria. Instrument data collection in the form of medical record. The results showed AFB negative with minimal lesion 21 of 24,  AFB + 1 with minimal lesion 18 of 23, AFB +2 with moderately advanced lesions 14 of 21, and AFB +3 far advanced lesions 14 of 23. Fisher’s exact analysis results obtained p=0.00 with correlation power (rho) 0.51. In conclution that there is a sufficiently close relationship between the results of examination of acid fast bacilli sputum and an extend of radiological lung tuberculosis patients in RS Al Islam Bandung from 2016–2017.

scholarly journals Acid fast bacilli detected in the oral swab sample of a pulmonary tuberculosis patient

2018 ◽  
Vol 51 (2) ◽  
pp. 91
Author(s):  
Reiska Kumala Bakti ◽  
Ni Made Mertaniasih ◽  
Diah Savitri Ernawati ◽  
Bagus Soebadi ◽  
Priyo Hadi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Buccal Mucosa ◽  
Symptom Assessment ◽  
Tuberculosis Patient ◽  
Rapid Screening ◽  
Pulmonary Tb ◽  
Acid Fast Bacilli ◽  
Dental Practitioners ◽  
Treatment Procedures

Background: Tuberculosis (TB) is an infectious disease that persists as a health problem worldwide. Mycobacterium tuberculosis, as an etiological agent, is transmitted from infected to uninfected individuals via airborne droplet nuclei. Oral health care workers or dental practitioners may be at high risk of TB infection because of their close proximity to infected individuals during treatment procedures. Simple and rapid screening of mycobacterium tuberculosis in the oral cavity is necessary in order to prevent transmission of infection. Purpose: To investigate the presence of acid-fast bacilli in the buccal mucosa of pulmonary TB patients. Methods: Nineteen pulmonary TB patients of both sexes, ranging in age from 19 to 74 years old participated in this study. The diagnosis of tuberculosis was performed by clinical symptom assessment and supporting examination, including acid-fast bacilli on sputum examination. Two buccal mucosa swabs taken from pulmonary TB patients were collected for acid fast bacilli direct smear by Ziehl Neelsen staining. Results: With regard to mycobacterium tuberculosis, acid-fast bacilli presented in 10.5% of the oral buccal mucosa swabs of subjects, whereas in the sputum specimens, bacilli were found in 52.6% of subjects. Conclusion: Acid-fast bacilli can be found in the buccal epithelial mucosa of pulmonary tuberculosis patients, although its presence was very limited.

scholarly journals Adjunct therapy of Jivantyadi Ghrita with Anti Tubercular drugs in Rajyakshama (Pulmonary Tuberculosis) – A Case Report

2020 ◽  
Vol 8 (04) ◽  
Author(s):  
Nandkishor Bhaurao Kale
Keyword(s):  
Side Effects ◽  
Pulmonary Tuberculosis ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Adjunct Therapy ◽  
Significant Clinical Improvement ◽  
Wbc Count ◽  
Anti Tubercular Therapy ◽  
Present Case Study

Rajyakshma is oldest disease known to mankind as its first reference found in oldest literature Rugveda. It is called as King of Diseases, which indicates its severity. Tuberculosis remains major public health problem not only in India but also in world. According to WHO one third of global population is suffering from tuberculosis. Anti-tubercular therapy is long lasting and has many side effects, so it is necessary to develop adjunct therapy which will minimize the hazards and help patient to improve the immune status. Aims and objective – To evaluate the toxicity reduction and early restoration by adjunct therapy of Jivantyadi Ghrit.  Methodology - In the present case study DOTs therapy in the dose of 3 tablets once per day was given as an adjunct with Jivantyadi Ghrit 10 ml BD per day was administered for a period of 6 months in the diagnosed case of pulmonary tuberculosis. Assessment was recorded. Results – WBC count and ESR rate reduced to normal, Haemoglobin level increased, SGPT and Sr. Bilurubin level remains normal. Also significant resolution of lung Koch’s lesions was noted radiologically. Conclusion - Jivantyadi Ghrit as an adjunct therapy with DOTs reduces the side effects (especially hepatic) of DOTs therapy and also shows significant clinical improvement in sign and symptoms of PTB.

scholarly journals PENGARUH TERAPI ACTIVE CYCLE OF BREATHING TECHNIQUE (ACBT) TERHADAP FREKUENSI PERNAFASAN (RESPIRATORY RATE) PADA PENDERITA TUBERKULOSIS PARU DI RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN

2021 ◽  
Vol 4 (2) ◽  
pp. 499-506
Author(s):  
Eka Nugraha Varida Naibaho ◽  
Sri Mega Herlina Kabeakan
Keyword(s):  
Pulmonary Tuberculosis ◽  
Quantitative Research ◽  
Public Health Problem ◽  
Respiratory Frequency ◽  
Wilcoxon Test ◽  
Major Public Health Problem ◽  
Breathing Patterns ◽  
Tuberculosis Patients ◽  
A Value ◽  
Post Test

Pulmonary tuberculosis is a major public health problem in the world and is the second leading cause of death from infectious diseases. The purpose of this study was to determine the effect of active cycle of breathing technique (ACBT) therapy on breathing frequency in patients with pulmonary tuberculosis. Quantitative research method, with a Quasi Experimental research design with a pre-test and one-group post-test approach. The study was carried out in the Orchid room of the Imelda Indonesian Workers General Hospital in Medan in July - August 2021. The study population was 45 patients with pulmonary tuberculosis and the sample technique of this study was Nonprobability Sampling. The number of samples was 41 pulmonary tuberculosis patients according to the researcher's criteria. The data analysis technique used is Wilcoxon test analysis. The results of the study There was an effect of breathing patterns before the administration of active cycle of breathing technique (ACBT) Therapy on the improvement of respiratory frequency in patients with pulmonary tuberculosis with a value of M ± SD = 17.1081 ± 2.94188. There is an effect of breathing pattern after administration of active cycle of breathing technique (ACBT) Therapy on the respiratory frequency of Pulmonary Tuberculosis Patients with a value of M ± SD = 27.0400 ± 2.82076. There is a difference in the effect of breathing patterns before and after administration of active cycle of breathing technique (ACBT) therapy on the Improvement of respiratory frequency in pulmonary tuberculosis patients with a significant value of 0.000 < 0.005.   Abstrak Tuberkulosis paru adalah masalah pokok kesehatan pada masyarakat didunia dan merupakan penyebab kematian ke dua dari penyakit infeksi. Tujuan penelitian untuk mengetahui pengaruh pemberian terapi active cycle of breathing technique (ACBT) terhadap frekuensi pernafasan pada penderita tuberkulosis paru. Metode penelitian kuantitatif, dengan desain penelitian Quasi Eksperiment dengan pendekatan pre test dan post test one group. Penelitian dilaksanakan di ruangan Anggrek Rumah Sakit Umum Imelda Pekerja Indonesia Medan pada bulan Juli - Agustus 2021. Populasi penelitian sebanyak 45 orang pasien Tuberkulosis Paru dan teknik sampel penelitin ini adalah Nonprobability Sampling. Jumlah sampel 41 orang pasien tuberkulosis paru sesuai dengan kriteria peneliti. Teknik analisa data yang digunakan adalah analisis uji Wilcoxon. Hasil penelitian ada pengaruh pola nafas sebelum pemberian terapi active cycle of breathing technique (ACBT) terhadap perbaikan frekuensi pernafasan pada penderita tuberkulosis paru dengan nilai M ± SD =17.1081 ± 2.94188. Ada pengaruh pola nafas sesudah pemberian terapi active cycle of breathing technique (ACBT) terhadap frekuensi pernafasan pasien tuberkulosis paru dengan nilai M ± SD = 27.0400 ± 2.82076. Ada perbedaan pengaruh pola nafas sebelum dan sesudah pemberian terapi active cycle of breathing technique (ACBT) terhadap perbaikan frekuensi pernafasan pasien tuberkulosis paru dengan nilai signifikan 0,000 < 0,005.

scholarly journals COMPARATIVE ASSESSMENT OF BIOCHEMICAL AND IMMUNOLOGICAL MARKERS IN TUBERCULOSIS

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Abhijit Ninghot ◽  
Kanchan Mohod ◽  
Mohd. Sameer Khan ◽  
Azmat Kamal Ansari ◽  
Satish Kumar
Keyword(s):  
Pulmonary Tuberculosis ◽  
Adenosine Deaminase ◽  
Sensitivity And Specificity ◽  
Sputum Sample ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Immunological Markers ◽  
Tuberculosis Antigen ◽  
Commercial Kits ◽  
Antigen Antibody

Introduction: Pulmonary tuberculosis is major public health problem in developing countries like India.Millions of people have died from tuberculosis. Many times it is difficult to get sputum sample from the patients. Some tests lack specificity, some other lack sensitivity. Hence, there is need of precise and faster diagnosis for patients attending hospitals. In this study, we compared the detection potential of biochemical and immunological markers(ADA, LDH and Mycobacterium tuberculosis H37Ra ES-31 & EST-6 antigens & antibodies based ELISAs) in pulmonary tuberculosis. Methods: 50 pulmonary tuberculosis cases confirmed by sputum examinationfor acid fast bacilli (AFB) and 50 age and sex matched control subjects were included in this study.ADA & LDH were estimated by using commercial kits. Tubercular antigens and antibodies were detected by ELISA method. Results: SerumADA detected pulmonary tuberculosis with sensitivityand specificityof 94%. Sensitivity and specificity of serum LDH in detecting pulmonary tuberculosis was found to be 94% and 36% respectively.Serumtubercular antigens detected pulmonary tuberculosis with sensitivity and specificity of 88%. Sensitivity and specificity of serum tubercular antibodies in detecting pulmonary tuberculosis was found to be 80% and 90% respectively. Conclusion: Adenosine deaminase has better detection potential over other markers in pulmonary tuberculosis. Keywords: Adenosine deaminase, Lactate dehydrogenase, Tuberculosis antigen-antibody

scholarly journals Relationship Between Dietary Approach to Stop Hypertension (DASH) Knowledge and Hypertension

2021 ◽  
Vol 1 (1) ◽  
pp. 91-96
Author(s):  
Fajar Awalia Yulianto ◽  
Eka Nurhayati ◽  
Ahmadillah Firdaus ◽  
Y. Elfi
Keyword(s):  
Public Health ◽  
Health Center ◽  
Dietary Intervention ◽  
Lifestyle Modification ◽  
Communicable Disease ◽  
Public Health Problem ◽  
Primary Data ◽  
Major Public Health Problem ◽  
National Guidelines ◽  
Public Health Center

The prevalence of non-communicable hypertension in Indonesia in 2007, 2013, and 2018 tends to increase. This phenomenon is predicted to continue. Riskesdas shows that the prevalence of hypertension in 2018 shows the number in the population aged over 18 years based on national measurements of 34.11%. Based on the annual report of the Cinunuk Public Health Center, it shows that hypertension is the largest non-communicable disease pattern in the Cinunuk Public Health Center in 2020, reaching 2672 cases of disease from 12517 cases of other diseases with a percentage of 21.34%. Hypertension is still a major public health problem associated with considerable morbidity and mortality. Hypertension can be controlled consistently by modifying a healthy lifestyle. The DASH (Dietary Approach To Stop Hypertension) dietary intervention recommended in national guidelines can substantially lower blood pressure in both people with hypertension and those without hypertension. This study aims to determine the relationship between knowledge of DASH (Dietary Approach To Stop Hypertension) and hypertension in Cinunuk village in 2021. This study was conducted using a quantitative method with a cross-sectional approach using primary data obtained through google form distribution. The research subjects were the people of Cinunuk Village, Cimekar, a total of 103 respondents who met inclusion and exclusion criteria. The results of this study indicate that there is a relationship between Knowledge of DASH and Hypertension in Cinunuk Village (P 0.049), where the hypertension proportion was significantly smaller (2.6%) than the no-hypertension percentage (15.6%) in the group who familiar with DASH. Lifestyle modification, including DASH, play an important role in controlling hypertension.

Kebutuhan Psikososial Keluarga yang Mempunyai Anggota Keluarga MenderitaTB Paru

1970 ◽  
Vol 3 (1) ◽  
Author(s):  
Noor Indyah Rachmawati ◽  
Suryani S ◽  
Chandra Isabella
Keyword(s):  
Pulmonary Tuberculosis ◽  
Public Health Problem ◽  
Sampling Technique ◽  
Treatment Programs ◽  
Psychosocial Needs ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Healthy Environment ◽  
The World ◽  
Development Goals

TB paru masih menjadi masalah kesehatan di Indonesia dan dunia. Upaya pengendalian TB paru menjadi perhatian dunia dan menjadi salah satu indikator dalam pencapaian tujuan pembangunan global. Peran keluarga dalam pengobatan TB paru sangat besar yaitu sebagai PMO, pemberi dukungan psikis dan menciptakan lingkungan yang sehat untuk mencegah penularan. Keluarga yang mempunyai anggota keluarga menderita TB paru sering mendapat stigma negatif sehingga bisa menyebabkan kegagalan dalam merawat pasien. Penelitian ini dilakukan untuk mengetahui gambaran kebutuhan psikososial keluarga yang mempunyai anggota keluarga menderita TB Paru di RS X. Jenis penelitian deskriptif kuantitatif dengan total sampling keluarga pasien TB Paru yang sedang dirawat sebanyak 57 orang. Hasil penelitian menunjukkan bahwa seluruh responden membutuhkan kebutuhan psikososial yang meliputi kebutuhan interaksi sosial, emosi, pengetahuan dan spiritual. Kebutuhan psikososial yang paling banyak dibutuhkan adalah dalam hal pengetahuan. Hal ini menunjukkan bahwa pengetahuan sangat berpengaruh terhadap peran keluarga sebagai PMO dan dalam merawat anggota keluarganya yang menderita TB paru. Kebutuhan dengan nilai persentase tertinggi adalah dalam hal spiritual pada item adanya harapan untuk kesembuhan anggota keluarga yang menderita TB paru. Berdasarkan hasil penelitian ini, diharapkan RS X berupaya meningkatkan pemenuhan kebutuhan psikososial keluarga, dengan cara menambah frekuensi penyuluhan, mengembangkan metode pemberian informasi untuk menguatkan pengetahuan atas informasi yang diberikan, kemudahan konsultasi dengan teknik konseling dapat diberikan untuk meningkatkan pengetahuan dan partisipasi keluarga dalam program pengobatan. Kata kunci: Kebutuhan psikososial, keluarga, TB Paru. Family’s Psychosocial Needs of Pulmonary Tuberculosis Patients AbstractPulmonary TB is still a public health problem in Indonesia and the world. Efforts in controlling TB desease are becoming a focus of the world and become one of the indicators in achieving global development goals. A families roles in TB treatment is very important as Supervisors to take medicine, giving psychological support and create a healthy environment to prevent desease spread. A family that has a member with TB desease oftenly receaved negative stigma hance it could result in treatment failure. This study was conducted to describe family’s psychosocial needs among pulmonary tuberculosis patients at X Hospital. This study is descriptive quantitative, using total sampling technique with family respondents pulmonary TB patients are being cared for as many as 57 people. The results showed that all respondents required psychosocial needs include the need for social interaction, emotional, knowledge and spiritual. This shows that the knowledge is very influential toward a families roles as Supervisor to take medicine and in caring for family members who suffer from tuberculosis. Needs with the higest percentage in terms of spiritual item is hope to recover from TB. Based on these results, it is expected X Hospital seeks to improve the fulfillment of the families psychosocial needs by way of to increase the frequency of health information, developed a method of providing information to strengthen knowledge on the information provided, ease of consultation with counseling techniques can be given to increase family participation in treatment programs. Key words: Family, psychosocial needs, pulmonary TB.

Clinico - Radiological and pulmonary function profile of treated pulmonary Tuberculosis patients

2020 ◽  
Vol 6 (2) ◽  
pp. 17-22
Author(s):  
Vishal N Kushare ◽  
Suvarna A Wagh
Keyword(s):  
Pulmonary Tuberculosis ◽  
Socioeconomic Development ◽  
Communicable Disease ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Control Program ◽  
Care Hospital ◽  
Important Public Health Problem ◽  
Major Barrier ◽  
Tuberculosis Patients

Tuberculosis causes most number of deaths due to infections worldwide. Around 9.0 million new cases and 1.5 million deaths registered worldwide of which 360,000 were HIV positive. One fourth of the global TB encumbrance occurs in India, making it the most important public health problem facing this country. It is estimated that out of 9.0 million cases worldwide, 2.3 million cases were reported in India. TB control program of India is on track as far as reduction in the disease burden. There is 42% lessening in humanity since 1990 and 51% lessening in TB pervasiveness as associated to 1990. Further, TB pervasiveness has concentrated from 40 lakhs to 28 lakhs annually from 1990. A total of 9,28,190 smear positive TB cases were diagnosed and 14,10,880 were registered for treatment under RNTCP. It has become a major barrier to our socioeconomic development. Tuberculosis (TB) still remains as the most common communicable disease. It is estimated that 21% of the global TB burden occurs in India. Two in every five Indians are infected with tuberculosis and two persons die every minute because of tuberculosis in India. This study focuses to study the clinico-radiological profile of treated pulmonary tuberculosis patients and to evaluate the risk factors that can influence the treatment outcome in a tertiary care hospital and to evaluate the type of limitation in lung function by spirometry in treated pulmonary tuberculosis patients.

scholarly journals Evaluation of Risk Factors for Hepatotoxicity in Patients Receiving Antitubercular Four Drugs Regimen in Initial Two Months

2015 ◽  
Vol 14 (1) ◽  
pp. 15-18
Author(s):  
Saifun Nahar Faiz ◽  
Nasreen Chowdhury ◽  
Md Aminul Haque Khan ◽  
Rukhsana Parvin
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Alcohol Intake ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
High Alcohol ◽  
Drug Induced ◽  
Study Results ◽  
Pre Treatment ◽  
High Alcohol Intake

Background: Tuberculosis (TB) is a major public health problem in Bangladesh since long before. Standard first line drugs are isoniazid, rifampicin, pyrazinamide and ethambutol. Of these, isoniazid, rifampicin and pyrazinamide have been observed to have hepatotoxic potentials. Drug Induced Hepatotoxicity (DIH) is an important and commonly encountered adverse effect with anti-TB treatment. A higher risk of hepatotoxicity has been reported in Bangladeshi patients than in their western counterparts. The reasons for the higher rate of hepatotoxicity in Bangladeshi patients are unclear. Objectives: To know the possible risk factors for the development of drug induced hepatotoxicity and to see their association with hepatoxicity in patients receiving antitubercular treatment as per National Tuberculosis Control Programme. Materials and Methods: In this cross sectional prospective study, 100 freshly diagnosed pulmonary tuberculosis patients attending the Medicine Outpatient Department, admitted in Chittagong Medical College Hospital, DOTS center in the hospital were selected for the study. Results: In this study we found twenty percent patients (20%) developed Antituberculosis Treatment (ATT) induced hepatotoxicity and most of them were in the age group of 50–65 years. Among the patients who developed hepatotoxicity (DIH) 27% patients were in BMI 18.5 group. The patients presenting with radiologically severe Pulmonary Tuberculosis (PTB) developed higher hepatotoxicity than patients with milder disease. The patients with history of high alcohol intake and with pre-treatment hypoalbuminemia were also found to have higher drug induced hepatotoxicity as compared to non-alcoholics and normal serum albumin level respectively. This study showed the evidence of ATT induced liver damage in twenty percent (20%) patients. Among them 05% cases developed overt drug induced hepatotoxicity (DIH) and remaining 15% cases had asymptomatic elevation of serum ALT, AST and bilirubin levels. The remaining 80% cases did not show any significant change in their serum bilirubin and/or enzyme levels as compared to pre-treatment levels. Conclusion: Advanced age, high alcohol intake, radiologically severe disease before treatment and pretreatment hypoalbuminemia are predisposing factors for the development of ATT induced hepatotoxicity.DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22873 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 15-18

Sign in / Sign up

Export Citation Format

Share Document