GENETIC SUSCEPTIBILITY OF TRANSCRIPTION FACTOR 7-LIKE 2 GENE VARIANT AND RISK OF TYPE 2 DIABETES IN ASIAN INDIANS

Background: The variants of transcription factor 7-like 2 (TCF7L2) gene have been shown to be associated with type 2 diabetes mellitus (T2DM) and its related complications. Objectives: We aimed to explore the possible association of rs7903146 (C/T) variant in TCF7L2 with the risk of T2DM in the North Indian population. Methods: The present case–control study included a total of 638 human subjects (318 T2DM subjects and 320 healthy controls). Various anthropometric, biochemical, and genetic parameters were studies in all the subjects. Genotyping of TCF7L2 gene was carried out using allele-specific polymerase chain reaction method. Results: The results of this study indicate significantly higher values of body mass index, waist circumference, waist-to-hip ratio, and body fat (%) in T2DM subjects than controls (p≤0.001). Dyslipidemia represented by higher levels of triglycerides and reduced values of high-density lipoprotein was more predominant in diabetic subjects compared to healthy subjects. The frequency of risk genotype (TT) frequency was significantly higher in T2DM subjects (16.4%) compared to controls (11.6%). The “T” allele was more dominant in diabetic subjects than controls. Logistic regression analysis of the data revealed a significant association of TT genotype with 2-fold (odds ratio with 95% of confidence interval; 2.09 [1.29–3.42] p=0.003) and CT genotype with 1.7-fold (1.73 [1.23–2.44] p=0.002) increased risk of developing T2DM. Conclusions: The present study demonstrated a significant association of rs7903146 (C/T) variant in TCF7L2 with the augmented risk of T2DM in North Indian population.

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Cell free TCF7L2 gene alteration and their association with Type 2 diabetes mellitus in North Indian population

Meta Gene ◽

10.1016/j.mgene.2020.100727 ◽

2020 ◽

Vol 25 ◽

pp. 100727 ◽

Cited By ~ 3

Author(s):

Amit Kumar Verma ◽

Mirza Masroor Ali Beg ◽

Mohd Saleem ◽

Fayez Al Reshidi ◽

Hafiz Ahmad ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Indian Population ◽

North Indian Population ◽

Tcf7l2 Gene ◽

Gene Alteration

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Abstract #251: Prevalence of Vitamin D Deficiency in Type 2 Diabetes Patients in North Indian Population and its Correlation with Diabetic Complications and Comorbidities

Endocrine Practice ◽

10.1016/s1530-891x(20)44959-6 ◽

2016 ◽

Vol 22 ◽

pp. 56-57

Author(s):

Brij Makkar ◽

Namrata Harichandan ◽

Jugal Sharma ◽

Rajeev Chawla ◽

Shalini Jaggi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Diabetic Complications ◽

Indian Population ◽

North Indian Population ◽

Diabetes Patients

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Evaluation of Transcription Factor 7 like 2 polymorphisms and haplotypes in risk of Type 2 Diabetes

Revista Romana de Medicina de Laborator ◽

10.1515/rrlm-2016-0038 ◽

2016 ◽

Vol 24 (4) ◽

pp. 423-430 ◽

Cited By ~ 5

Author(s):

Ramin Saravani ◽

Zahra Irani ◽

Hamid Reza Galavi

Keyword(s):

Type 2 Diabetes ◽

Transcription Factor ◽

Haplotype Analysis ◽

Amplification Refractory Mutation System ◽

Chronic Disorder ◽

Increased Risk ◽

Significant Difference ◽

Mutation System ◽

Control Study

Abstract Type 2 diabetes (T2D) is a chronic disorder with different genetics and environmental factors. It is one of growing diseases in the world. Previous studies show association between Transcription Factor 7 Like2 (TCF7L2) and T2D. The current study set to evaluate the relation between TCF7L2 polymorphisms and T2D in Southeast Iran. The present case-control study was done on 250 T2D and 250 healthy controls (HCs). For genotyping polymorphisms TCF7L2 (rs11196205) and (rs4132670) Amplification-Refractory Mutation System-Polymers Chain Reaction (ARMS-PCR) was used. The results showed frequency rates of GC and CC genotypes increased in patients compared to controls (31% vs. 6% and 55% vs. 8%, respectively), showing a statistically significant difference (OR=2.67(1.37-5.21), P<0.05 and OR=3.31(1.92-5.71), P< 0.05, respectively). The C allele was associated with an increased risk of T2D, with the frequency of 28% and 11% in patients and controls, respectively (OR=3.11 (2.22-4.37), P< 0.05). Another Polymorphism of this gene TCF7L2 (rs4132670) was not associated with T2D. Furthermore, the haplotype analysis revealed that rs11196205C/rs4132670C and rs11196205C/rs4132670T are risk factors against T2D (OR=2.08 (1.49-2.86, P<0.05 and OR=1.72 (1.06-2.78) P<0.05, respectively). The findings demonstrated that TCF7L2 (rs11196205) genotypes GC, CC, and allele (C) confer risk for susceptibility to T2D.

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Plasma Trimethylamine N-Oxide and Risk of Cardiovascular Events in Patients With Type 2 Diabetes

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgaa188 ◽

2020 ◽

Vol 105 (7) ◽

pp. 2371-2380 ◽

Cited By ~ 1

Author(s):

Mikael Croyal ◽

Pierre-Jean Saulnier ◽

Audrey Aguesse ◽

Elise Gand ◽

Stéphanie Ragot ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Events ◽

Tumor Necrosis Factor Receptor ◽

Density Lipoprotein ◽

Major Adverse Cardiovascular Events ◽

Cox Models ◽

Increased Risk ◽

All Cause Mortality ◽

Design And Methods

Abstract Objective Even though trimethylamine N-oxide (TMAO) has been demonstrated to interfere with atherosclerosis and diabetes pathophysiology, the association between TMAO and major adverse cardiovascular events (MACE) has not been specifically established in type 2 diabetes (T2D). Research Design and Methods We examined the association of plasma TMAO concentrations with MACE and all-cause mortality in a single-center prospective cohort of consecutively recruited patients with T2D. Results The study population consisted in 1463 SURDIENE participants (58% men), aged 65 ± 10 years. TMAO concentrations were significantly associated with diabetes duration, renal function, high-density lipoprotein cholesterol, soluble tumor necrosis factor receptor 1 (sTNFR1) concentrations (R2 = 0.27) and were significantly higher in patients on metformin, even after adjustment for estimated glomerular filtration rate (eGFR): 6.7 (8.5) vs 8.5 (13.6) µmol/L, respectively (PeGFR-adjusted = 0.0207). During follow-up (median duration [interquartile range], 85 [75] months), 403 MACE and 538 deaths were registered. MACE-free survival and all-cause mortality were significantly associated with the quartile distribution of TMAO concentrations, patients with the highest TMAO levels displaying the greatest risk of outcomes (P < 0.0001). In multivariate Cox models, compared with patients from the first 3 quartiles, those from the fourth quartile of TMAO concentration had an independently increased risk for MACE: adjusted hazard ratio (adjHR) 1.32 (1.02-1.70); P = 0.0325. Similarly, TMAO was significantly associated with mortality in multivariate analysis: adjHR 1.75 (1.17-2.09); P = 0.0124, but not when sTNFR1 and angiopoietin like 2 were considered: adjHR 1.16 (0.95-1.42); P = 0.1514. Conclusions We revealed an association between higher TMAO concentrations and increased risk of MACE and all-cause mortality, thereby opening some avenues on the role of dysbiosis in cardiovascular risk, in T2D patients.

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