scholarly journals RELATIONSHIP BETWEEN PROTON-PUMP INHIBITOR USE AND LOWER BLOOD MAGNESIUM LEVELS

2018 ◽  
Vol 10 (1) ◽  
pp. 367
Author(s):  
Wenny Dwi Putri ◽  
Retnosari Andrajati ◽  
Sudibyo Supardi

Objective: The aim of this study was to determine whether and to what degree proton-pump inhibitor (PPI) use affects blood magnesium levels.Methods: We performed a cross-sectional comparative study with consecutive sampling technique from June to October 2016. This study comparedblood magnesium levels of patients using PPIs (lansoprazole and omeprazole) with those of patients not taking PPIs. The total sample was 184 patients.Data collected included questionnaires and medical records. Statistical analysis was performed with the unpaired t-test, Mann–Whitney U-test, andone-way analysis of variance.Results: The average magnesium level in patients using PPIs was 2.08±0.21 mg/dL, whereas the average magnesium level in patients not using PPIswas 2.27±0.38 mg/dL, a statistically significant difference (p<0.001). Magnesium levels were significantly lower in patients using PPIs for >1 yearand in patients using omeprazole (p<0.05).Conclusion: Blood magnesium levels of patients using PPIs were significantly lower than those who did not use PPIs. Decreased levels of magnesiumin patients using PPI are affected by PPI type and the duration of PPI use - >1 year. Thus, the long-term use of PPIs may lead to decreased levels ofmagnesium. Therefore, monitoring the levels of magnesium is important in patients using PPIs for a long term to avoid the risk of hypomagnesemia.

Author(s):  
Made Dewi Ayu Untari

The purposes of this study are to obtain emperical evidence about the influence of followers investor’s behaviour to the stock volatility and analyze the difference offollowers investor’s betweenindustry sectors producing raw materials,manufacture industry and service industry in the Indonesia Stock Exchange (BEI), during the market crash happened in Indonesia. The population number are 507 companies, while the total sample of 247 companies. Sampling technique used purposive sampling. The analysis technique used was a cross-sectional absolute Deviation (CSADand test One Way ANOVA with Post Hoc Test and Least Significant Difference (LSD. Data shows that the behavior of follower investors has positive effect on the volatility of the current stock market crash occurs. Meanwhile, there was no difference in behavior between the follower investor industrial sectors producing raw materials, the manufacturing sector and the service sector when  the market crash.


2020 ◽  
Vol 4 (1) ◽  
pp. 48-52
Author(s):  
Gunawan Efri Syaputra ◽  
Dovy Djanas

Background: Preeclampsia is a pregnancy-specific syndrome in the form of reduced organ perfusion due to vasospasm and endothelial activation that occurs after 20 weeks of gestational age. eclampsia is the occurrence of seizures in a woman with preeclampsia, Sodium (Na +) and Potassium (K +) play an important role in preeclampsia and eclampsia.Objective: To see the difference in mean sodium potassium ratio between pregnancy with severe preeclampsia and eclampsia.Methods: The study was analytic descriptive using a cross sectional study design by looking at the medical records of the subjects according to the time and place of the study. Samples are all medical records of pregnant women who suffer from pre-eclampsia and eclampsia in the obstetric and gynecology section of  RSUP DR.M.Djamil padang in the period of 15 January 2016 to 31 December 2017, the values of which are sodium, potassium levels and sodium and potassium ratios. Samples were taken from populations that met the inclusion criteria and did not have exclusion criteria. Sampling using a consecuvite sampling technique which was taken from the medical records of RSUP DR. M. Djamil Padang Statistical analysis to assess significance using the T-test.Results: In the Severe preeclampsia and Eclampsia groups it was found that multipara parity had the highest respondents. This is in accordance with the literature where the incidence of preeclampsia is more often found at near term gestational age.Conclusion: There is no significant difference in the average sodium potassium ratio between Severe preeclampsia and EclampsiaKeywords: Severe preeclampsia, eclampsia, sodium and potassium


PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252785
Author(s):  
Lorena Maria Lima de Araújo ◽  
Maria Vivyanne de Moura Lopes ◽  
Rafael Silva de Arruda ◽  
Rand Randall Martins ◽  
Antonio Gouveia Oliveira

Aim To characterize the usage profile and the factors associated with the prolonged use of proton pump inhibitor drugs in a community pharmacy. Methodology This is a cross-sectional, prospective and observational study involving interviews with 410 patients who acquired PPI for their own use from community pharmacies. To characterize the factors associated with the prolonged use of PPI, a multivariate logistic regression model was used. Results Pantoprazole (42.7%) and omeprazole (31%) were the most acquired PPIs, prescribed mainly by gastroenterologists (49.5%). They are used in the morning, especially for gastrointestinal symptoms, however, they had been consumed for more than 5 years in 30% of cases. The factors associated with prolonged use are old age (OR 1.03 CI95% 1.01–1.05), body mass index (OR 1.07 CI95% 1.01–1.12), use of non-steroidal anti-inflammatories (OR 3.18 CI95% 1.20–8.43) and selective serotonin reuptake inhibitors (OR 3.5 95% CI 1.39–8.88). Conclusion PPIs are adequate in terms of indication and form of use, however, prolonged use associated with old age, being overweight and use of anti-inflammatories and antidepressants is frequent.


Author(s):  
Khoiriya Ardiani ◽  
Eko Nursucahyo ◽  
Tjatur Prijambodo ◽  
Muhammad Anas

Introduction: Injectable contraception is the most widely used type of contraception by Indonesian mothers because of its effective way of working, practical use, and lower price. However, in the use of injectable contraception, there are side effects, one of which is weight gain. Objective: To find out the differences in weight gain for 1-month and 3-months of injecting contraceptive acceptors. Method: This was an analytical observational study with a cross-sectional design. This research was conducted at the Independent Practice Midwife of Sri Retnaningtyas, Tambaksari District, Surabaya. The total sample is 110 respondents with a consecutive sampling technique. Data collection using medical records and statistical tests using independent sample t-test. Results: Analyzing the weight gain in the contraceptive injection acceptor that is the average injection of 1-month experienced of 2.16 kilograms and injections of 3-months experienced of 2.95 kilograms. The results of the independent t-test with a significance value of 0.039 (p <0.05). Conclusion: There was a significant difference in weight gain between 1-month and 3-months injective contraception acceptors, with the highest increase occurred in 3-months, injective contraceptive acceptors.


2020 ◽  
Vol 66 (7) ◽  
pp. 913-917
Author(s):  
Abadia Gilda Buso Matoso ◽  
Fernanda Arantes Mendonça Toledo Almeida ◽  
Lígia Paiva ◽  
Patrícia Munhoz Margonari ◽  
Tainá Mendes Bertolin ◽  
...  

SUMMARY OBJECTIVES To evaluate the frequency of prescription of proton pump inhibitors (PPIs) and their indications in patients hospitalized at the Hospital de Clínicas of the Federal University of Uberlândia (HC-UFU). METHODS This is a quantitative cross-sectional observational study that analyzes data obtained from patient records on prescriptions of PPIs for patients hospitalized at the HC-UFU and from a questionnaire applied to assistant physicians on the indications of the drug in each case and evaluates the indication based on literature data. RESULTS On a pre-determined day, of a total of 462 inpatients, there was a prescription of PPI for 183 (39.3%), with a higher frequency (73.5%) in the Intensive Care Unit (ICU), followed by the infirmaries and the Emergency Room. The assistant physician was located in 116 cases, and the main motivation referred to prescription was prophylaxis of digestive hemorrhage (77%). However, after reviewing medical records, it was noticed that in 50.8% of the cases, the prescription was not supported by the literature. CONCLUSION The frequency of PPI prescriptions for inpatients in the HC-UFU is among the lowest described in the literature, but there are still unnecessary prescriptions. Instruction and awareness of the assisting team can minimize these numbers.


2019 ◽  
Vol 6 (3) ◽  
pp. 105-113 ◽  
Author(s):  
Ivanka Hendrix ◽  
Amy T. Page ◽  
Maarit J. Korhonen ◽  
J. Simon Bell ◽  
Edwin C. K. Tan ◽  
...  

2020 ◽  
Vol 9 (2) ◽  
pp. 593-598
Author(s):  
Vivi Silawati ◽  
Yuyum Yumaidah ◽  
Bunga Tiara Carolin

Preschoolers with a poor parenting style allow the possible child’s development problems to occur in the future. This study aimed at knowing the significant difference between parenting styles of parents and grandmothers’ parenting styles to preschoolers’ development at Kindergartens in Cukanggalih village. This study used a cross-sectional design. Purposive sampling technique was used with a total sample of 30 people. The instrument used in this study was a development pre-screening questionnaire (KPSP). The processing of statistical data analysis was done using an independent t-test. The finding showed that there was a significant difference between the parenting styles of parents and the grandmothers’ parenting styles against the child’s motor development. The parenting style of parents is more suitable for a child’s motor development than the grandmothers’ parenting style


2020 ◽  
Vol 23 (15) ◽  
Author(s):  
S. Saradha ◽  
R. Arunkumar ◽  
M. Chokkalingam ◽  
A. Ruckmani ◽  
S. Babukumar ◽  
...  

2019 ◽  
Vol 1 (2) ◽  
pp. 8-15
Author(s):  
Zaim Ashari

During menstruation blood vessels in the uterus are very easily infected because germs easily enter and cause diseases of the reproductive tract. Some of the most common disorders are vaginal discharge and pruritus vulvae (vaginal itching). However, this complaint can be prevented by maintaining the cleanliness of the female organs early on, namely with good menstrual personal hygiene. This study aims to describe the level of personal hygiene knowledge about menstruation. This research is a descriptive study with a cross-sectional approach, with a total sample of 90 people taken by total sampling technique. The results showed that the majority of respondents had enough personal hygiene behavior as many as 82 people (91.1%), while good menstrual personal hygiene behavior was 3 people (3.3%), and respondents who had behaviors classified as less than 5 people ( 5.6%). Based on complaints on reproductive organs, respondents who experienced vaginal discharge were 85 people (94.4%) and itching around the genitals was around 83 people (92.2%).


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