scholarly journals Red blood cell distribution width as a prognostic biomarker for viral infections: prospects and challenges

2021 ◽  
Author(s):  
Oloche Owoicho ◽  
Kesego Tapela ◽  
Charles O Olwal ◽  
Alexandra L Djomkam Zune ◽  
Nora N Nganyewo ◽  
...  
Keyword(s):  
Blood Cell ◽  
Risk Prediction ◽  
Red Blood Cell ◽  
Viral Infections ◽  
Prognostic Biomarker ◽  
Predictive Biomarker ◽  
Viral Diseases ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Viral diseases remain a significant global health threat, and therefore prioritization of limited healthcare resources is required to effectively manage dangerous viral disease outbreaks. In a pandemic of a newly emerged virus that is yet to be well understood, a noninvasive host-derived prognostic biomarker is invaluable for risk prediction. Red blood cell distribution width (RDW), an index of red blood cell size disorder (anisocytosis), is a potential predictive biomarker for severity of many diseases. In view of the need to prioritize resources during response to outbreaks, this review highlights the prospects and challenges of RDW as a prognostic biomarker for viral infections, with a focus on hepatitis and COVID-19, and provides an outlook to improve the prognostic performance of RDW for risk prediction in viral diseases.

scholarly journals Red blood cell distribution width as a prognostic factor in patients undergoing transcatheter aortic valve implantation

2019 ◽  
Vol 74 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Yishay Szekely ◽  
Ariel Finkelstein ◽  
Samuel Bazan ◽  
Amir Halkin ◽  
Maria Abbas Younis ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Aortic Valve ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation ◽  
Red Blood Cell Distribution

Red Blood Cell Distribution Width (RDW) Correlates to the Anatomical Location of Colorectal Cancer. Implications for Clinical Use

2021 ◽  
Author(s):  
Alessandro Fancellu ◽  
Angelo Zinellu ◽  
Arduino Aleksander Mangoni ◽  
Anastasia Popova ◽  
Francesca Galotti ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Anatomical Location ◽  
Clinical Use ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Red Blood Cell Distribution Width, Disease Severity, and Mortality in Hospitalized Patients with SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (2) ◽  
pp. 286
Author(s):  
Angelo Zinellu ◽  
Arduino A. Mangoni
Keyword(s):  
Systematic Review ◽  
Blood Cell ◽  
Disease Severity ◽  
Red Blood Cell ◽  
Effect Size ◽  
Meta Analysis ◽  
Severe Illness ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The identification of biomarkers predicting disease severity and outcomes is the focus of intense research in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Ideally, such biomarkers should be easily derivable from routine tests. We conducted a systematic review and meta-analysis of the predictive role of the red blood cell distribution width (RDW), a routine hematological test, in patients with SARS-CoV-2 infection. We searched the electronic databases PubMed, Web of Science and Scopus, from January 2020 to November 2020, for studies reporting data on the RDW and coronavirus disease 2019 (COVID-19) severity, defined as severe illness or admission to the intensive care unit (ICU), and mortality. Eleven studies in 4901 COVID-19 patients were selected for the meta-analysis. Pooled results showed that the RDW values were significantly higher in patients with severe disease and non-survivors (standard mean difference, SMD = 0.56, 95% CI 0.31 to 0.81, p < 0.001). Heterogeneity between studies was extreme (I2 = 80.6%; p < 0.001). In sensitivity analysis, the effect size was not modified when each study was in turn removed (effect size range, between 0.47 and 0.63). The Begg’s (p = 0.53) and Egger’s tests (p = 0.52) showed no evidence of publication bias. No significant correlations were observed between SMD and age, gender, whole blood count, end point, study geographic area, or design. Our meta-analysis showed that higher RDW values are significantly associated with COVID-19 severity and mortality. This routine parameter might assist with early risk stratification in patients with SARS-CoV-2 infection.

scholarly journals Red blood cell distribution width is associated with incidence of atrial fibrillation

2013 ◽  
Vol 275 (1) ◽  
pp. 84-92 ◽  
Author(s):  
S. Adamsson Eryd ◽  
Y. Borné ◽  
O. Melander ◽  
M. Persson ◽  
J. G. Smith ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution
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