Polymeric micelles as drug delivery systems in cancer: challenges and opportunities

Nanomedicine ◽  
2021 ◽  
Author(s):  
Swati Biswas
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Clinical Translation ◽  
Current Status ◽  
Chemotherapeutic Drugs ◽  
Challenges And Opportunities

Tweetable abstract Micelles are nanocarriers for hydrophobic chemotherapeutic drugs. This editorial discusses the current status of preclinical micellar research and sheds light on the possibility of their clinical translation.

Strategies to improve insulin delivery through oral route: A review

2021 ◽  
Vol 18 ◽  
Author(s):  
Rohini Bhattacharya ◽  
Asha P. Johnson ◽  
Shailesh T. ◽  
Mohamed Rahamathulla ◽  
Gangadharappa H. V.
Keyword(s):  
Diabetes Mellitus ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Insulin Delivery ◽  
Peptide Hormone ◽  
Diabetes Mellitus Type 1 ◽  
Delivery Systems ◽  
Oral Insulin ◽  
Subcutaneous Route

: Diabetes mellitus is found to be among the most suffered and lethal diseases for mankind. Diabetes mellitus type-1 is caused by the demolition of pancreatic islets responsible for the secretion of insulin. Insulin is the peptide hormone (anabolic] that regulates the metabolism of carbohydrates, fats, and proteins. Upon the breakdown of the natural process of metabolism, the condition leads to hyperglycemia (increased blood glucose levels]. Hyperglycemia demands outsourcing of insulin. The subcutaneous route was found to be the most stable route of insulin administration but faces patient compliance problems. Oral Insulin delivery systems are the patient-centered and innovative novel drug delivery system, eliminating the pain caused by the subcutaneous route of administration. Insulin comes in contact across various barriers in the gastrointestinal tract, which has been discussed in detail in this review. The review describes about the different bioengineered formulations, including microcarriers, nanocarriers, Self-Microemulsifying drug delivery systems (SMEDDs), Self-Nanoemulsifying drug delivery systems (SNEDDs), polymeric micelles, cochleates, etc. Surface modification of the carriers is also possible by developing ligand anchored bioconjugates. A study on evaluation has shown that the carrier systems facilitate drug encapsulation without tampering the properties of insulin. Carrier-mediated transport by the use of natural, semi-synthetic, and synthetic polymers have shown efficient results in drug delivery by protecting insulin from harmful environment. This makes the formulation readily acceptable for a variety of populations. The present review focuses on the properties, barriers present in the GI tract, overcome the barriers, strategies to formulate oral insulin formulation by enhancing the stability and bioavailability of insulin.

Nanomedicine Applications in Treatment of Primary Central Nervous System Lymphoma: Current State of the Art

2021 ◽  
Vol 17 (8) ◽  
pp. 1459-1485
Author(s):  
Mengyao Wang ◽  
Ying Qu ◽  
Danrong Hu ◽  
Ting Niu ◽  
Zhiyong Qian
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Drug Delivery Systems ◽  
Central Nervous System Lymphoma ◽  
Delivery Systems ◽  
Brain Diseases ◽  
Current Status ◽  
Great Promise ◽  
Antitumor Effects

Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive subtype of extra nodal non-Hodgkin lymphoma (NHL), which is confined in the central nervous system (CNS). Despite recent advancements in treatment options, the overall prognosis of PCNSL remains poor. Among many unfavorable factors affecting efficacy, inadequate drug delivery into the CNS is still the thorniest challenge. Blood-brain barrier (BBB) constitutes a significant impediment, restricting entry of most therapeutics to the brain. Nanotechnology has offered great promise for brain diseases, as various nano-based drug delivery systems (NDDSs) have been developed for delivery of theranostic agents in to the CNS. These drug delivery systems possess significant advantages, including good feasibility, reliable safety profile, excellent BBB penetration and potent antitumor effects. As for treatment of PCNSL, numerous well-developed BBB-crossing nano-based strategies can be applied with proper modifications and improvements. Some exquisitely designed NDDSs specific for PCNSL have shown great potential. In this review, we provide a summary on current status of diagnosis and treatment of PCNSL, followed by an overview of BBB-crossing strategies applied in management of PCNSL, both novel and wellestablished. Finally, challenges and future perspectives in this field are also discussed.

scholarly journals Colloidal Drug Delivery Systems – Recent Advances With Polymeric Micelles

2008 ◽  
Vol 62 (10) ◽  
pp. 832-840 ◽  
Author(s):  
Karine Mondon ◽  
Robert Gurny ◽  
Michael Möller
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Recent Advances

scholarly journals Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review

2016 ◽  
Vol 22 (19) ◽  
pp. 2796-2807 ◽  
Author(s):  
Rafeeq Tanbour ◽  
Ana M. Martins ◽  
William G. Pitt ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems

scholarly journals Current status of in vivo bioanalysis of nano drug delivery systems

2020 ◽  
Vol 10 (3) ◽  
pp. 221-232
Author(s):  
Tingting Wang ◽  
Di Zhang ◽  
Dong Sun ◽  
Jingkai Gu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Current Status ◽  
Nano Drug Delivery

scholarly journals Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 365 ◽  
Author(s):  
Heejun Park ◽  
Eun-Sol Ha ◽  
Min-Soo Kim
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Application ◽  
In Vitro Digestion ◽  
Delivery Systems ◽  
Water Soluble ◽  
Current Status ◽  
In Vitro Tests

Self-emulsifying drug delivery systems (SEDDSs) are a vital strategy to enhance the bioavailability (BA) of formulations of poorly water-soluble compounds. However, these formulations have certain limitations, including in vivo drug precipitation, poor in vitro in vivo correlation due to a lack of predictive in vitro tests, issues in handling of liquid formulation, and physico-chemical instability of drug and/or vehicle components. To overcome these limitations, which restrict the potential usage of such systems, the supersaturable SEDDSs (su-SEDDSs) have gained attention based on the fact that the inclusion of precipitation inhibitors (PIs) within SEDDSs helps maintain drug supersaturation after dispersion and digestion in the gastrointestinal tract. This improves the BA of drugs and reduces the variability of exposure. In addition, the formulation of solid su-SEDDSs has helped to overcome disadvantages of liquid or capsule dosage form. This review article discusses, in detail, the current status of su-SEDDSs that overcome the limitations of conventional SEDDSs. It discusses the definition and range of su-SEDDSs, the principle mechanisms underlying precipitation inhibition and enhanced in vivo absorption, drug application cases, biorelevance in vitro digestion models, and the development of liquid su-SEDDSs to solid dosage forms. This review also describes the effects of various physiological factors and the potential interactions between PIs and lipid, lipase or lipid digested products on the in vivo performance of su-SEDDSs. In particular, several considerations relating to the properties of PIs are discussed from various perspectives.

The potential application of novel drug delivery systems for phytopharmaceuticals and natural extracts – current status and future perspectives

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohamad Fawzi Mahomoodally ◽  
Nabeelah Sadeer ◽  
Mehtaab Edoo ◽  
Katharigatta N. Venugopala
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Current Status ◽  
Novel Technologies ◽  
Alternative Drug ◽  
Low Toxicity ◽  
Novel Drug ◽  
Herbal Formulations

: Phytocompounds isolated from plants are well appraised for their broad pharmacological propensities in several pathologies. One key benefit of phytoconstituents is their relatively low toxicity and adverse effects. Nonetheless, poor solubility, permeation, and poor specificity at the target site tend to hinder its therapeutic efficacy. Hence, novel technologies for drug delivery systems are being developed via the use of various nanoformulation strategies to overcome these challenges and give uniform medication focusing at the dynamic site in desired concentration and improved therapeutic efficacy. Such approaches comprise of novel drug delivery systems (NDDS). The utilisation of herbal formulations for NDDS is more beneficious and advantageous as opposed to others. The utilisation of ethosome, liposome, emulsion, phytosomes, microsphere, and strong lipid nanoparticles of herbal formulation have improved the remedial impacts of plant extricates. With the utilisation of all these, directed delivery of the formulation is accomplished, because of which the formulation exhibits impact on the site, and the bioavailability of the formulation is likewise expanded. With these novel medication conveyance frameworks, the actives and concentrates which are utilised as part of natural formulations exhibit sustained release of formulation, enhancement in stability, improved therapeutic efficacy, and protection from toxicity. The primary motivation behind creating alternative drug delivery technologies is to expand the effectiveness of drug conveyance and safety in the process of drug conveyance and give more comfort to the patient. In this review, the importance of various phytocompounds in the delivery of drugs are highlighted as well as their importance in reducing the risk or diseases.

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