scholarly journals Role of flexible elastic nails in diaphyseal fractures of long bones of lower extremities in children of 5-14 years of age

2017 ◽  
Vol 3 (4h) ◽  
pp. 540-543
Author(s):  
Nitin Patil ◽  
Ketan Gupta ◽  
Rupesh Gor ◽  
Rutvik Shah ◽  
Prashant Pandey ◽  
...  
Author(s):  
Shrinivas Kalliguddi ◽  
K N Arun ◽  
Anirudh Kulkarni ◽  
Chandrakanth V Rathod ◽  
Praveen Reddy

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Lei Qin ◽  
Xuekun Fu ◽  
Jing Ma ◽  
Manxia Lin ◽  
Peijun Zhang ◽  
...  

AbstractOsteocytes act as mechanosensors in bone; however, the underlying mechanism remains poorly understood. Here we report that deleting Kindlin-2 in osteocytes causes severe osteopenia and mechanical property defects in weight-bearing long bones, but not in non-weight-bearing calvariae. Kindlin-2 loss in osteocytes impairs skeletal responses to mechanical stimulation in long bones. Control and cKO mice display similar bone loss induced by unloading. However, unlike control mice, cKO mice fail to restore lost bone after reloading. Osteocyte Kindlin-2 deletion impairs focal adhesion (FA) formation, cytoskeleton organization and cell orientation in vitro and in bone. Fluid shear stress dose-dependently increases Kindlin-2 expression and decreases that of Sclerostin by downregulating Smad2/3 in osteocytes; this latter response is abolished by Kindlin-2 ablation. Kindlin-2-deficient osteocytes express abundant Sclerostin, contributing to bone loss in cKO mice. Collectively, we demonstrate an indispensable novel role of Kindlin-2 in maintaining skeletal responses to mechanical stimulation by inhibiting Sclerostin expression during osteocyte mechanotransduction.


1994 ◽  
Vol 37 (2) ◽  
pp. 230-236 ◽  
Author(s):  
Kazuhiko Yokoyama ◽  
Masateru Shindo ◽  
Moritoshi Itoman ◽  
Makoto Yamamoto

2015 ◽  
Vol 4 (74) ◽  
pp. 12841-12845
Author(s):  
Venkateswara Rao D ◽  
Chinta Shyam Kumar ◽  
Anvesh Sangepu
Keyword(s):  

2006 ◽  
Vol 59 (1-2) ◽  
pp. 11-14 ◽  
Author(s):  
Viktorija Vucaj-Cirilovic ◽  
Kosta Petrovic ◽  
Olivera Nikolic ◽  
Viktor Till ◽  
Dijana Niciforovic ◽  
...  

Introduction. The aim of this study was to investigate the role of duplex Doppler ultrasonography in diagnosis of deep venous thrombosis (DVT) of the lower extremities. Material and methods. During a 2-year period, 860 patients were examined by duplex Doppler sonography. Among these, 619(72%) were women and 241 (28%) men, with the age-range of 16-91; (mean 56,2) years. Siemens Versa Pro color doppler was used, with 7MHz transducers. Findings were categorized into four categories: 1. deep venous thrombosis (DVT); 2. pathology predominantly related to superficial veins without DVT; 3. pathology of superficial and deep veins; 4. normal findings. Results. 185 (21%) patients had DVT, 366 (42.5%) patients had pre?dominant pathology of superficial veins: postthrombotic syndrome, superficial thrombophlebitis and varicose veins. 128 (14.9%) patients had pathology of superficial and deep veins. Normal findings were found in 181 (21.1%) patients. Conclusions. Various vascular and nonvascular diseases may mimic deep venous thrombosis, and that is why US should be used whenever possible to avoid unnecessary anticoagulant therapy. .


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