scholarly journals Combo effect of hypomagnesemia and hypokalaemia inducing nephrogenic diabetes insipidus in a patient with type 1 diabetes mellitus

2021 ◽  
Author(s):  
Esmail Sangey ◽  
Kishan Chudasama ◽  
Ahmad Mwinyi
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetes Insipidus ◽  
Type 1 Diabetes Mellitus ◽  
Arginine Vasopressin ◽  
Nephrogenic Diabetes Insipidus ◽  
Water Channels ◽  
Aquaporin 2 ◽  
Collecting Ducts

NDI is rarely considered versus diabetes mellitus in the situation of polyuria. It is well known that hypokalaemia and hypercalcemia induce NDI through decreased activity of arginine vasopressin and downregulation of Aquaporin-2 water channels in the collecting ducts. However, not much is known whether hypomagnesemia can directly induce NDI.

scholarly journals Wolfram syndrome: a case report with severe polyuria and secondary urological abnormalities

2021 ◽  
Vol 8 (4) ◽  
pp. 759
Author(s):  
Niranjan kumbara Hunasagatta Omkarappa ◽  
Prashanth Siddaiah ◽  
Shalini Sankalapura Rangaswamy ◽  
Ramu Anjanaiah ◽  
Devika Chennakeshava ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Case Report ◽  
Diabetes Insipidus ◽  
Type 1 Diabetes Mellitus ◽  
Optic Atrophy ◽  
Sensorineural Deafness ◽  
Wolfram Syndrome ◽  
Dependent Diabetes Mellitus

Wolfram syndrome is the condition characterized by juvenile onset diabetes mellitus and optic atrophy, which is also known as DIDMOAD. Classical Wolfram syndrome is a rare autosomal recessive disorder caused by mutations in WFS1, a gene involved in endoplasmic reticulum and mitochondrial function. Patients present with type 1 diabetes mellitus followed by optic atrophy in the first decade, diabetes insipidus and sensorineural deafness in the second decade, dilated renal outflow tracts as early as in the third decade, and various neurological abnormalities in the early fourth decade. We describe a case report of 14-year-old male child diagnosed as wolfram syndrome with type 1 diabetes mellitus, diabetes insipidus, deafness, optic atrophy and severe urological abnormalities. Patients who present with early onset insulin-dependent diabetes mellitus and optic atrophy together should be evaluated with respect to Wolfram Syndrome. If a patient, who is a known case of diabetes mellitus, presents with persistent polyuria or neurogenic bladder despite good glycemic control, suspicion of wolfram syndrome and further evaluation regarding the same must be made. Recognizing and timely management of this condition will help to improve the quality of life in the patient.

Effects of Self-Reported Adherence and Feedback in Pediatrics With Type 1 Diabetes Mellitus

2013 ◽  
Author(s):  
Blake M. Lancaster ◽  
Ashley M. Lugo ◽  
Lynne Clure ◽  
Kate S. Holman ◽  
Ryan T. Thorson
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus
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