scholarly journals The association of vitamin D deficiency with iron deficiency anemia in Turkish children aged between 4 months to 5 years old

2021 ◽  
Author(s):  
Emine Çelik ◽  
Rukiye Saç ◽  
Nermin Dindar Badem ◽  
Yıldız Dallar Bilge ◽  
Bulent Alioglu
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Turkish Children ◽  
Group I ◽  
Vitamin D Levels ◽  
Group Ii ◽  
25 Oh Vitamin D

Objectives: Iron deficiency anemia (IDA) is most frequent in children under five years old. Many studies have shown a high prevalence of vitamin D deficiency (VDD) in similar age group. An association between IDA and VDD was reported. The objective of our study was to determine whether there is an association of VDD with IDA in Turkish children under 5 years old. Methods: Children, ages between four months-five years were included in a case–control study. Two groups were constituted: children with IDA (group I) and healthy control children without IDA (group II). Serum 25(OH) vitamin D levels lower than 20 ng/mL were considered as deficiency. Results: Mean age of group I (n=211, 24.8±17.5 months, 45% males) and group II (n=149, 26.4±17.7 months, 44% males) were comparable (p>0.05). Median vitamin D level in group I (22.5 ng/ml) was lower than group II (32.3 ng/mL) (p=0.001). The frequency of VDD was 38.5% in group I and 14.5% in group II (p<0.001). Sixteen children had subclinical rickets signs (All <36 months old); 14 of these were in group I (p=0.034). Conclusions: VDD is more frequent in small children with IDA than healthy controls. Most of the children presenting subclinical rickets signs had concurrent IDA. Physicians should note that VDD or even subclinical rickets may associate to IDA in children younger than 36 months old.

scholarly journals Determining the Predictive Power of Vitamin D Levels in Iron Deficiency Anemia

2019 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Sorush Niknamian
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Levels ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Roc Curve Analysis ◽  
Vitamin D Levels

Background:Iron deficiency anemia is one of the most common hypochromic microcytic anemias and nutritional disorders in today’s world. Vitamin D is an important steroid hormone for the metabolism of serum calcium and phosphorus and plays a major role in the function of various body systems. Evidence suggests that vitamin D deficiency is associated with iron deficiency anemia. We aimed to compare the serum level of vitamin D between children with iron deficiency anemia and healthy ones. Methods: This case-control study was conducted on 60 patients with iron deficiency anemia and 60 healthy ones who did not suffer from iron deficiency anemia. Patients participated in the study voluntarily. Vitamin D levels were measured using HPLC and ferritin by RIA method. To estimate the predictive value of vitamin D levels in iron deficiency anemia, ROC curve analysis was used.  Results: In this study, 120 children aged 6-144 months with mean age of 30.2±31.4 months were analyzed; 49.2% of them were boys and 50.8% were girls. Vitamin D levels varied from 4.8 to 63.2 ng/ml with a mean of 23.87±12.57 ng/ml in all patients (19.25±9.15 ng/ml in the case group and 28.48±13.84 ng/ml in the control group (P<0.001). In other words, patients with a vitamin D level <23.6 ng/ml should be investigated for iron deficiency anemia, and sufficient vitamin D had a protective effect on iron deficiency anemia and each unit increase in vitamin D decreased the chance of iron deficiency anemia by 7.8%. Conclusion: The prevalence of simultaneous iron deficiency anemia and vitamin D deficiency is very high in children and there is a significant relationship between serum levels of 25(OH)D and hemoglobin.

scholarly journals Vitamin D as an Adjuvant Therapy in Neonatal Hypoxia: Is it Beneficial?

2019 ◽  
Vol 19 (3) ◽  
pp. 341-348
Author(s):  
Adel A. Hagag ◽  
Mohamed S. El Frargy ◽  
Amal E. Abd El-Latif
Keyword(s):  
Vitamin D ◽  
Adjuvant Therapy ◽  
Magnesium Sulphate ◽  
Recombinant Erythropoietin ◽  
Lower Serum ◽  
Group I ◽  
Vitamin D Levels ◽  
Grade Ii ◽  
Group Ii ◽  
25 Oh Vitamin D

Background: Neonatal hypoxic ischemic encephalopathy (HIE) is a potentially devastating disorder associated with significant mortality and long-term morbidity. Objective: The aim of this study was to study the role of vitamin D as an adjuvant therapy for management of neonatal HIE. Patients and Methods: This study was carried out on 60 neonates with HIE grade II who were diagnosed according to modified Sarnat staging and were divided in to 2 groups: Group I: Included 30 neonates with Sarnat grade II HIE who received single daily oral dose of vitamin D3 (1000 IU) for 2 weeks in addition to daily subcutaneous (SC) human recombinant erythropoietin (2500 IU/kg) for 5 days and IM or IV magnesium sulphate 250 mg/kg within half an hour of birth, and subsequently 125 mg/kg at 24 and 48 hours of life. Group II: Included 30 neonates with HIE grade II who received erythropoietin and magnesium sulphate as group I but without vitamin D. Two blood samples were taken from all neonates included in both groups; the 1st at diagnosis and the 2nd after 2 weeks of therapy. This study included also 30 healthy neonates as a control group. All neonates included in this study were subjected to: complete clinical examination with assessment of Apgar score at 5 and 10 minutes, measurement of arterial blood gases and serum 25 (OH) vitamin D, calcium, phosphorus, S100-B and IL-17 levels. Results: Before therapy, there were no significant differences between group I and II in PH, PO2 and PCO2 (p= 0.294, 0.462, 0.758 respectively), but after 2 weeks of therapy, there were significantly higher PH levels in group I compared with group II (p <0.001) while there were no significant differences between group I and II regarding PO2 and PCO2. Before therapy, there were no significant differences in serum 25(OH) vitamin D levels between group I and II while there were significantly lower serum 25(OH) vitamin D levels in group I and II compared with controls (P1; comparison between group I and II = 0.742, P2; comparison between group I and controls = 0.001 and P3; comparison between group II and controls = 0. 001). There were no significant differences between group I and II and between group I and II and control as regard serum calcium (P1= 0.943, P2= 0.875 and P3= 0.764) and phosphorus (P1= 0.862, P2= 0.921, P3= 0.786). There were no significant differences between group I and II regarding serum IL-17 levels while there were significantly lower serum IL-17 levels in group I and II compared with controls (P1 = 0.457, P2 = 0.043 and P3 = 0.023). Before therapy, there were no significant differences in serum S100-B levels between group I and II while there were significantly higher serum S100-B levels in group I and II compared with control (P1 = 0.381, P2 = 0.001 and P3= 0.001) but after therapy, there were significantly higher S100-B levels in group II compared with group I and significantly higher S100-B levels in group I and II compared with control (P1= 0.001, P2= 0.043, P3 = 0.001). There were significant negative correlations in group I between serum S100-B and PH and between S100-B and serum vitamin D before and after therapy. Conclusion: Vitamin D was found to improve the cases of group I as demonstrated by the reduction of serum S100-B levels after vitamin D therapy. Recommendations: Extensive multicenter studies are required on a large number of patients with Sarnat grade II HIE with longer duration of follow up to give valid recommendations about the use of vitamin D as an adjuvant therapy in Sarnat grade II HIE.

Interleukin 37 Levels in Relation to Serum Vitamin D Levels Among Ain Shams University Medical Students

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Randa Reda Mabrouk ◽  
Afaf Abdelalim Mostafa ◽  
Dina Aly Mohamed Aly Ragab ◽  
Fouad Mohamed Fouad zaki
Keyword(s):  
Vitamin D ◽  
Medical Students ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Group I ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Group Ii

Abstract Background The extraskeletal role of vitamin D is being increasingly recognized. This has important clinical implications, as vitamin D deficiency has reached epidemic proportions worldwide. Vitamin D has proposed anti-inflammatory properties as recent data suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. Interleukin-37(IL-37) is an IL1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response .IL37 plays a role in protecting the body against endotoxin shock, ischemia reperfusion injury, autoimmune diseases, and cardiovascular diseases. In addition, IL-37 has a potential antitumor effect. IL-37 and its receptors may serve as novel targets for the study, diagnosis, and treatment of immune-related diseases and tumors. Aim of the Work The aim of this study is to determine the relation between the level of interleukin-37 and 25-hydroxy Vitamin D among Ain Shams University medical students. Subjects and Methods The study was conducted at Clinical Pathology Department, Ain Shams University Hospitals. Ninety individuals, from medical students of Ain Shams University who participated in the Nutritional Assessment of Ain Shams University Medical Students (NAMESASU) Project, were selected to be in the study. The study included 2 groups: Group I: included 45 subjects selected from the NAMES-ASU project with deficient vitamin D serum levels. Group II: included 45 subjects selected from the NAMES-ASU project with sufficient vitamin D serum levels. Results There was a highly significant difference between the two groups regarding vitamin D levels. Serum IL-37 levels were significantly higher in group I subjects compared to group II subjects. No significant difference was observed between group I and group II regarding BMI, BFM, PBF and hsCRP. No significant difference was observed between the two subgroups regarding IL-37 levels and hsCRP levels. A highly significant negative correlation was observed between vitamin D levels and IL-37. A significant negative correlation was observed between hsCRP and vitamin D levels. However, no correlation was observed between hsCRP and IL-37 levels. Conclusion Data from our study showed that present study denote that in case of vitamin D deficiency, irrespective of BMI, a subclinical state of inflammation may be present as reflected by the increased hsCRP levels and this state of inflammation might induce an increase in IL-37, an anti-inflammatory cytokine, in an attempt to reduce the inflammation.

Prevention and treatment of iron deficiency anemia in multiple pregnancy

2020 ◽  
pp. 51-56
Author(s):  
T.G. Romanenko ◽  
◽  
O.V. Morozova ◽  
O.M. Sulimenko ◽  
◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Multiple Pregnancy ◽  
Erythrocyte Membranes ◽  
Deficiency Anemia ◽  
Multiple Pregnancies ◽  
Group I ◽  
Group Ii

The objective: to reduce the frequency and severity of iron deficiency anemia (IDA) in multiple pregnancies by optimizing its prevention, treatment and proving the effectiveness and safety of the therapy. Materials and methods. 90 pregnant women were under observation. The control group (CG) consisted of 30 pregnant women with one fetus, group I – 30 women with multiple pregnancies who did not use the recommended therapy, group II – 30 women with multiple pregnancies, conducted according to our proposed method. The effectiveness of therapy was evaluated weekly by subjective evaluation of improvement and according to laboratory parameters of peripheral blood. General clinical methods included clinical, general blood analysis and determination of serum iron, quantitative determination of the concentration of sulfhydryl groups and lipoproteins in erythrocyte elements of peripheral blood, studied the surface architecture of erythrocyte membranes. Results. There was a significant reduction in the frequency and severity of IDA in pregnant women of group II in 1.6 times.Diagnosed with a significant increase in the number of discocytes (group I 67.340.81; group II 84.531.04; p<0.05), a decrease in the number of ellipses (group I 0.990.05; group II 0.600.05; p<0.05); flat disks (group I 0.870.07; group II 0.560.03; p<0.05); dome-shaped (I group 2.410.14; ІІ group 1.820,11; р<0.05) and spherical erythrocytes (І group 4.110.12; ІІ group 2.440, 13; p<0.05). Significant decrease in the number of transitional forms (group I 3.410.31%; group II 2.530.21; p<0.05); pre hemolytic (I group 2.410.14%; ІІ group 1.440.11%; р<0.05) and degenerative forms (І group 1.180.14%; ІІ group 0.520.03; p<0.05), as well as the ratio of the inner and outer diameters of erythrocytes (group I 66.710.91; group II 45.810.63; p<0.05). There was a significant increase in the ratio of sulfhydryl groups and lipoproteins in erythrocyte membranes. Conclusions. The complex composition of the drug Fersinol and Fersinol-Z, taking into account the effective antianemic action, can be considered optimal for the prevention and treatment of iron deficiency in multiple pregnancies and recommended for use in practical health care. Keywords: multiple pregnancy, iron deficiency anemia, prevention, treatment, Fersinol ampoules, Fersinol-Z capsules.

scholarly journals Role of vitamin A supplementation in management of iron deficiency anemia in children

2018 ◽  
Vol 5 (4) ◽  
pp. 1477
Author(s):  
Arnab Biswas
Keyword(s):  
Iron Deficiency ◽  
Vitamin A ◽  
Iron Deficiency Anemia ◽  
Standard Dose ◽  
Ferrous Sulphate ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Chi Square ◽  
Group I ◽  
Group Ii

Background: The objective of the study were to study the effect of the supplementation of vitamin A along with standard dose of iron on hematopoiesis in children with documented iron deficiency anemia, a hospital based prospective study is carried out for 6 months on children with documented iron deficiency anemia in OPD and indoor patients of the department of paediatric medicine, Medical College Kolkata..Methods: Thirty children (1-12 years age) presenting with iron deficiency anemia (hemoglobin less than 10 g/dl, mean corpuscular volume (MCV) <75 fl, and serum iron <55 mcg/dl) were studied in two groups of 15 each. Group I was supplemented with iron (ferrous sulphate 3 mg/kg/d) while group II in addition to iron was also supplemented with vitamin A (5000 IU/d).Collected data were expressed as mean±SE. Comparison of variables was done by using student t test or chi square test as applicable. P<0.0001 was taken as statistically significant.Results: Hemoglobin concentration was found to be significantly increased after 4 weeks of iron supplementation. Rise in hemoglobin was comparatively more in group II, as compared to group I, after 4 and 8 weeks.Conclusions: The result of this study suggests that supplementation of vitamin A improves hematopoiesis.

Vitamin D deficiency and iron deficiency anemia in women in menopausal transition period. Clinical case

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 87-90
Author(s):  
Nina A. Tatarova ◽  
Margarita S. Airapetian
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Transition Period ◽  
Water Soluble ◽  
Menopausal Transition ◽  
Deficiency Anemia ◽  
Drug Of Choice ◽  
Increased Risk

Vitamin D is a regulator of immune response, and plays a role in the development of cardiovascular diseases, insulin resistance and diabetes mellitus, obesity, autoimmune disorders, iron binding, anemia, respiratory viral and other diseases. In addition, vitamin D deficiency contributes to the chronicity of infections and an increased risk for number of oncological pathology. The developing immunosuppression in women with iron deficiency anemia in the menopausal transition period does not allow to fully compensate for iron deficiency with monotherapy if vitamin D deficiency is present. The drug of choice in this situation is micellized (water-soluble) vitamin D3(Aquadetrim).

Prevalence of 25-Hydroxyvitamin D Deficiency in Korean Patients with Anemia

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 5164-5164
Author(s):  
Eun-Hyung Yoo ◽  
Hyun-Jung Cho
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Cellular Proliferation ◽  
World Health ◽  
Deficiency Anemia ◽  
Korean Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Abstract Abstract 5164 Background: Vitamin D deficiency is a very common health problem in Korea. Vitamin D has been suggested to have an important role on nonskeletal functions including cellular proliferation and differentiation, muscle function, immunity and erythropoiesis. Recent studies have been reported that vitamin D deficiency had associated with iron deficiency anemia, anemia of chronic kidney disease, and anemia of inflammation. In this study, we investigated the prevalence of vitamin D deficiency in Korean patients with anemia and also analyzed the association between vitamin D status and specific subtypes of anemia. Methods: A total of 147 anemic patients (median age 66 years, range 19∼91 years) and 300 nonanemic controls (median age 60 years, range 29∼87 years) were included. Anemia was defined according to World Health Organization (WHO) criteria. Serum 25- hydroxyvitamin D [25(OH)D] was measured using electrochemiluminescence immunoassay. The deficiency of 25(OH)D was defined as <20 ng/mL and severe deficiency was defined as <10 ng/mL. We compared serum 25(OH)D levels based on the presence and subtypes of anemia. Results: The prevalence of 25(OH)D deficiency was 74% (109/147) and 70% (210/300) in anemic (median Hb 9. 6 g/dL) and nonanemic group (median Hb 14. 3 g/dL), respectively. The prevalence of severe 25(OH)D deficiency was significantly higher in anemic group than in nonanemic group [44. 8% (66/147) vs 11. 7% (35/300), P<0. 0001] Odds ratio for severe 25(OH)D deficiency in anemic patients was 6. 17 (95% CI 3. 820–9. 965, P<0. 0001). The prevalence of 25(OH)D deficiency was not different between iron deficiency anemia (IDA) group and anemia of chronic disease (ACD) group. However, the serum 25(OH)D levels of ACD patients were lower than those of IDA patients in male (median 25(OH)D 14. 34 ng/mL vs 23. 04 ng/mL, P=0. 04). Conclusion: This study demonstrates that severe vitamin D deficiency is associated with anemia in Korea. Although vitamin D deficiency is also very common in nonanemic Korean population, anemia is related to much worse vitamin D deficient status. Multiple factors including poor nutritional status and potential roles of vitamin D on inflammation and erythropoiesis might be considered. Disclosures: No relevant conflicts of interest to declare.

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