scholarly journals The factors that affecting shockwave lithotripsy treatment outcome of kidney stones

Author(s):  
MEHMET VEHBİ KAYRA ◽  
Mehmet Resit GOREN ◽  
Cevahir Ozer ◽  
Ferhat Kilinc

Bacground: We aimed to analyze combination of the schockwave lithotripy (SWL) success predictors. Methods: In this retrospective study, the outcomes of the patients with kidney stones treated with SWL were analyzed. Adult patients (≥18 years) with complete records with non-contrast computed tomography (NCCT), stone analysis, laboratory data were involved in the study. Patients who were with urinary system anomalies, who were receiving alpha-blocker and/or calcium channel blockers and whom with impaired kidney function were excluded. The effect of stone density, skin-to-stone distance (SSD), perirenal tissue density (PTD), subcutaneous tissue density (STD), stone size, stone burden, stone localization, infundibulopelvic angle (IA), as well as body mass index (BMI) and stone analysis results on the success of the treatment was evaluated. Results: SSD, PTD, STD, stone localization, IA, as well as body-mass index, did not have any association with SWL success. Stone size and stone burden had a significant association with treatment success (p = 0.0001), and the cut-off values determined for stone size and stone burden were 12.95 mm (p = 0.0006) and 121.38 mm2 (p = 0.004) respectively. Stone density also had a significant association with treatment success (p = 0.0001), and the cut-off value determined for stone density was 739 HU (Hounsfield Unit) (p = 0.001). Treatment success was significantly lower in cystine and calcium oxalate monohydrate stones compared to other stone types (p = 0.019). Conclusion: Significant markers that determine SWL effectiveness are stone size, stone burden, stone density and, besides, stone type.

2011 ◽  
Vol 108 (7) ◽  
pp. 1192-1197 ◽  
Author(s):  
Gencay Hatiboglu ◽  
Valentin Popeneciu ◽  
Martin Kurosch ◽  
Johannes Huber ◽  
Sascha Pahernik ◽  
...  

1998 ◽  
Vol 9 (9) ◽  
pp. 1645-1652
Author(s):  
G C Curhan ◽  
W C Willett ◽  
E B Rimm ◽  
F E Speizer ◽  
M J Stampfer

A variety of factors influence the formation of calcium oxalate kidney stones, including gender, diet, and urinary excretion of calcium, oxalate, and uric acid. Several of these factors may be related to body size. Because men on average have a larger body size and a threefold higher lifetime risk of stone formation than women, body size may be an important risk factor for calcium oxalate stone formation. The association between body size (height, weight, and body mass index) and the risk of kidney stone formation was studied in two large cohorts: the Nurses' Health Study (NHS; n = 89,376 women) and the Health Professionals Follow-up Study (HPFS; n = 51,529 men). Information on body size, kidney stone formation, and other exposures of interest was obtained by mailed questionnaires. A total of 1078 incident cases of kidney stones in NHS during 14 yr of follow-up and a total of 956 cases in HPFS during 8 yr of follow-up were confirmed. In both cohorts, the prevalence of a stone disease history and the incidence of stone disease were directly associated with weight and body mass index. However, the magnitude of the associations was consistently greater among women. Specifically, the age-adjusted prevalence odds ratio for women with body mass index > or = 32 kg/m2 compared with 21 to 22.9 kg/m2 was 1.76 (95% confidence interval, 1.50 to 2.07), but 1.38 (95% confidence interval, 1.16 to 1.65) for the same comparison in men. For incident stone formation, the multivariate relative risks for the similar comparisons were 1.89 (1.51 to 2.36) for women and 1.19 (0.83 to 1.70) in men. Height was inversely associated with the prevalence of stone disease but was not associated with incident stone formation. These results suggest that body size is associated with the risk of stone formation and that the magnitude of risk varies by gender. Additional studies are necessary to determine whether a reduction in body weight decreases the risk of stone formation, particularly in women.


2007 ◽  
Vol 177 (4S) ◽  
pp. 420-420
Author(s):  
Igor Sergeyev ◽  
Philip T. Koi ◽  
Stacy L. Jacobs ◽  
Alia Godelman ◽  
David M. Hoenig

Cancer ◽  
2000 ◽  
Vol 89 (2) ◽  
pp. 369-375 ◽  
Author(s):  
Prudence B. Lam ◽  
Pamela M. Vacek ◽  
Berta M. Geller ◽  
Hyman B. Muss

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247945
Author(s):  
Zekariyas Sahile ◽  
Robel Tezera ◽  
Damen Haile Mariam ◽  
Jeffrey Collins ◽  
Jemal Haider Ali

Background Remaining underweight during Tuberculosis (TB) treatment is associated with a higher risk of unsuccessful TB treatment outcomes and relapse. Previous studies conducted in Ethiopia found that bodyweight not adjusted for height at the start of treatment is associated with poor treatment outcomes. However, the association of body mass index (BMI) and weight change during treatment with treatment outcomes has not been studied. We aimed to investigate the association of BMI at the time of diagnosis and after two months of treatment and TB treatment outcomes. Methods Using an ambi-directional cohort study design (retrospective and prospective), a total of 456 participants were enrolled among 30 randomly selected public health centers residing within six sub-cities of Addis Ababa, Ethiopia. Data were collected using medical chart abstraction and face to face interviews. We compared TB treatment outcomes in persons with a body mass index (BMI) <18.5kg/m2 (underweight) versus persons with BMI ≥18.5kg/m2 (normal or overweight) at treatment initiation and after two months of treatment. Treatment was classified as successful in persons who were free of symptoms and had a negative sputum smear for acid-fast bacilli at the end of the 6-month treatment course. We analysed outcomes using univariable and multivariable logistic regression with 95% CI and p value< 0.05. Results Of enrolled study participants, 184 (40.4%) were underweight and 272 (59.6%) were normal or overweight. Body mass index (BMI ≥18.5kg/m2) at the start and second month of treatment were independent predictors for successful treatment outcome (AOR = 2.15; 95% CI: 1.05, 4.39) and (AOR = 3.55; 95% CI: 1.29, 9.73), respectively. The probability of treatment success among patients with BMI≥18.5kg/m2 at the start and second month of treatment was 92.9% and 97.1%, respectively versus 86.5% and 91.7% in patients with BMI<18.5kg/m2. Bodyweight not adjusted for height and change in the bodyweight after the second and sixth months of treatment were not significantly associated with treatment success. Conclusion In persons treated for TB disease, being underweight at baseline and after two months of treatment was a predictor for unsuccessful treatment outcomes. Nutritional assessment, counselling, and management are important components of TB treatment programs with the potential to improve treatment outcomes.


2007 ◽  
Vol 17 (3) ◽  
pp. 179-183 ◽  
Author(s):  
Igor Sergeyev ◽  
Philip T. Koi ◽  
Stacy L. Jacobs ◽  
Alla Godelman ◽  
David M. Hoenig

2021 ◽  
Vol 6 (6) ◽  
pp. 107-111
Author(s):  
S. M. Kolupayev ◽  
◽  
N. M. Andonieva ◽  
G. V. Lisova

The purpose of the work was to study prognostic factors for the effectiveness of extracorporeal shock wave lithotripsy in patients with ureterolithiasis. Materials and methods. The study included 53 patients with ureteral stones up to 2 cm in size. All patients underwent extracorporeal shock wave lithotripsy under ultrasound control, with a pulse rate of 90 per minute and a maximum number of pulses of 2000 per session. The outcome of treatment was evaluated by ultrasound on day 5 after the extracorporeal shock wave lithotripsy session. If there were stone fragments larger than 5 mm, a second extracorporeal shock wave lithotripsy session was performed. Treatment was considered effective in the absence of stone fragments in the urinary tract 4 weeks after extracorporeal shock wave lithotripsy. Results and discussion. The data were analyzed to identify clinical and radiological factors associated with treatment failure. As a result of the treatment, 46 (86.4%) patients were found to have no stones in the urinary tract (the condition is “stone free”), 9 (13.6%) had stone fragments larger than 5 mm 4 weeks after extracorporeal shock wave lithotripsy, and therefore contact ureterolithotripsy was performed. As complications, 7 (13.2%) patients had an exacerbation of chronic pyelonephritis, which required percutaneous nephrostomy. As the results showed, age, gender, body mass index, and Hausfield units did not differ significantly in terms of extracorporeal shock wave lithotripsy results. Factors that significantly affected the prognosis of extracorporeal shock wave lithotripsy success were the size of the stone and skin-stone distance. Body mass index did not significantly affect the outcome of lithotripsy in this study. The stone density index according to computed tomography data is considered by many authors to be a predictor of the effectiveness of fragmentation, but in our study this indicator was not a significant predictor of the effectiveness of extracorporeal shock wave lithotripsy, which allows us to think that there are other factors, namely the features of the internal structure of the stone, which determine its compliance with the shock wave. Conclusion. The size of the stone and the skin-stone distance are prognostic factors that affect the effectiveness of extracorporeal shock wave lithotripsy in patients with ureterolithiasis. Body mass index and stone density in Hausfield units did not significantly affect extracorporeal shock wave lithotripsy outcome in this study


2021 ◽  
Author(s):  
Lucien Ferndale ◽  
Oluwatosin A Ayeni ◽  
Wenlong Carl Chen ◽  
Colleen Aldous

Abstract BackgroundMost patients presenting with oesophageal cancer to South African institutions present late with advanced disease and are eligible for palliative treatment only. The optimal management of these patients is dependent on their expected survival but factors affecting survival in our setting is unknown. MethodsWe assessed factors influencing survival in patients diagnosed with oesophageal squamous cell carcinoma at Grey's hospital in KwaZulu-Natal, South Africa. Factors assessed for effect on prognosis included patient demographics, clinical and laboratory data and tumour factors. Patients were divided into two groups; those that survived for less than or equal to three months and those that survived for more than three months.Univariate and multivariate analyses were performed to determine which factors significantly influenced whether patients survived for more than three months or not. ResultsA total of 384 patients were entered into the study. There were 218 males with a female to male ratio of 1:1.3. The median survival of the cohort was 3.7 months. One hundred and sixty-one (41.9%) patients survived three months or less, while 223 (58.1%) of patients survived more than three months. Factors that influenced survival on univariate and multivariate analysis were the area of residence, body mass index, serum albumin and performance status.ConclusionArea of residence, body mass index, serum albumin and performance status significantly affect survival in patients treated palliatively for advanced oesophageal cancer at our institution. This knowledge can be used to plan the optimal management algorithm for these patients.


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