scholarly journals Flexible endoscopy with noninvasive ventilation assesses and manages infants with severe bronchopulmonary dysplasia

2021 ◽  
Author(s):  
Wen-Jue Soong ◽  
Pei-Chen Tsao ◽  
Chia-Feng Yang ◽  
Yu-Sheng Lee ◽  
Chieh-Ho Chen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Bronchopulmonary Dysplasia ◽  
Noninvasive Ventilation ◽  
Balloon Dilatation ◽  
Visual Assessment ◽  
Flexible Endoscopy ◽  
Therapeutic Interventions ◽  
Respiratory Care ◽  
Artificial Airway ◽  
Medication Changes

Objectives Flexible endoscopy (FE) assessed the whole approachable aeroesophageal (AE) tracks and changes of management in infants with severe bronchopulmonary dysplasia (sBPD). Methods A 10 years (2011-2020) retrospective study of sBPD infants who had FE with and without artificial airway in AE tracks. FE with noninvasive ventilation (FE-NIV) of pharyngeal oxygen with nose-close and abdomen-compression was supported. Data of found pathologies, changes of consequent management and therapeutic interventions were collected and analyzed. Results Total 42 infants enrolled. Two scopes of 1.8mm and 2.6mm were used. FE revealed 129 AE pathologies in 38 (90.5%) infants. Twenty-eight (66.7%) infants detected more than one lesion. In 35 (83.3%) infants with 111 airway lesions, bronchial granulations (28, 25.2%), tracheomalacia (18, 16.2%) and bronchial granulations (15, 13.5%) were the leadings. Fifteen (35.7%) infants had 18 esophageal lesions. No significant FE-NIV complication noted. FE findings resulted consequent changes of management in all 38 infants. Thirty-six (85.7%) infants involved respiratory care of pressure titrations (29, 45.3%), shorten suctioning depth (17, 26.6%), changed endotracheal or tracheostomy tube depth (10, 15.6%) and extubation (8, 12.5%). Twenty-one (50%) infants had 50 medication changes included add steroids, anti-reflux medicine, antibiotics and stop antibiotics. Eighteen (42.8%) infants had received 37 therapeutic FE-NIV procedures which included 14 balloon dilatation, 13 laser-plasty and 10 stent implantations. Seven (16.7%) infants had surgeries included 4 tracheostomies and 3 fundoplications. Conclusion FE-NIV can be a safe and valuable modality for direct visual assessment of AE pathologies which contributed subsequent changes of clinical management in sBPD infants.

scholarly journals Animal models of bronchopulmonary dysplasia. The term mouse models

2014 ◽  
Vol 307 (12) ◽  
pp. L936-L947 ◽  
Author(s):  
Jessica Berger ◽  
Vineet Bhandari
Keyword(s):  
Animal Models ◽  
Lung Injury ◽  
Mouse Models ◽  
Bronchopulmonary Dysplasia ◽  
Lung Development ◽  
Invasive Mechanical Ventilation ◽  
Therapeutic Interventions ◽  
Contributing Factors ◽  
Short Term ◽  
Injury Models

The etiology of bronchopulmonary dysplasia (BPD) is multifactorial, with genetics, ante- and postnatal sepsis, invasive mechanical ventilation, and exposure to hyperoxia being well described as contributing factors. Much of what is known about the pathogenesis of BPD is derived from animal models being exposed to the environmental factors noted above. This review will briefly cover the various mouse models of BPD, focusing mainly on the hyperoxia-induced lung injury models. We will also include hypoxia, hypoxia/hyperoxia, inflammation-induced, and transgenic models in room air. Attention to the stage of lung development at the timing of the initiation of the environmental insult and the duration of lung injury is critical to attempt to mimic the human disease pulmonary phenotype, both in the short term and in outcomes extending into childhood, adolescence, and adulthood. The various indexes of alveolar and vascular development as well as pulmonary function including pulmonary hypertension will be highlighted. The advantages (and limitations) of using such approaches will be discussed in the context of understanding the pathogenesis of and targeting therapeutic interventions to ameliorate human BPD.

Noninvasive Ventilation for the Prevention of Bronchopulmonary Dysplasia

2016 ◽  
pp. 199-222 ◽  
Author(s):  
Louise S. Owen ◽  
Brett J. Manley ◽  
Vineet Bhandari ◽  
Peter G. Davis
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Noninvasive Ventilation

Vallecular cyst with coexisting laryngomalacia: Successful diagnosis and laser therapy by flexible endoscopy with a novel noninvasive ventilation support in infants

2020 ◽  
Vol 55 (7) ◽  
pp. 1750-1756
Author(s):  
Wen‐Jue Soong ◽  
Chia‐Feng Yang ◽  
Yu‐Sheng Lee ◽  
Pei‐Jeng Tsao ◽  
Chien‐Heng Lin ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Noninvasive Ventilation ◽  
Flexible Endoscopy ◽  
Ventilation Support

Respiratory Care for Spinal Cord Injury

2013 ◽  
Vol 749 ◽  
pp. 258-261
Author(s):  
Yan Chun Zhu ◽  
Jun Chang ◽  
Zhi Gang Sheng
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Spinal Cord Injury ◽  
Therapeutic Interventions ◽  
Respiratory Care ◽  
Respiratory Complications ◽  
Dependency Care ◽  
High Dependency ◽  
Cord Injury ◽  
High Dependency Care

In this paper the issue of respiratory complications following acute spinal cord injury with reference to the area of high dependency care is considered. It will deal with the pathophysiology behind acute spinal cord injury and its effect on the respiratory system, while discussing the interventions used to prevent these complications. A multitude of therapeutic interventions in the care of respiratory complications has been identified. And positioning, chest physiotherapy and assisted coughing techniques will be considered in this paper.

scholarly journals Therapeutic interventions and short-term outcomes for infants with severe bronchopulmonary dysplasia born at <32 weeks’ gestation

2013 ◽  
Vol 33 (11) ◽  
pp. 877-881 ◽  
Author(s):  
M A Padula ◽  
T R Grover ◽  
B Brozanski ◽  
I Zaniletti ◽  
L D Nelin ◽  
...  
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Therapeutic Interventions ◽  
Short Term

Twelve Years' Experience With Bronchopulmonary Dysplasia

PEDIATRICS ◽  
1977 ◽  
Vol 59 (6) ◽  
pp. 839-846 ◽  
Author(s):  
David K. Edwards ◽  
Wayne M. Dyer ◽  
William H. Northway
Keyword(s):  
Mechanical Ventilation ◽  
Retrospective Study ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Bronchopulmonary Dysplasia ◽  
Distress Syndrome ◽  
Stage Iv ◽  
Assisted Ventilation ◽  
Severity Of Disease ◽  
Initial Severity

A retrospective study of 299 successive infants who were ventilated for respiratory distress syndrome (RDS) showed that 62 (21%) developed radiographic stage IV bronchopulmonary dysplasia (BPD). The largest, most mature, and least ill infants tended to survive without developing BPD; the smallest, least mature, and most ill infants tended to die without developing BPD. The patients who developed BPD tended to be intermediate in terms of weight, maturity, and severity of disease; they required longer exposures to elevated oxygen and assisted ventilation than patients who did not develop BPD. The data suggest that in addition to varying individual susceptibility (primarily degree of immaturity and initial severity of disease), elevated oxygen is more important than mechanical ventilation in the pathogenesis of BPD.

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