scholarly journals Prevention of radiation-induced hepatic damage in Swiss albino mice by Aloe Vera leaf extract

2010 ◽  
Vol 25 (3) ◽  
pp. 186-191 ◽  
Author(s):  
Prashasnika Gehlot ◽  
Dhanraj Soyal ◽  
Pradeep Goyal
Keyword(s):  
Lipid Peroxidation ◽  
Alkaline Phosphatase ◽  
Acid Phosphatase ◽  
Leaf Extract ◽  
Aloe Vera ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Albino Mice ◽  
Effects Of Radiation ◽  
Induced Changes

The radioprotective effect of the Aloe vera leaf extract was studied in Swiss albino mice against radiation-induced changes in the liver. The mice were treated with 1000 mg/kg of body weight orally, once a day for 15 consecutive days, before exposure to a single dose of gamma radiation (6 Gy), half an hour after the last administration. The irradiation of mice caused a significant elevation in lipid peroxidation followed by a decrease in glutathione, acid phosphatase and alkaline phosphatase. The treatment of mice before irradiation elevated the glutathione, acid phosphatase and alkaline phosphatase, and was accompanied by a decline in lipid peroxidation. Recovery and regeneration from radiation damage were faster in pretreated animals than the animals in the irradiation-only group. The data clearly indicate that the Aloe vera leaf extract significantly reduced the deleterious effects of radiation on the liver and it could be a useful agent in reducing the side effects of therapeutic radiation.

scholarly journals RADIOPROTECTION OF ALOE VERA AGAINST BIOCHEMICAL ALTERATIONS IN SWISS ALBINO MICE

2018 ◽  
Vol 10 (3) ◽  
pp. 55
Author(s):  
Priyanka Dadupanthi
Keyword(s):  
Radiation Treatment ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aloe Vera ◽  
Radiation Energy ◽  
Tissue Water ◽  
Swiss Albino Mice ◽  
Biochemical Alterations ◽  
Radiation Induced ◽  
Albino Mice

Objective: In this study, radioprotection against radiation-induced hepatic damage in Swiss Albino Mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals.Methods: Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure 0.5, 3 and 5.5 Gy gamma radiation. Mice were autopsied at day ¼, 1, 3, 5,10 and 20 after irradiation to evaluate the radio modulator effect in terms of LPO and GSH.Results: Radiation treatment showed a decrease in GSH content and an increase of LPO in control set animals, however, the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO but values remained below normal.Conclusion: The result of present study suggests that Aloe vera has a radioprotective effect due to their antioxidant and radical scavenging activity.

scholarly journals Protective Effect ofAdhatoda vasciaNees against Radiation-Induced Damage at Cellular, Biochemical and Chromosomal Levels in Swiss Albino Mice

2007 ◽  
Vol 4 (3) ◽  
pp. 343-350 ◽  
Author(s):  
Meenal Kumar ◽  
Ravindra Samarth ◽  
Madhu Kumar ◽  
Senthamil R. Selvan ◽  
Begraj Saharan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Ethanolic Extract ◽  
Reduction Factor ◽  
Swiss Albino Mice ◽  
Unani Medicine ◽  
Radiation Induced ◽  
Albino Mice ◽  
Induced Changes ◽  
Marrow Cells

Extract ofAdhatoda vasica(L) Nees leaves has been used for treatment of various diseases and disorders in Ayurved and Unani medicine. Modulatory effect of ethanolic extract ofA. vasica(L) Nees against radiation-induced changes in terms of histological alterations in testis, reduced glutathione (GSH), lipid peroxidation (LPO), acid and alkaline phosphatases levels, and chromosomal alterations in Swiss albino mice was studied at various post-irradiation intervals between 1 and 30 days. Mice exposed to 8 Gy radiation showed radiation-induced sickness including marked changes in histology of testis and chromosomal aberrations in bone marrow cells with 100% mortality within 22 days. When ethanolic leaf extract ofA. vasicawas given orally at a dose of 800 mg kg−1body weight per mouse for 15 consecutive days and then exposed to radiation, death ofAdhatoda-pretreated irradiated mice was reduced to 70% at 30 days. The radiation dose reduction factor was 1.43. There was significantly lesser degree of damage to testis tissue architecture and various cell populations including spermatogonia, spermatids and Leydig cells. Correspondingly, a significant decrease in the LPO and an increase in the GSH levels were observed in testis and liver ofAdhatoda-pretreated irradiated mice. Similarly, a significant decrease in level of acid phosphatase and increase in level of alkaline phosphatase were observed.Adhatodapretreatment significantly prevented radiation-induced chromosomal damage in bone marrow cells. The study suggests thatAdhatodaplant extract has significant radioprotective effects on testis that warrants further mechanistic studies aimed at identifying the role of major ingredients in the extract.

scholarly journals Effect of Curcumin and Curcumin Copper Complex (1:1) on Radiation-induced Changes of Anti-oxidant Enzymes Levels in the Livers of Swiss Albino Mice

2007 ◽  
Vol 48 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Prabhakar R. KOIRAM ◽  
Veeresh P. VEERAPUR ◽  
Amit KUNWAR ◽  
Beena MISHRA ◽  
Atanu BARIK ◽  
...  
Keyword(s):  
Copper Complex ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Anti Oxidant ◽  
Albino Mice ◽  
Induced Changes

Oral Sequelae of Head and Neck Radiotherapy

2003 ◽  
Vol 14 (3) ◽  
pp. 199-212 ◽  
Author(s):  
A. Vissink ◽  
J. Jansma ◽  
F.K.L. Spijkervet ◽  
F.R. Burlage ◽  
R.P. Coppes
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Normal Tissues ◽  
Radiation Caries ◽  
Temporomandibular Joints ◽  
Clinical Consequences ◽  
Radiation Induced ◽  
Heavy Burden ◽  
Effects Of Radiation ◽  
Induced Changes

In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located in the radiation portals. Oral complications of radiotherapy in the head and neck region are the result of the deleterious effects of radiation on, e.g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints. The clinical consequences of radiotherapy include mucositis, hyposalivation, taste loss, osteoradionecrosis, radiation caries, and trismus. Mucositis and taste loss are reversible consequences that usually subside early post-irradiation, while hyposalivation is normally irreversible. Furthermore, the risk of developing radiation caries and osteoradionecrosis is a life-long threat. All these consequences form a heavy burden for the patients and have a tremendous impact on their quality of life during and after radiotherapy. In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.

scholarly journals Vernonia Amygdalina Del (Bitter Leaf) extract ameliorates isoniazid (INH) induced liver injury in Swiss Albino Mice

2018 ◽  
Author(s):  
Gebreselassie Addisu Tilaye ◽  
Muluken Fekadie Zerihun ◽  
Kasaw Adane Chuffa ◽  
Mahelet Arayaselassie ◽  
Daniel Seifu
Keyword(s):  
Liver Injury ◽  
Leaf Extract ◽  
Drug Clearance ◽  
Vernonia Amygdalina ◽  
Drug Induced ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Antitubercular Drugs ◽  
Toxic Injury ◽  
Albino Mice

AbstractLiver plays a central role in the metabolism of drugs. Drug clearance and transformation exposes liver to toxic injury. Antitubercular drugs have been found to be hepatotoxic and potentially lead to drug-induced liver injury. Isoniazid is one of the most hepatotoxic first line antitubercular drugs. Conventional drugs used in the treatment of liver disease are often inadequate and a search for supplementation or alternative drugs for the treatment of hepatic damage is indispensible. Therefore our study aims to investigate the hepatoprotective potential of Vernonia Amygdalina Del (bitter leaf) extract against Isoniazid-induced liver injury in Swiss Albino Mice. Treatment of Mice orally with Vernonia Amygdalina Del extract at dose of 250mg/kg and 375 mg/kg significantly lowered (P<0.05) the serum level of liver enzymes in Isoniazid pretreated mice. The hepatoptotective activity of the extract found to be comparable with the standard drug, Silymarin (100 mg/kg, P.o.). Moreover, treatment with the extract significantly alleviated Isoniazid induced hepatic injury as supported by the photomicrographs of liver section of mice. The data shows aqueous Vernonia Amygdalina Del extract has a very promising hepatoprotective potential against isoniazid-induced liver injury.

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