scholarly journals Primary hyperfibrinolysis as the presenting sign of prostate cancer: A case report

2016 ◽  
Vol 73 (9) ◽  
pp. 877-880 ◽  
Author(s):  
Andrijana Kulic ◽  
Zorica Cvetkovic ◽  
Vesna Libek
Keyword(s):  
Prostate Cancer ◽  
Case Report ◽  
Fibrinogen Level ◽  
Laboratory Diagnosis ◽  
Cancer Case ◽  
Normal Range ◽  
Normal Ranges ◽  
Assay Result ◽  
The Right ◽  
D Dimer

Introduction. A bleeding syndrome in the setting of primary hyperfibrinolysis in a prostate cancer patient is only 0.40? 1.65% of cases. The laboratory diagnosis of primary hyperfibrinolysis is based on the increase of biomarkers like D-dimer, fibrinogen split products, plasminogen, and euglobulin lysis test. These tests are not specific for primary hyperfibrinolysis. We reported a rare case of hemorrhagic syndrome caused by primary hyperfibrinolysis as the first clinical symptom of metastatic prostate cancer. Case report. A 64-year-old male was admitted to our hospital with large hematomas in the right pectoral and axillary areas (20 x 7 cm), right hemiabdomen (30 x 30 cm) and the left lumbal area, (25 x 5 cm). The patient had no subjective symptoms nor used any medication. Initial coagulation testing, prothrombin time (PT), and activated partial thromboplastin time (APTT) were within the normal range, while fibrinogen level was extremely low (1.068 g/L) (normal range 2.0?5.0) and the D-dimer assay result was high 1.122 mg/L (normal range < 0.23). The results obtained by rotation thrombelastometry pointed to primary fibrinolysis. Further clinical and laboratory examination indicated progressive malignant prostate disease. First line treatment for the patient was a combined administration of tranexamic acid (3 x 500 mg iv) and transfusion of ten units of cryoprecipitate (400 mL). Next day, fibrinolytic function measurements by rotation thrombelastometry were within the normal ranges. Fibrinogen level was normalized within two days (2.4 g/L). There were no newly developed hematomas. Conclusion. This case report shows primary hyperfibrinolysis with bleeding symptoms, which is an uncommon paraneoplastic phenomenon within expanded prostate malignancy. Rotation thrombelastometry in this severe complication helped to achieve the prompt and proper diagnosis and treatment.

Late-onset malignant glaucoma

2020 ◽  
Vol 3 ◽  
pp. 1
Author(s):  
Ramiro José Daud ◽  
Horacio Freile ◽  
Mauricio Freile ◽  
Soledad Mariano
Keyword(s):  
Intraocular Pressure ◽  
Case Report ◽  
Acute Pain ◽  
Late Onset ◽  
Slit Lamp ◽  
Normal Range ◽  
Slit Lamp Examination ◽  
Complete Occlusion ◽  
Malignant Glaucoma ◽  
The Right

A case report on a 49-year-old female with diagnoses of ocular hypertension in her left eye (LE) treated with 250 mg/day acetazolamide for 2 years. During the slit-lamp examination, complete occlusion of both iridocorneal angles was detected. Intraocular pressure (IOP) was 10 and 35 mmHg in the right eye and LE, respectively. Phacotrabeculectomy was performed in the LE. After 1 month of the procedure, the patient developed a slowly progressive miopization from −1 to −3 diopters (D) the following months. Approximately 3 months after surgery, the patient developed an episode of acute pain, athalamia, and IOP 45 mmHg in her LE. Late-onset malignant glaucoma was suspected and the patient was treated with topical hypotensive and cycloplegic agent until a prompt vitrectomy was performed. Deepening of the anterior chamber and restoration of IOP to normal range was obtained after surgery.

Lung and chest wall impedances in the dog in normal range of breathing: effects of pulmonary edema

1992 ◽  
Vol 73 (3) ◽  
pp. 1040-1046 ◽  
Author(s):  
G. M. Barnas ◽  
D. Stamenovic ◽  
K. R. Lutchen
Keyword(s):  
Oleic Acid ◽  
Pulmonary Edema ◽  
Chest Wall ◽  
Mean Airway Pressure ◽  
Normal Range ◽  
Normal Ranges ◽  
Before And After ◽  
Measured Resistance ◽  
The Right ◽  
Severe Pulmonary Edema

We evaluated the effect of pulmonary edema on the frequency (f) and tidal volume (VT) dependences of respiratory system mechanical properties in the normal ranges of breathing. We measured resistance and elastance of the lungs (RL and EL) and chest wall of four anesthetized-paralyzed dogs during sinusoidal volume oscillations at the trachea (50–300 ml, 0.2–2 Hz), delivered at a constant mean airway pressure. Measurements were made before and after severe pulmonary edema was produced by injection of 0.06 ml/kg oleic acid into the right atrium. Chest wall properties were not changed by the injection. Before oleic acid, EL increased slightly with increasing f in each dog but was independent of VT. RL decreased slightly and was independent of VT from 0.2 to 0.4 Hz, but above 0.4 Hz it tended to increase with increasing flow, presumably due to the airway contribution. After oleic acid injection, EL and RL increased greatly. Large negative dependences of EL on VT and of RL on f were also evident, so that EL and RL after oleic acid changed two- and fivefold, respectively, within the ranges of f and VT studied. We conclude that severe pulmonary edema changes lung properties so as to make behavior VT dependent (i.e., nonlinear) and very frequency dependent in the normal range of breathing.

scholarly journals Brucellosis mimicking prostate cancer: Case report and review of the literature

2017 ◽  
Author(s):  
Lütfi Canat ◽  
Akif Erbin ◽  
Hasan Tahsin Gözdaş ◽  
Hasan Anıl Atalay
Keyword(s):  
Prostate Cancer ◽  
Case Report ◽  
Cancer Case ◽  
Prostate Cancer Case ◽  
Review Of The Literature

3 Single shot stereotactic body radiotherapy for localized prostate cancer: Case report

2018 ◽  
Vol 56 ◽  
pp. 2 ◽  
Author(s):  
N. Koutsouvelis ◽  
G. Dipasquale ◽  
A. Dubouloz ◽  
M. Jaccard ◽  
R. Miralbell ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Report ◽  
Stereotactic Body Radiotherapy ◽  
Localized Prostate Cancer ◽  
Cancer Case ◽  
Single Shot ◽  
Prostate Cancer Case

Evolution Of Subclinical Systemic Lymphedema In-Patient With Lipedema And Axillary Dissection

2020 ◽  
Vol 7 (07) ◽  
pp. 4868-4870
Author(s):  
Jose Maria Pereira de Godoy ◽  
Lívia Maria Pereira de Godoy ◽  
Maria de Fatima Guerreiro Godoy
Keyword(s):  
Breast Cancer ◽  
Upper Limb ◽  
Bioelectrical Impedance ◽  
Breast Cancer Case ◽  
Impedance Analysis ◽  
Cancer Case ◽  
Warning Sign ◽  
Normal Range ◽  
The Right ◽  
Surgical Treatments

Background: The surgical treatments of breast cancer associated or not with axillary drainage and radiotherapy constitute the main cause of secondary upper limb lymphedema. Obesity is a particularly aggravating aspect in patients with lymphedema. Novel concepts of subclinical systemic lymphedeman and clinical systemic lymphedema have recently been described. The aim of the present study was to evaluate the evolution of subclinical systemic lymphedema to upper limb lymphedema following treatment for breast cancer. Case: A 36-year-old female patient had been submitted to treatment for breast cancer involving left-side mastectomy and lymph node drainage during a pregnancy three years earlier. She had undergone both chemotherapy and radiotherapy. The patient had a portacath in the right arm for chemotherapy, which was removed after the first evaluation. She was submitted to bioelectrical impedance analysis, which revealed an increase in intracellular and extracellular water and body water in all limbs and the trunk above the normal range. The patient returned approximately two years after the initial evaluation, complaining of edema in the left arm. Conclusion: The treatment of breast cancer in patients with lipedema could lead to the development of subclinical lymphedema in patients with a BMI less than 30 kg/m2. Therefore, such conditions constitute a warning sign for the development of lymphedema.

scholarly journals GnRH agonist induced acute fulminant hepatitis in patient with prostate cancer-case report

2015 ◽  
Vol 26 (2) ◽  
pp. S51
Author(s):  
Yu-Cing Juho ◽  
Sheng-Tang Wu ◽  
Tai-Lung Cha ◽  
Guang-Haun Sun ◽  
Sun-Yran Chang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Report ◽  
Gnrh Agonist ◽  
Fulminant Hepatitis ◽  
Cancer Case ◽  
Prostate Cancer Case

scholarly journals Case Report: Malignant Pheochromocytoma Without Hypertension Accompanied by Increment of Serum VEGF Level and Catecholamine Cardiomyopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Hideaki Kaneto ◽  
Shinji Kamei ◽  
Fuminori Tatsumi ◽  
Masashi Shimoda ◽  
Tomohiko Kimura ◽  
...  
Keyword(s):  
Case Report ◽  
Adrenal Gland ◽  
Tumor Resection ◽  
Left Ventricular ◽  
Malignant Pheochromocytoma ◽  
Left Ventricular Ejection ◽  
Normal Range ◽  
Ventricular Ejection Fraction ◽  
The Right ◽  
Vegf Level

IntroductionPheochromocytoma is a catecholamine-producing tumor in the adrenal medulla and is often accompanied by hypertension, hyperglycemia, hypermetabolism, headache, and hyperhidrosis, and it is classified as benign and malignant pheochromocytoma. In addition, persistent hypertension is often observed in subjects with malignant pheochromocytoma.Case PresentationA 52-year-old Japanese male was referred and hospitalized in our institution. He had a health check every year and no abnormalities had been pointed out. In addition, he had no past history of hypertension. In endocrinology markers, noradrenaline level was as high as 7,693 pg/ml, whereas adrenaline level was within normal range. Abdominal contrast-enhanced computed tomography revealed a 50-mm hyper-vascularized tumor with calcification in the right adrenal gland and multiple hyper-vascularized tumors in the liver. In 131I MIBG scintigraphy, there was high accumulation in the right adrenal gland and multiple accumulation in the liver and bone. In echocardiography, left ventricular ejection fraction was as low as 14.3%. In coronary angiography, however, there was no significant stenosis in the coronary arteries. Based on these findings, we finally diagnosed him as malignant pheochromocytoma accompanied by multiple liver and bone metastases and catecholamine cardiomyopathy. However, blood pressure was continuously within normal range without any anti-hypertensive drugs. Right adrenal tumor resection was performed together with left hepatic lobectomy and cholecystectomy. Furthermore, serum levels of vascular endothelial growth factor (VEGF) and parathyroid (PTH)-related protein were very high before the operation but they were markedly reduced after the operation.ConclusionsThis is the first report showing the time course of serum VEGF level in a subject with malignant pheochromocytoma, clearly showing that malignant pheochromocytoma actually secreted VEGF. In addition, this case report clearly shows that we should bear in mind once again that malignant pheochromocytoma is not necessarily accompanied by hypertension.

scholarly journals Laparoscopic port-site metastasis as the manifestation of neuroendocrine prostate cancer: Case report and literature review

2019 ◽  
Vol 24 ◽  
pp. 100845
Author(s):  
Ana María Gómez González ◽  
Daniel Mantilla Rey ◽  
Ana María Ortiz Zableh ◽  
Catalina de Valencia ◽  
Nicolás Villareal Trujillo
Keyword(s):  
Prostate Cancer ◽  
Case Report ◽  
Literature Review ◽  
Port Site ◽  
Cancer Case ◽  
Prostate Cancer Case ◽  
Port Site Metastasis ◽  
Laparoscopic Port ◽  
Neuroendocrine Prostate Cancer
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