Is Imagery a Functional Component of the "Bizarre Imagery" Phenomenon?

1994 ◽  
Vol 107 (2) ◽  
pp. 207 ◽  
Author(s):  
D. Chris Anderson ◽  
Linda S. Buyer
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cuilan Hou ◽  
Junmin Zheng ◽  
Wei liu ◽  
Lijian Xie ◽  
Xiaomin Sun ◽  
...  

AbstractCongenital heart defects, one of the most common birth defects, affect approximately 1% of live birth globally and remain the leading cause of infant mortality in developed countries. Utilizing the pathogenicity score and inheritance mode from whole exome sequencing results, a heterozygous mutation (NM_001278939.1: c.1939G>T, p.Gly647Ter) in elastin (ELN) was identified among 6,440 variants in a female proband born with an atrial septal defect accompanied by pulmonary artery stenosis. Results of RT-PCR showed that the mutation (NM_001278939.1: c.1939G>T, p.Gly647Ter) did not affect the expression levels of ELN mRNA but increased protein level. The content of ELN truncate (functional component) was significantly lower in both the intracellular and extracellular compartments after mutation. These results indicate that the ELN mutation (NM_001278939.1: c.1939G>T, p.Gly647Ter) affected the protein truncate, which may be a functional component of ELN and play crucial roles for this pedigree. Here we report of an ELN heterozygous variant associated with congenital heart disease accompanied with pulmonary artery stenosis, which is less common. Based on our results, we speculate that this may be the main molecular mechanism underlying the mutation-led functional changes, and propose that the decrease of ELN protein level may cause this pedigree vascular abnormality, especially pulmonary artery stenosis, and reinforce the view that ELN insufficiency is the primary cause of these vascular lesions. This may be the main molecular mechanism underlying the mutation-led functional changes. Thus, systematic analysis not only enables us to better understand the etiology of this disease but also contributes to clinical and prenatal diagnosis.


2004 ◽  
Vol 57 (3) ◽  
pp. 275-290 ◽  
Author(s):  
Carmen Sáenz ◽  
Elena Sepúlveda ◽  
Betty Matsuhiro

2017 ◽  
Vol 21 (5) ◽  
pp. 62-69 ◽  
Author(s):  
E. V. Pozdnyakova ◽  
N. S. Kobelev ◽  
A. L. Pozdnyakov

The article describes the process of transforming the industrial model of the school into a modern one. The conclusion is made about the influence of the development of the educational process on the formation of architecture and space-planning decisions of buildings. The increase in the nomenclature of classrooms is directly related to the complexity of the structure of the school and its functional component. Also, modern trends in the design of school buildings are described. The space of schools is considered as a multifaceted structure, combining both places for study, and for rest. The problem of expanding and deepening the information space is analyzed, and ways of its solution are suggested. The main principles of designing public school zones, their division into different-scale volumes are described in detail. Conclusions are made about the requirements for modern school buildings to ensure their compliance with the aesthetic needs of the student's personality. The main problems that are present in the modern school fund are analyzed and possible options for its reconstruction are analyzed. Also, the principles of reconstruction in accordance with the types of planning organization are developed. Examples of solutions to some of these problems are given, and the issue of creating comfortable conditions for people with disabilities is separately highlighted. A conclusion is made about the effectiveness of applying these principles to ensure the modern learning process.


2018 ◽  
Vol 102 (11) ◽  
pp. 4653-4662
Author(s):  
Hongwei Guo ◽  
Tianqiu Huang ◽  
Jun Zhao ◽  
Hongwen Chen ◽  
Guo Chen

2021 ◽  
pp. 49-52
Author(s):  
Ya.M. Uzakov ◽  
Sh. Y. Kenenbai ◽  
O.N. Kuznetsova ◽  
T. R. Koshoeva ◽  
A.N. Yesengazieva ◽  
...  
Keyword(s):  

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