Permanent Poliosis following Repetitive Plucking in an Adolescent

Background and Objective: Poliosis is an inherited or acquired loss of pigment from a group of closely positioned hair follicles characterized by a patch of white hair. It is commonly seen in vitiligo, piebaldism, Waardenburg syndrome, Vogt-Koyanagi-Harada syndrome, Griscelli syndrome, and Apert syndrome. We investigated a male manifesting poliosis on the chin after repetitive plucking. Conclusion: To our knowledge, poliosis induced by repeated plucking has never been documented.

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The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice

International Journal of Molecular Sciences ◽

10.3390/ijms20112665 ◽

2019 ◽

Vol 20 (11) ◽

pp. 2665 ◽

Cited By ~ 1

Author(s):

Keiichi Hiramoto ◽

Yurika Yamate ◽

Yutaka Takishita ◽

Eisuke F. Sato

Keyword(s):

Tranexamic Acid ◽

Transforming Growth Factor ◽

Hair Follicles ◽

White Hair ◽

Black Hair ◽

Melanocortin Receptor ◽

Control Group ◽

Hair Color ◽

Collagen Xvii ◽

Acid Administration

We observed that on long-term breeding, gp91phox-knockout (gp91phox−/−) mice developed white hair. Here, we investigate the origin of this hitherto unexplained phenomenon. Moreover, we investigated the effect of tranexamic acid administration on the hair color in gp91phox−/− mice. We administered tranexamic acid (about 12 mg/kg/day) orally to 9-week-old C57BL/6j (control) and gp91phox−/− mice, thrice a week for 12 months. Compared to control mice, gp91phox−/− mice showed more white hair. However, the concentrations of reactive oxygen species and the levels of interleukin (IL)-1β and transforming growth factor (TGF)-β in the skin were lower than those in the control group. Furthermore, increase in white hair was observed in the control mice upon administration of the IL-1β antagonist. On the other hand, administration of tranexamic acid led to brown colored hair on gp91phox−/− mice. Although tranexamic acid treatment did not alter the expression levels of melanocortin receptor 1 and agouti signaling protein on hair follicles, it increased the expression of mahogunin ring finger protein 1 (MGRN1) and collagen XVII. These results suggested that retention of black hair requires the gp91phox/ROS/IL-1β/TGF-β pathway and that elevated levels of MGRN1 and collagen XVII lead to brown hair in gp91phox−/− mice.

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MITF p.Arg217Thr Variant Identified in a Han Chinese Family with Tietz/Waardenburg Syndrome

BioMed Research International ◽

10.1155/2021/4381272 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Rong Yu ◽

Lv Liu ◽

Ya-Li Li ◽

Liang-Liang Fan

Keyword(s):

Hearing Loss ◽

Genetic Disorders ◽

Molecular Genetic ◽

Genetic Diagnosis ◽

Han Chinese ◽

White Hair ◽

Chinese Family ◽

Waardenburg Syndrome ◽

Genetic Lesion

Waardenburg syndrome (WS) is a group of rare genetic disorders characterized by hearing loss, changes in coloring of hair, skin, and eyes, and alterations in the shape of the face. Tietz syndrome is another rare disorder which presented similar phenotypes to WS. Patients with Tietz/Waardenburg syndrome often present with pale blue eyes, albino skin, and distinctive hair coloring, such as a patch of white hair or hair that prematurely turns gray. At present, more than six candidate genes are responsible for four types of Waardenburg syndrome and Tietz syndrome. This study is aimed at identifying the pathogenic gene variants in a three-generation Han Chinese family with hearing loss, blue-gray iris, albino skin, and white hair. In order to discover the molecular genetic lesion underlying the disease phenotype, whole exome sequencing in the proband, with Tietz/Waardenburg syndrome phenotypes, of a Han Chinese family from HeBei, China, was conducted. A novel heterozygous c.650G>C/p.Arg217Thr variant in melanocyte inducing transcription factor (MITF) was identified. Sanger sequencing further validated that this mutation existed in three affected individuals and absent in healthy family members. Bioinformatics analysis predicted that this mutation was deleterious. Our study further identified the genetic lesion of the family. Simultaneously, our study may also contribute to genetic counseling, embryonic screening of in vitro fertilized embryos, and prenatal genetic diagnosis of patients with Tietz/Waardenburg syndrome, especially for the proband, unmarried and unpregnant women, to reduce familial transmission in this Han Chinese family.

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Preservation of melanoblasts of white hair follicles of segmental vitiligo lesions: A preliminary study

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/j.1468-3083.2010.03710.x ◽

2010 ◽

Vol 25 (2) ◽

pp. 240-242 ◽

Cited By ~ 3

Author(s):

HJ Song ◽

GS Choi ◽

JH Shin

Keyword(s):

Hair Follicles ◽

White Hair ◽

Preliminary Study

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Visualization of Internal Skin Structures with the Scanning Electron Microscope

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100062130 ◽

1969 ◽

Vol 27 ◽

pp. 46-47

Author(s):

Emil Bernstein

Keyword(s):

Electron Microscope ◽

Scanning Electron Microscope ◽

Great Depth ◽

Hair Follicles ◽

Depth Of Field ◽

Pig Skin ◽

Realistic Picture ◽

Main Components ◽

Scanning Electron

An interesting method for examining structures in g. pig skin has been developed. By modifying an existing technique for splitting skin into its two main components—epidermis and dermis—we can in effect create new surfaces which can be examined with the scanning electron microscope (SEM). Although this method is not offered as a complete substitute for sectioning, it provides the investigator with a means for examining certain structures such as hair follicles and glands intact. The great depth of field of the SEM complements the technique so that a very “realistic” picture of the organ is obtained.

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