Association Between Body Fat Mass and Plasma Insulin Level in the Male Patients with Idiopathic Hypogonadotropic Hypogonadism and Normal Glucose Tolerance

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1972-P
Author(s):  
XUBIN YANG ◽  
QIONGYAN LIN ◽  
XILING HU ◽  
WEN XU ◽  
HONG R. DENG
Keyword(s):  
Glucose Tolerance ◽  
Body Fat ◽  
Fat Mass ◽  
Plasma Insulin ◽  
Hypogonadotropic Hypogonadism ◽  
Insulin Level ◽  
Normal Glucose Tolerance ◽  
Body Fat Mass ◽  
Normal Glucose ◽  
Male Patients

scholarly journals Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders

2019 ◽  
Author(s):  
Jing Zheng ◽  
Juan Liu ◽  
Beverly S Hong ◽  
Yanbing Li
Keyword(s):  
Adipose Tissue ◽  
Glucose Tolerance ◽  
Body Fat ◽  
Lower Limb ◽  
Fat Distribution ◽  
Normal Glucose Tolerance ◽  
Body Fat Distribution ◽  
The Body ◽  
Enzyme Linked Immunosorbent Assay ◽  
Normal Glucose

Abstract Background: The relationship between betatrophin/ANGPTL8 and obesity has been investigated using body mass index (BMI); however, since BMI reflects overall adiposity rather than body fat distribution, it remains unclear whether fat deposition in different areas of the body affects betatrophin expression. Here, we investigated the correlation between circulating betatrophin levels and body fat distribution in patients with different glucose tolerance. Methods: In 128 participants with impaired glucose tolerance (IGT; n = 64) or normal glucose tolerance (NGT; n = 64), we measured circulating betatrophin levels by enzyme-linked immunosorbent assay and body fat distribution (subcutaneous, visceral, and limb fat) using magnetic resonance imaging (MRI) and a body fat meter. Results: After controlling for age, sex, and BMI, betatrophin was correlated positively with visceral adipose tissue-to-subcutaneous adipose tissue ratio ( VAT/SAT ratio; r = 0.339, p = 0.009) and negatively with body fat ratio (BFR; r = -0.275, p = 0.035), left lower limb fat ratio (LLR; r = -0.330, p = 0.011), and right lower limb fat ratio (RLR; r = -0.288, p = 0.027) in the NGT group, with these correlations remaining after controlling for triglycerides. VAT/SAT ratio (standardized β = 0.419, p = 0.001) was independently associated with serum betatrophin levels; however, betatrophin was not associated with body fat distribution variables in the IGT group. Conclusions: Circulating betatrophin levels correlated positively with VAT/SAT ratio and negatively with lower limb fat, but not subcutaneous or upper limb fat, in individuals with normal glucose tolerance. Thus, betatrophin may be a poten­tial biomarker for body fat distribution in individuals without glucose disorders.

PLASMA CORTICOSTEROID, PLASMA INSULIN AND BLOOD SUGAR OF NORMAL FASTING AND DIABETIC SUBJECTS WITH OR WITHOUT HYPERCORTICISM

1968 ◽  
Vol 58 (4) ◽  
pp. 643-654 ◽  
Author(s):  
Vivian Harding Asfeldt ◽  
Kai R. Jørgensen
Keyword(s):  
Glucose Tolerance ◽  
Blood Sugar ◽  
Plasma Insulin ◽  
Insulin Response ◽  
Tolerance Test ◽  
Normal Glucose Tolerance ◽  
Oral Glucose ◽  
Acth Stimulation ◽  
Normal Glucose ◽  
Plasma Insulin Response

ABSTRACT Transient, maximum stimulation with β1–24 corticotrophin has been carried out in nine normal fasting subjects, in two fasting diabetics without hypercorticism and in three fasting diabetics with hypercorticism. Fluorimetric determinations of corticosteroids and determinations of immunological detectable insulin in plasma and blood sugar were made during stimulation. No significant variation in the blood sugar or the plasma insulin during transient, maximum ACTH stimulation was found either in normal fasting subjects or in fasting diabetics with or without hypercorticism. Moreover, in two diabetics with hypercorticism the plasma insulin response was measured during an oral glucose tolerance test. After treatment for approximately seven months with glucocorticosteroids, a reduced glucose tolerance and an increased plasma insulin response were found in one of these two patients. Four and a half months after the termination of steroid treatment, normal glucose tolerance and normal insulin responses were observed. In one patient, after several years of hypercorticism, a reduced glucose tolerance and a markedly reduced plasma insulin response were found.

scholarly journals Impact of body fat percentage change on future diabetes in subjects with normal glucose tolerance

IUBMB Life ◽  
2017 ◽  
Vol 69 (12) ◽  
pp. 947-955 ◽  
Author(s):  
Tianxue Zhao ◽  
Ziwei Lin ◽  
Hui Zhu ◽  
Chen Wang ◽  
Weiping Jia
Keyword(s):  
Glucose Tolerance ◽  
Body Fat ◽  
Normal Glucose Tolerance ◽  
Percentage Change ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Normal Glucose ◽  
Future Diabetes

Plasma insulin and blood pressure in normotensive Japanese men with normal glucose tolerance

1995 ◽  
Vol 13 (4) ◽  
pp. 427???432 ◽  
Author(s):  
Katsuyuki Miura ◽  
Hideaki Nakagawa ◽  
Muneko Nishijo ◽  
Masaji Tabata ◽  
Yuko Morikawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Tolerance ◽  
Plasma Insulin ◽  
Normal Glucose Tolerance ◽  
Japanese Men ◽  
Normal Glucose
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