scholarly journals Closing in on the Mechanisms of Pulsatile Insulin Secretion

Diabetes ◽  
2018 ◽  
Vol 67 (3) ◽  
pp. 351-359 ◽  
Author(s):  
Richard Bertram ◽  
Leslie S. Satin ◽  
Arthur S. Sherman
Keyword(s):  
Insulin Secretion ◽  
Pulsatile Insulin Secretion

Pulsatile insulin secretion from isolated human pancreatic islets

Diabetes ◽  
1994 ◽  
Vol 43 (6) ◽  
pp. 827-830 ◽  
Author(s):  
P. Marchetti ◽  
D. W. Scharp ◽  
M. Mclear ◽  
R. Gingerich ◽  
E. Finke ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Islets ◽  
Human Pancreatic Islets ◽  
Pulsatile Insulin Secretion

scholarly journals Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in G�ttingen minipigs

Diabetologia ◽  
2004 ◽  
Vol 47 (1) ◽  
pp. 155-155
Author(s):  
M. O. Larsen ◽  
C. F. Gotfredsen ◽  
M. Wilken ◽  
R. D. Carr ◽  
N. P�rksen ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Pulsatile Insulin Secretion

Altered pulsatile insulin secretion associated with endurance training

1995 ◽  
Vol 79 (6) ◽  
pp. 1977-1985 ◽  
Author(s):  
J. H. Engdahl ◽  
J. D. Veldhuis ◽  
P. A. Farrell
Keyword(s):  
Insulin Secretion ◽  
Endurance Exercise ◽  
Venous Blood ◽  
Oral Glucose ◽  
Target Tissue ◽  
O2 Consumption ◽  
Pulse Profile ◽  
Plasma Insulin Concentration ◽  
Deconvolution Analysis ◽  
Pulsatile Insulin Secretion

Endurance exercise training reduces glucose-stimulated insulin secretion while elevating insulin action on target tissues. Under some conditions, hormone action is enhanced by pulsatile delivery to tissues. We tested the hypothesis that different insulin secretory pulse profiles would be observed in endurance-trained vs. sedentary men. Seven endurance-trained [T; maximal O2 consumption 62.5 +/- 4.3 (SD) ml.kg-1.min-1)] and seven untrained (UT; maximal O2 consumption 40.3 +/- 3.3 ml.kg-1.min-1) age- and weight-matched men were studied. All subjects had normal oral glucose-tolerance tests; however, the insulin responses for the T subjects were significantly lower than for the UT subjects (P < 0.05). After 2 days of no exercise and an overnight fast, arterialized venous blood was sampled at 1-min intervals for 120 min and assayed for insulin. Characteristics of the insulin pulse profile were quantified with deconvolution analysis. The mass of insulin secreted per burst was significantly lower for the T than for the UT subjects (50.1 +/- 14 vs. 107.4 +/- 35 pM; P < 0.05), as was the peak height per burst (14.3 +/- 5 vs. 37.5 +/- 3.2 pM), rate of insulin production (429.6 +/- 161 vs. 1,002.4 +/- 393 pmol/90 min), and mean plasma insulin concentration (32.2 +/- 17 vs. 53.7 +/- 35 pM). The interpulse interval between bursts and the half-duration of insulin secretory bursts were not significantly different between the groups. Nonpulsatile basal insulin secretion was similar for the T and UT subjects (3.58 +/- 1.6 vs. 5.55 +/- 2.3 pM/min). These data show that regular endurance exercise in young men is associated with an insulin pulse profile in the resting fasted state characterized by less insulin secreted per burst but a similar number of bursts over a 90-min period. As a working hypothesis, we suggest that training-induced elevations in target-tissue sensitivity to insulin reduce the requirement for pulsatile insulin secretion.

scholarly journals Pulsatile Insulin Secretion by Human Pancreatic Islets

2002 ◽  
Vol 87 (1) ◽  
pp. 213-221 ◽  
Author(s):  
Soon H. Song ◽  
Lise Kjems ◽  
Robert Ritzel ◽  
Susan M. McIntyre ◽  
Michael L. Johnson ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Islets ◽  
Human Pancreatic Islets ◽  
Pulsatile Insulin Secretion

IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates

1997 ◽  
Vol 272 (3) ◽  
pp. E352-E358 ◽  
Author(s):  
N. Porksen ◽  
M. A. Hussain ◽  
T. L. Bianda ◽  
B. Nyholm ◽  
J. S. Christiansen ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Low Dose ◽  
Insulin Concentration ◽  
Enzyme Linked Immunosorbent Assay ◽  
High Dose ◽  
Specific Inhibition ◽  
Igf I ◽  
Concentration Time Series ◽  
Functional Features ◽  
Pulsatile Insulin Secretion

Insulin-like growth factor I (IGF-I) shares structural and functional features with insulin, affects carbohydrate metabolism, and inhibits insulin secretion. Insulin secretion is pulsatile, and it is regulated by changing frequency and/or mass of secretory bursts. To examine the mechanism of IGF-I's inhibition of insulin secretion, eight healthy volunteers were studied three times. During glucose infusion (2.5 mg x kg(-1) x min(-1)) blood was sampled minutely at time 75-200 min for triplicate insulin concentration measurements by enzyme-linked immunosorbent assay (ELISA; coefficient of variation 2.1%). Time 125 min infusion of saline, low-dose IGF-I (0.025 microg x kg(-1) x min(-1)) or high-dose IGF-I (0.15 microg x kg(-1) x min(-1)) was commenced and continued until 200 min. Data were compared before (75-125 min) vs. during infusion (150-200 min). Insulin concentration time series were deconvolved, using validated pulse-detection criteria, to assess insulin secretory burst mass and frequency. During saline infusion no time effect occurred. After IGF-I infusion, serum C-peptide decreased (582 +/- 85 vs. 481 +/- 82 pM, low-dose IGF-I, P < 0.05; 539 +/- 84 vs. 427 +/- 69 pM, high-dose IGF-I, P < 0.01). Total insulin secretion rates decreased by 17 and 21%, respectively, via specific inhibition of the insulin secretory burst mass (31 +/- 8 vs. 20 +/- 4 pmol/ml, low-dose IGF-I, P = 0.06; 22 +/- 4 vs. 17 +/- 3 pmol/ml, high-dose IGF-I, P < 0.05), whereas the frequency was not affected (10.5 +/- 1.3 vs. 10.7 +/- 1.3 pulses/h, low-dose IGF-I, P = 0.85; 8.7 +/- 1.0 vs. 11.1 +/- 1.2 min/pulse, high-dose IGF-I, P = 0.15). We conclude that IGF-I inhibits pulsatile insulin secretion by specific inhibition of mass but not frequency of secretory bursts.

scholarly journals Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion

Science ◽  
2017 ◽  
Vol 355 (6326) ◽  
pp. eaah6171 ◽  
Author(s):  
Joshua A. Lees ◽  
Mirko Messa ◽  
Elizabeth Wen Sun ◽  
Heather Wheeler ◽  
Federico Torta ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Insulin Secretion ◽  
Lipid Transport ◽  
Membrane Contacts ◽  
Pulsatile Insulin Secretion

scholarly journals Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency

Diabetes Care ◽  
2000 ◽  
Vol 23 (5) ◽  
pp. 675-681 ◽  
Author(s):  
C. B. Juhl ◽  
N. Porksen ◽  
M. Hollingdal ◽  
J. Sturis ◽  
S. Pincus ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Burst Frequency ◽  
Pulsatile Insulin Secretion
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