Vibration Perception Threshold as a Measure of Distal Symmetrical Peripheral Neuropathy in Type 1 Diabetes: Results from the DCCT/EDIC study

Foot ulcers, infections, and deformity are some of the major sources of mortality and morbidity among the diabetic population. The relationship between glycated hemoglobin (HbA1c) and diabetic peripheral neuropathy (DPN) has been well established. There is a dearth of literature on the relationship between vibration perception threshold (VPT) and HbA1c values. So, the objective of the study was to determine the strength of linear relationship between HbA1c levels and vibration perception threshold in DPN. This cross-sectional study was conducted at Kasturba Hospital, Manipal, and diabetic foot screening camps held at various parts of Udupi district. Ethical approval was obtained from the Institutional Ethics Committee, Kasturba Hospital, Manipal (IEC:281/2017). A total of 534 participants ranging from 30 to 70 years of age and were diagnosed with type 2 diabetes mellitus on medications were included in the study. Neuropathy assessment consisting of monofilament and vibration perception threshold was done using Neurotouch beta version (Yostra Labs, Bengaluru, India). HbA1c measurement was done using turbidimetric inhibition immunoassay technique (Roche Diagnostics, Mannheim, Germany). Pearson correlation coefficient showed a moderate to good correlation between HbA1c and VPT ( r = .0.753, P < .001). Linear regression result has shown a significant relationship of VPT with HbA1c (4.033 [95% confidence interval = 3.67-4.39]). The present study has concluded that there is strong relationship between HbA1c values and VPT and could be a predictor for complications in the foot following DPN.

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The Semmes -Weinstein monofilament examination as a single effective screening tool in the evaluation of diabetic peripheral neuropathy when compared to vibration perception threshold

National Journal of Physiology Pharmacy and Pharmacology ◽

10.5455/njppp.2020.10.03076202028032020 ◽

2020 ◽

pp. 1

Author(s):

Subathra Ammaiyappan ◽

Babitha Rangarajan

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Screening Tool ◽

Perception Threshold ◽

Vibration Perception Threshold ◽

Effective Screening ◽

Vibration Perception

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Assessment of Peripheral Neuropathy Using Measurement of the Current Perception Threshold with the Neurometer® in patients with type 1 diabetes mellitus

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2015.04.018 ◽

2015 ◽

Vol 109 (1) ◽

pp. 130-134 ◽

Cited By ~ 8

Author(s):

Sheng-long Lv ◽

Chen Fang ◽

Ji Hu ◽

Yun Huang ◽

Bo Yang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Peripheral Neuropathy ◽

Type 1 Diabetes Mellitus ◽

Perception Threshold ◽

Current Perception Threshold

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A Comparison of the New Indicator Test for Sudomotor Function (Neuropad®) with the Vibration Perception Threshold and the Clinical Examination in the Diagnosis of Peripheral Neuropathy in Subjects with Type 2 Diabetes

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2007-984455 ◽

2007 ◽

Vol 116 (02) ◽

pp. 135-138 ◽

Cited By ~ 23

Author(s):

N. Papanas ◽

K. Papatheodorou ◽

D. Papazoglou ◽

C. Monastiriotis ◽

D. Christakidis ◽

...

Keyword(s):

Type 2 Diabetes ◽

Peripheral Neuropathy ◽

Clinical Examination ◽

Perception Threshold ◽

Vibration Perception Threshold ◽

Sudomotor Function ◽

Vibration Perception

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Study to assess neuropathy severity in patients with diabetic foot problems

International Surgery Journal ◽

10.18203/2349-2902.isj20204686 ◽

2020 ◽

Vol 7 (11) ◽

pp. 3762

Author(s):

Someshwara Rao Pallela Narayana

Keyword(s):

Diabetic Foot ◽

Sampling Technique ◽

Foot Care ◽

Perception Threshold ◽

Vibration Perception Threshold ◽

Charcot Neuroarthropathy ◽

Painful Sensation ◽

Foot Problems ◽

Vibration Perception

Background: Diabetic neuropathy is the most common complication of diabetes affecting 50% of the patients with type 1 and type 2 diabetes. Its late sequelae which include foot ulceration, charcot neuroarthropathy and occasionally amputation, should in many cases be preventable. Biothesiometry is a device which can measure the vibration perception threshold and guide the treatment as well as prevent further foot problems in such patients.Methods: In this study we included 65 patients with diabetic foot symptoms by random sampling technique between the age group of 40-75 years. All these patients were subjected to biothesiometer testing. The response was measured as vibration perception threshold (VPT). The variation of VPT in different conditions was established.Results: Among 65 patients, 40(61%) patients had painful sensation, VPT ranging from 16 V to 25 V, 6 (0.09%) patients had callus, dry foot or pigmentation with VPT 25-35 V, 12 (18.4%) patients had callus ulcer with VPT 36-45 V, 3 (0.046%) patients had both ulcer and skin changes with VPT 45-50 V and 4 (0.06%) patients presented with deformity and VPT 50 V.Conclusions: The study concluded that risk of ulceration is high with increased VPT. Hence, early detection of raised VPT would help the clinicians not only to guide the patients about the high risk of ulceration but it as well will help in educating the patient and emphasizing the need for proper glycemic control, proper footwear and foot care.

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