scholarly journals Comment on Weber et al. Type 1 Diabetes Is Associated With an Increased Risk of Fracture Across the Life Span: A Population-Based Cohort Study Using The Health Improvement Network (THIN). Diabetes Care 2015;38:1913–1920

Diabetes Care ◽  
2015 ◽  
Vol 38 (12) ◽  
pp. e204-e204 ◽  
Author(s):  
Viral N. Shah
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Life Span ◽  
Diabetes Care ◽  
Population Based ◽  
Health Improvement ◽  
Risk Of Fracture ◽  
Increased Risk ◽  
The Health Improvement Network

scholarly journals Incidence and risk of celiac disease after type 1 diabetes: A population‐based cohort study using the health improvement network database

2018 ◽  
Vol 19 (8) ◽  
pp. 1422-1428 ◽  
Author(s):  
Mary Ellen Vajravelu ◽  
Ron Keren ◽  
David R. Weber ◽  
Ritu Verma ◽  
Diva D. De León ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Celiac Disease ◽  
Population Based ◽  
Health Improvement ◽  
Network Database ◽  
The Health Improvement Network

Incidence and Risk of Celiac Disease in Individuals with Type 1 Diabetes over the Lifespan—A Population-Based Cohort Study Using the Health Improvement Network Database

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1498-P
Author(s):  
MARY ELLEN VAJRAVELU ◽  
DIVA DE LEON ◽  
DAVID R. WEBER ◽  
RON KEREN ◽  
MICHELLE R. DENBURG ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Celiac Disease ◽  
Population Based ◽  
Health Improvement ◽  
Network Database ◽  
The Health Improvement Network

scholarly journals Maternal and child gluten intake and risk of type 1 diabetes: The Norwegian Mother and Child Cohort Study

2019 ◽  
Author(s):  
Nicolai A Lund-Blix ◽  
German Tapia ◽  
Karl Mårild ◽  
Anne Lise Brantsaeter ◽  
Pål R Njølstad ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Confidence Interval ◽  
Population Based ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
Pregnancy Cohort ◽  
Increased Risk ◽  
Mother And Child

ABSTRACTOBJECTIVETo examine the association between maternal and child gluten intake and risk of type 1 diabetes in children.DESIGNPregnancy cohortSETTINGPopulation-based, nation-wide study in NorwayPARTICIPANTS86,306 children in The Norwegian Mother and Child Cohort Study born from 1999 through 2009, followed to April 15, 2018.MAIN OUTCOME MEASURESClinical type 1 diabetes, ascertained in a nation-wide childhood diabetes registry. Hazard ratios were estimated using Cox regression for the exposures maternal gluten intake up to week 22 of pregnancy and child’s gluten intake when the child was 18 months old.RESULTSDuring a mean follow-up of 12.3 years (range 0.7-16.0), 346 children (0.4%) developed type 1 diabetes (incidence rate 32.6 per 100,000 person-years). The average gluten intake was 13.6 grams/day for mothers during pregnancy, and 8.8 grams/day for the child at 18 months of age. Maternal gluten intake in mid-pregnancy was not associated with the development of type 1 diabetes in the child (adjusted hazard ratio 1.02 (95% confidence interval 0.73 to 1.43) per 10 grams/day increase in gluten intake). However, the child’s gluten intake at 18 months of age was associated with an increased risk of later developing type 1 diabetes (adjusted hazard ratio 1.46 (95% confidence interval 1.06 to 2.01) per 10 grams/day increase in gluten intake).CONCLUSIONSThis study suggests that the child’s gluten intake at 18 months of age, and not the maternal intake during pregnancy, could increase the risk of type 1 diabetes in the child.WHAT IS ALREADY KNOWN ON THIS TOPICA national prospective cohort study from Denmark found that a high maternal gluten intake during pregnancy could increase the risk of type 1 diabetes in the offspring (adjusted hazard ratio 1.31 (95% confidence interval 1.001 to 1.72) per 10 grams/day increase in gluten intake). No studies have investigated the relation between the amount of gluten intake by both the mother during pregnancy and the child in early life and risk of developing type 1 diabetes in childhood.WHAT THIS STUDY ADDSIn this prospective population-based pregnancy cohort with 86,306 children of whom 346 developed type 1 diabetes we found that the child’s gluten intake at 18 months of age was associated with the risk of type 1 diabetes (adjusted hazard ratio 1.46 (95% confidence interval 1.06 to 2.01) per 10 grams/day increase in gluten intake). This study suggests that the child’s gluten intake at 18 months of age, and not the maternal intake during pregnancy, could increase the child’s risk of type 1 diabetes.

scholarly journals Enterovirus infection is associated with an increased risk of childhood type 1 diabetes in Taiwan: a nationwide population-based cohort study

Diabetologia ◽  
2014 ◽  
Vol 58 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Hsiao-Chuan Lin ◽  
Chung-Hsing Wang ◽  
Fuu-Jen Tsai ◽  
Kao-Pin Hwang ◽  
Walter Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Population Based ◽  
Enterovirus Infection ◽  
Increased Risk ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

scholarly journals Risk of Fracture in Urolithiasis: A Population-Based Cohort Study Using the Health Improvement Network

2014 ◽  
Vol 9 (12) ◽  
pp. 2133-2140 ◽  
Author(s):  
Michelle R. Denburg ◽  
Mary B. Leonard ◽  
Kevin Haynes ◽  
Shamir Tuchman ◽  
Gregory Tasian ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Health Improvement ◽  
Risk Of Fracture ◽  
The Health Improvement Network

scholarly journals Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0226997 ◽  
Author(s):  
Yi-Hao Peng ◽  
Yu-Sheng Lin ◽  
Chia-Hung Chen ◽  
Kun-Yuan Tsai ◽  
Yi-Chih Hung ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Venous Thromboembolism ◽  
Population Based ◽  
Increased Risk

Chronic comorbidities in children with type 1 diabetes: a population-based cohort study

2015 ◽  
Vol 100 (8) ◽  
pp. 763-768 ◽  
Author(s):  
Soulmaz Fazeli Farsani ◽  
Patrick C Souverein ◽  
Marja M J van der Vorst ◽  
Catherijne A J Knibbe ◽  
Anthonius de Boer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Hazard Analysis ◽  
Population Based ◽  
Early Years ◽  
Increased Risk ◽  
Significant Difference ◽  
Reference Cohort ◽  
Chronic Comorbidities

ObjectiveTo determine the incidence of chronic comorbidities among children with type 1 diabetes (T1D) and to compare incidences with a group of children without diabetes.DesignPopulation-based cohort study.SettingDutch PHARMO database (1998–2010).PatientsAll patients (<19 years old) with T1D between 1999 and 2009 (T1D cohort) and a group of age- and sex-matched (ratio: 1–4) children without diabetes (reference cohort).Main outcome measureThe incidence of nine common chronic comorbidities was assessed on the basis that they were treated pharmacologically and/or resulted in hospital admission. Cox proportional hazard analysis was used to estimate the strength of the association between T1D and comorbidities, expressed as HRs and 95% CIs.ResultsA total of 915 patients with T1D and 3590 children in the reference cohort (51% boys, mean age of 10.1 (SD 4.5) years) were included. T1D was associated with an increased risk (HR; 95% CI) of hospitalisation for any comorbidity (3.7; 2.5 to 5.5), thyroid disease (14.2; 6.7 to 31.0), non-infectious enteritis and colitis (5.9; 3.0 to 11.5), cardiovascular disorders (3.1; 2.3 to 4.2), mental disorders (2.0; 1.4 to 3.1), epilepsy (2.0; 1.1 to 3.7) and (obstructive) pulmonary disease (1.5; 1.2 to 2.0). There was no significant difference in the incidences of other comorbidities (malignant disorders, anaemia and migraine) between the two cohorts.ConclusionsOur longitudinal study showed that incidences of six chronic diseases were significantly higher in T1D children during the early years of developing this disease compared with the reference children.

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