scholarly journals Endoplasmic Reticulum Stress-Induced Apoptosis Is Partly Mediated by Reduced Insulin Signaling Through Phosphatidylinositol 3-Kinase/Akt and Increased Glycogen Synthase Kinase-3  in Mouse Insulinoma Cells

Diabetes ◽  
2005 ◽  
Vol 54 (4) ◽  
pp. 968-975 ◽  
Author(s):  
S. Srinivasan ◽  
M. Ohsugi ◽  
Z. Liu ◽  
S. Fatrai ◽  
E. Bernal-Mizrachi ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Insulin Signaling ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Phosphatidylinositol 3 Kinase ◽  
Induced Apoptosis ◽  
Insulinoma Cells ◽  
Phosphatidylinositol 3

scholarly journals Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Liang Luo ◽  
Tangfeng Lv ◽  
Qian Wang ◽  
Ting Zhang ◽  
Xiaoling Gu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protein C ◽  
Glycogen Synthase ◽  
Umbilical Vein ◽  
Activated Protein C ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and glycogen synthase kinase-3βand inhibited apoptosis in human umbilical vein endothelial cells induced by lipopolysaccharide. Calcium inhibition did not alter the antiapoptotic effect of activated protein C. The antiapoptotic efficiency of activated protein C was reduced in human umbilical vein endothelial cells following treatment with glycogen synthase kinase-3β-siRNA. In summary, activated protein C induced endoplasmic reticulum stress and attenuated lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis mediated by glycogen synthase kinase-3β.

scholarly journals Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci

2010 ◽  
Vol 285 (53) ◽  
pp. 41337-41347 ◽  
Author(s):  
Anthony P. Popkie ◽  
Leigh C. Zeidner ◽  
Ashley M. Albrecht ◽  
Anthony D'Ippolito ◽  
Sigrid Eckardt ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Pi3k Signaling ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3
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