Impact of Diabetes on Long-Term Survival After Acute Myocardial Infarction: Comparability of risk with prior myocardial infarction

Diabetes Care ◽  
2001 ◽  
Vol 24 (8) ◽  
pp. 1422-1427 ◽  
Author(s):  
K. J. Mukamal ◽  
R. W. Nesto ◽  
M. C. Cohen ◽  
J. E. Muller ◽  
M. Maclure ◽  
...  
Heart ◽  
2021 ◽  
Vol 107 (5) ◽  
pp. 389-395
Author(s):  
Jianhua Wu ◽  
Alistair S Hall ◽  
Chris P Gale

AimsACE inhibition reduces mortality and morbidity in patients with heart failure after acute myocardial infarction (AMI). However, there are limited randomised data about the long-term survival benefits of ACE inhibition in this population.MethodsIn 1993, the Acute Infarction Ramipril Efficacy (AIRE) study randomly allocated patients with AMI and clinical heart failure to ramipril or placebo. The duration of masked trial therapy in the UK cohort (603 patients, mean age=64.7 years, 455 male patients) was 12.4 and 13.4 months for ramipril (n=302) and placebo (n=301), respectively. We estimated life expectancy and extensions of life (difference in median survival times) according to duration of follow-up (range 0–29.6 years).ResultsBy 9 April 2019, death from all causes occurred in 266 (88.4%) patients in placebo arm and 275 (91.1%) patients in ramipril arm. The extension of life between ramipril and placebo groups was 14.5 months (95% CI 13.2 to 15.8). Ramipril increased life expectancy more for patients with than without diabetes (life expectancy difference 32.1 vs 5.0 months), previous AMI (20.1 vs 4.9 months), previous heart failure (19.5 vs 4.9 months), hypertension (16.6 vs 8.3 months), angina (16.2 vs 5.0 months) and age >65 years (11.3 vs 5.7 months). Given potential treatment switching, the true absolute treatment effect could be underestimated by 28%.ConclusionFor patients with clinically defined heart failure following AMI, ramipril results in a sustained survival benefit, and is associated with an extension of life of up to 14.5 months for, on average, 13 months treatment duration.


1999 ◽  
Vol 29 (1) ◽  
pp. 14 ◽  
Author(s):  
Seok-Yeon Kim ◽  
Joo-Yong Han ◽  
Yong-Jin Kim ◽  
Ji-Dong Sung ◽  
In-Ho Chae ◽  
...  

2020 ◽  
Vol 133 (1) ◽  
pp. 100-107 ◽  
Author(s):  
Shlomit Brandis Kepler ◽  
Tal Hasin ◽  
Yael Benyamini ◽  
Uri Goldbourt ◽  
Yariv Gerber

1987 ◽  
Vol 316 (22) ◽  
pp. 1353-1359 ◽  
Author(s):  
Orlando Gomez-Marin ◽  
Aaron R. Folsom ◽  
Thomas E. Kottke ◽  
Shu-Chen H. Wu ◽  
David R. Jacobs ◽  
...  

Circulation ◽  
2004 ◽  
Vol 109 (14) ◽  
pp. 1704-1706 ◽  
Author(s):  
David Antoniucci ◽  
Angela Migliorini ◽  
Guido Parodi ◽  
Renato Valenti ◽  
Alfredo Rodriguez ◽  
...  

Resuscitation ◽  
2016 ◽  
Vol 106 ◽  
pp. e23-e24
Author(s):  
Simone Savastano ◽  
Gianmarco Iannopollo ◽  
Marco Ferlini ◽  
Gabriele Crimi ◽  
Alessandra Repetto ◽  
...  

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