scholarly journals Effect of Glimepiride on Serum Adiponectin Level in Subjects With Type 2 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (7) ◽  
pp. 2215-2216 ◽  
Author(s):  
S. Nagasaka ◽  
A. Taniguchi ◽  
Y. Aiso ◽  
T. Yatagai ◽  
T. Nakamura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level

scholarly journals Association of Serum Adiponectin with Intima Media Thickness of Dorsalis Pedis Artery and Macroangiopathy in Type 2 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Tao Chen ◽  
Mei Tu ◽  
Lihua Huang ◽  
Youping Zheng
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Adiponectin Level ◽  
Intima Media Thickness ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Diabetic Macroangiopathy ◽  
Dorsalis Pedis Artery ◽  
Traditional Risk Factors

Objective. To investigate the association of the serum adiponectin level with the intima media thickness of the dorsalis pedis artery (D-IMT) and macroangiopathy in type 2 diabetes (T2DM). Methods. We recruited 173 patients with T2DM, of whom 83 had macroangiopathy (MA group) and 90 did not have macroangiopathy (NM group), and 40 normal control subjects (NC group). We measured D-IMT using color B-mode Doppler ultrasonography. Serum adiponectin, blood glucose, lipids, and other clinical characteristics were analyzed. Participants were divided into three subgroups according to serum adiponectin level (high, moderate, and low). Results. Compared with the NM and NC groups, serum adiponectin levels were significantly decreased in the MA group after adjusting for sex and body mass index. Compared with the NM and NC groups, D-IMT was significantly increased in the MA group. Compared with the moderate- and high-adiponectin subgroups, D-IMT was significantly increased in the low-adiponectin subgroup. The prevalence of diabetic macroangiopathy increased gradually with decreasing adiponectin levels. After controlling for age, sex, smoking, and alcohol drinking, partial correlation analysis showed that adiponectin was negatively correlated with D-IMT. Elevated serum adiponectin was independently associated with a decreased risk for diabetic macroangiopathy by logistic regression analysis. Multiple linear regression analysis revealed that adiponectin was an independent factor of D-IMT. In receiver operating characteristic analyses, the area under the curve for traditional risk factors plus adiponectin for prediction of macroangiopathy was 0.984, while that of traditional risk factors alone was 0.972. Conclusions. Adiponectin is lower in patients with T2DM with macroangiopathy. We suggest that D-IMT could represent a noninvasive indicator of diabetic macroangiopathy. Decrease of adiponectin as an independent risk factor for both macroangiopathy and D-IMT among Chinese patients with T2DM suggests that adiponectin might have clinical utility in the prediction of diabetic macroangiopathy. This clinical trial is registered in the “Chinese Clinical Trial Registry.” The registration number is ChiCTR-ROC-17011731.

scholarly journals Type 2 Diabetes Mellitus is Associated with Lower Serum Adiponectin Level in Bangladeshi Population

2015 ◽  
Vol 6 (1) ◽  
pp. 10-13
Author(s):  
Sohely Nazneen Eva ◽  
Rahelee Zinnat ◽  
Golam Morshed Molla ◽  
Muneera Zahir ◽  
Fatema Akter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Serum Adiponectin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Adiponectin Level ◽  
Lower Serum ◽  
Control Subjects

Background: The physiological role of adiponectin is not yet fully clear, but it is now generally accepted that it has a protective role against the development of lifestyle disorders, related to insulin resistance and atherosclerosis. Insulin resistance is one of the basic defects of type 2 diabetes (T2DM) and adiponectin is inversely associated with T2DM. As serum adiponectin level has not yet been investigated in Bangladeshi T2DM subjects,so that the present study has been under taken to find out the association of T2DM with serum adiponectin level in Bangladeshi population.Methodology: In this observational case control study, sixty six (66) T2DM subjects, seventy four (74) healthy control subjects were included. Diabetes was diagnosed and classified as per WHO criteria. Serum Adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence-based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA IR) were assayed by homeostasis model assessment method.Results: The study subjects were BMI matched. BMI of the Control subjects and T2DM subjects (Mean±SD) were 25.02±3.55 and 25.85±3.62. Age (year) of the Control subjects and T2DM subjects (Mean±SD) were 42.46±9.24 and 48.49±8.09. Median (range) fasting serum insulin in the control and T2DM was 14.68 (1.86-45.92) and 18.09 (4.10-42.78) respectively which was not statistically significant (p=0.214). Median (range) HOMA%B values in the control and T2DM subjects was 160.10(33.40-493.40) and 100.45(17.70-349.30). Median HOMA%B in the T2DM group was significantly lower compared to the control (p=0.0001). Median (range) HOMA%S values in the control and T2DM subjects was 44.20(9.80- 339.40) and 32.80(14.30-154.70) respectively. Median HOMA%S in the T2DM group was significantly lower compared to the control (p=0.036). Median (range) serum adiponectin (?g/ml) of the control and T2DM subjects was 8.70 (0.76-15.96) and 6.19 (1.13-22.37). Serum adiponectin was significantly lower in T2DM compared to the control (p=0.0001).Conclusions: From this study it may be concluded that, T2DM subjects have both insulin secretory defects and insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Anwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 10-13

scholarly journals Type 2 diabetes mellitus is associated with lower serum adiponectin level in Bangladeshi population

Mediscope ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 16-21
Author(s):  
SN Eva ◽  
GM Mollah ◽  
DK Sunyal ◽  
R Zinnat
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Lower Serum ◽  
Control Subjects ◽  
Bangladeshi Population

The  aim  of  the  observational  case  control  study  was  to  find  out  the  association  of  type  2  diabetes  mellitus  (T2DM)  with  serum  adiponectin  level  in  Bangladeshi  population.  This  was  conducted  in  the  Biomedical  Research  Group,  Research  Division,  Bangladesh  Institute  of  Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka,  Bangladesh.  Sixty six T2DM subjects and seventy four healthy control subjects were included.  Diabetes  was  diagnosed  and  classified  as  per  World  Health  Organization  criteria.  Serum  adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum  glucose  was  measured  by  glucose-oxidase  method;  serum  insulin  was  measured  by  chemiluminescence- based ELISA technique. The insulin secretory capacity (HOMA%B), insulin  sensitivity  (HOMA%S)  &  insulin  resistance  (HOMA-IR)  were  assayed  by  homeostasis  model  assessment method. Statistical analysis was performed using SPSS Windows version 11.5. The  median  (range)  fasting  serum  insulin  of  control  and T2DM subjects  were  14.7  (1.9-45.9)  and  18.1 (4.1-42.8), respectively. The median (range) serum adiponectin (?g/ml) of the control and  T2DM  subjects  were  8.7  (0.8-16.0)  and  6.2  (1.1-22.4).  The  serum  adiponectin  of  T2DM  was  significantly lower than the control subjects (p < 0.001). The median (range) HOMA%B values  of control and T2DM subjects were 160.1 (33.4-493.4) and 100.5 (17.7-349.3), respectively. The  median  HOMA%B  of  T2DM  subjects  was  significantly  lower  than  the  control  subjects  (p  <  0.001).  The  median  (range)  HOMA%S  values  of  control  and  T2DM  subjects  were  44.2  (9.8-339.4)  and  32.8  (14.3-154.7),  respectively.  The  median  HOMA%S  of  T2DM  group  was  significantly lower than the control subjects (p < 0.05). The median (range) HOMA-IR of control  and T2DM subjects were 3.5 (0.5-11.4) and 5.8 (1.0-28.3), respectively. The median HOMA-IR  of T2DM subjects was significantly higher than the control subjects (p < 0.001). The results of  the  study  suggest  that  T2DM  subjects  have  both  insulin  secretory  defects,  insulin  resistance  and associated with lower serum adiponectin level in Bangladeshi population.Mediscope Vol. 2, No. 2: July 2015, Pages 16-21

Low serum adiponectin level as a predictor of impaired glucose regulation and type 2 diabetes mellitus in a middle-aged Finnish population

Metabolism ◽  
2008 ◽  
Vol 57 (8) ◽  
pp. 1130-1134 ◽  
Author(s):  
Kirsti Jalovaara ◽  
Merja Santaniemi ◽  
Markku Timonen ◽  
Jari Jokelainen ◽  
Y. Antero Kesäniemi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adiponectin Level ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Finnish Population ◽  
Serum Adiponectin Level ◽  
Low Serum

Glimepiride and Serum Adiponectin Level in Type 2 Diabetic Subjects: Response to Yoshioka, Yoshida, and Yoshikawa

Diabetes Care ◽  
2003 ◽  
Vol 26 (12) ◽  
pp. 3361-3361 ◽  
Author(s):  
S. Nagasaka ◽  
A. Taniguchi ◽  
Y. Aiso ◽  
T. Yatagai ◽  
T. Nakamura ◽  
...  
Keyword(s):  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Type 2 Diabetic

scholarly journals Association of Serum Vaspin and Adiponectin Levels with Renal Function in Patients with or without Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Meiyu Yan ◽  
Bin Su ◽  
Wenhui Peng ◽  
Liang Li ◽  
Hailing Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Insufficiency ◽  
Filtration Rate ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Diabetic Patients ◽  
Serum Adiponectin Level ◽  
Significant Difference ◽  
Antidiabetic Effects

Vaspin and adiponectin are two adipocytokines with antidiabetic effects. Some studies reported that levels of adiponectin and vaspin were correlated with decreased glomerular filtration rate (FGR) and increased albuminuria. We therefore evaluated the vaspin and adiponectin levels in renal insufficiency (RI) patients with or without T2DM. Serum vaspin, adiponectin levels were measured in 416 subjects with or without T2DM. Analysis was made between groups divided by these subjects presence or absence of RI. We found that serum adiponectin level was significantly higher in nondiabetic patients with RI than in nondiabetic subjects without RI; however, there were no statistical differences between the diabetic patients with RI and without RI. In all the subjects, the serum adiponectin level was also higher in 50 individuals with RI than that in 366 subjects without RI. The serum vaspin levels showed no significant differences between the diabetic patients or nondiabetics subjects with RI and without RI. Contrary to adiponectin, the serum vaspin level was lower in 169 patients with T2DM than in 247 individuals without T2DM. Our data suggested that both of T2DM and renal insufficiency were correlated with the serum level of adiponectin. However, the serum vaspin levels showed no significant difference between the individuals with renal insufficiency and without renal insufficiency.

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