scholarly journals Noninvasive Angiography and Assessment of Left Ventricular Function Using Multislice Computed Tomography in Patients With Type 2 Diabetes

Diabetes Care ◽  
2004 ◽  
Vol 27 (12) ◽  
pp. 2905-2910 ◽  
Author(s):  
J. D. Schuijf ◽  
J. J. Bax ◽  
J. W. Jukema ◽  
H. J. Lamb ◽  
H. W. Vliegen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Type 2 Diabetes ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Multislice Computed Tomography ◽  
Left Ventricular

Effects of reduced coronary flow reserve on left ventricular function in type 2 diabetes

2008 ◽  
Vol 82 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Osamu Yonaha ◽  
Tatsuaki Matsubara ◽  
Keiko Naruse ◽  
Hideki Ishii ◽  
Toyoaki Murohara ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Left Ventricular ◽  
Flow Reserve

scholarly journals Cardioprotective Effect of Decorin in Type 2 Diabetes

2020 ◽  
Vol 11 ◽  
Author(s):  
Fuqiong Chen ◽  
Jinsheng Lai ◽  
Yanfang Zhu ◽  
Mengying He ◽  
Huiying Hou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Diabetic Cardiomyopathy ◽  
Treated Group ◽  
Left Ventricular ◽  
Control Group ◽  
Lv Function ◽  
Cardiac Inflammation

Cardiomyopathy is the leading cause of increased mortality in diabetes. In the present study, we investigated the effects of decorin (DCN) gene therapy on left ventricular function, cardiac inflammation and fibrosis in type 2 diabetes. Type 2 diabetes was induced in male Wistar rats by high fat diet (HFD, 60% of calories as fat) and STZ (20 mg/kg, intraperitoneal). Diabetic rats were divided into (n=6 for each group) the control group, the GFP-treated group and the DCN-treated group, received intravenous injection of saline solution, recombinant adeno-associated viral (rAAV)-GFP, and rAAV-DCN, respectively. We evaluated cardiac inflammation, fibrosis, left ventricular function at 6 months after gene delivery. Results turned out that rAAV-DCN treatment attenuated diabetic cardiomyopathy with improved LV function compared with control animals, which might be related to the reduced cardiac inflammation and fibrosis. These protective effects were associated with TGFβ1 pathway (ERK1/2 and smad-2) and NF-κB pathway, which may due to the decreased activation level of IGF-IR, increased expression of PKC-α and Hsp70. In conclusion, our results show that rAAV-mediated DCN therapy may be beneficial in the treatment of Diabetic Cardiomyopathy.

Myocardial Steatosis and Left Ventricular Function in Asymptomatic Patients with Type 2 Diabetes Mellitus

2009 ◽  
Vol 18 ◽  
pp. S41
Author(s):  
Arnold C.T. Ng ◽  
Victoria Delgado ◽  
Rutger W. van der Meer ◽  
Matteo Bertini ◽  
Gaetano Nucifora ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Asymptomatic Patients ◽  
Myocardial Steatosis
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