scholarly journals Efficacy of Dupilumab for Atopic Dermatitis According to Clinical Course and Clinical Findings: A Multicentre Retrospective Study

2021 ◽  
Author(s):  
Takeshi Nakahara ◽  
Makiko Kido-Nakahara ◽  
Daisuke Onozuka ◽  
Sawako Sakai ◽  
Tomoko Hirose ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Retrospective Study ◽  
Short Communication ◽  
Clinical Course ◽  
Clinical Findings ◽  
Multicentre Retrospective Study

Abstract is missing (Short communication)

scholarly journals Clinical course and treatment efficacy of COVID‐19 near Hubei Province, China: A multicentre, retrospective study

2020 ◽  
Vol 67 (6) ◽  
pp. 2971-2982 ◽  
Author(s):  
Qing‐Lei Zeng ◽  
Guang‐Ming Li ◽  
Fanpu Ji ◽  
Shu‐Huan Ma ◽  
Guo‐Fan Zhang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Treatment Efficacy ◽  
Clinical Course ◽  
Hubei Province ◽  
Multicentre Retrospective Study

scholarly journals Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Stine Grønseth ◽  
Tormod Rogne ◽  
Raisa Hannula ◽  
Bjørn Olav Åsvold ◽  
Jan Egil Afset ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Fold Increase ◽  
Epidemiological Data ◽  
Opportunistic Pathogen ◽  
Incidence Rates ◽  
Clinical Findings ◽  
Pneumocystis Jirovecii ◽  
Common Denominator ◽  
Study Population ◽  
Cardinal Symptoms

Abstract Background Pneumocystis pneumonia (PCP) severely menaces modern chemotherapy and immunosuppression. Detailed description of the epidemiology of Pneumocystis jirovecii today is needed to identify candidates for PCP-prophylaxis. Methods We performed a 12-year retrospective study of patients with P. jirovecii detected by polymerase chain reaction in Central Norway. In total, 297 patients were included. Comprehensive biological, clinical and epidemiological data were abstracted from patients’ medical records. Regional incidence rates and testing trends were also assessed. Results From 2007 to 2017 we found a 3.3-fold increase in testing for P. jirovecii accompanied by a 1.8-fold increase in positive results. Simultaneously, regional incidence rates doubled from 5.0 cases per 100,000 person years to 10.8. A majority of the study population had predisposing conditions other than human immunodeficiency virus (HIV). Hematological (36.0%) and solid cancers (25.3%) dominated. Preceding corticosteroids were a common denominator for 72.1%. Most patients (74.4%) presented with at least two cardinal symptoms; cough, dyspnea or fever. Main clinical findings were hypoxia, cytopenias and radiological features consistent with PCP. A total of 88 (29.6%) patients required intensive care and 121 (40.7%) suffered at least one complication. In-hospital mortality was 21.5%. Three patients (1.0%) had received prophylaxis. Conclusions P. jirovecii is re-emerging; likely due to increasing immunosuppressants use. This opportunistic pathogen threatens the life of heterogenous non-HIV immunosuppressed populations currently at growth. Corticosteroids seem to be a major risk factor. A strategy to increase prophylaxis is called for.

scholarly journals Fatal Subacute Hepatic Failure in a Patient with AA-Type Amyloidosis: Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Ibrahim Altraif ◽  
Fayaz A. Handoo ◽  
Khaled O. Alsaad ◽  
Adel Gublan
Keyword(s):  
Alkaline Phosphatase ◽  
Case Report ◽  
Hepatic Failure ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Clinical Findings ◽  
Systemic Amyloidosis ◽  
Hepatic Involvement ◽  
Reactive Amyloidosis ◽  
Hepatic Amyloidosis

Although systemic amyloidosis of amyloid-associated protein (AA) type (secondary or reactive amyloidosis) frequently involves the liver, it rarely causes clinically apparent liver disease. Mild elevation of alkaline phosphatase and hepatomegaly are the most common biochemical and clinical findings, respectively. We report a case of systemic amyloidosis of AA type, which clinically presented as subacute hepatic failure and resulted in a fatal clinical course in a 69-year-old man. To the best of our knowledge, this is the fifth case of hepatic amyloidosis of AA type that clinically presented as fatal subacute hepatic failure, an unusual clinical presentation for hepatic involvement by systemic AA-type amyloid.

scholarly journals Two-year efficacy, safety, and drug survival of dupilumab for atopic dermatitis: A real-world Canadian multicenter retrospective study

2021 ◽  
Vol 4 ◽  
pp. 67-69
Author(s):  
Jorge R. Georgakopoulos ◽  
Tina Felfeli ◽  
Aaron M. Drucker ◽  
Christine E. Jo ◽  
Vincent Piguet ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Retrospective Study ◽  
Real World ◽  
Drug Survival

Efficacy of factor IX Grifols® in surgery: experience of an international multicentre retrospective study

Haemophilia ◽  
2012 ◽  
Vol 18 (5) ◽  
pp. e372-e373 ◽  
Author(s):  
R. Pérez-Garrido ◽  
N. Alonso ◽  
V. Jiménez-Yuste ◽  
S. Haya ◽  
P. Zúñiga ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Factor Ix ◽  
Multicentre Retrospective Study
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