COVID-19 pneumonia in active pulmonary tuberculosis patients: a series of cases

Author(s):  
Ruiqi SHI ◽  
Qiuxia DUAN ◽  
Weihao DONG ◽  
Yong GUO ◽  
Shengwei XU
PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259006
Author(s):  
Ashutosh Nath Aggarwal ◽  
Ritesh Agarwal ◽  
Sahajal Dhooria ◽  
Kuruswamy Thurai Prasad ◽  
Inderpaul Singh Sehgal ◽  
...  

Objective The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. Methods We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. Results We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. Conclusion Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.


2019 ◽  
Vol 65 (5) ◽  
pp. 390-398 ◽  
Author(s):  
Qiuzhen WANG ◽  
Aiguo MA ◽  
Tianlin GAO ◽  
Yufeng LIU ◽  
Lisheng REN ◽  
...  

2018 ◽  
Vol 06 (09) ◽  
pp. E1103-E1108 ◽  
Author(s):  
Miwako Saitou ◽  
Daiki Nemoto ◽  
Kenichi Utano ◽  
Tomoko Suzuki ◽  
Alan Kawarai Lefor ◽  
...  

Abstract Background and study aims Mycobacterium tuberculosis is often detected in the feces of patients with active pulmonary tuberculosis. However, no study has examined the small intestine using small bowel capsule endoscopy (SBCE). This study aimed to investigate intestinal abnormalities in patients with active pulmonary tuberculosis. Patients and methods SBCE was performed in sputum/feces smear-positive pulmonary tuberculosis patients. From December 2013 to November 2016, 15 patients were enrolled from a dedicated tuberculous ward. The primary outcome was intestinal abnormalities identified by SBCE. Results Fourteen patients (median age 81 years, range 29 – 91; 3 female) underwent SBCE to the terminal ileum. The video was not recorded for one patient who was excluded from the analysis. Intestinal lesions, including 5 annular ulcers in 4 patients, were observed in 64 % (9/14). In subgroup analysis, prevalence tended to be higher in patients undergoing SBCE within 1 month of anti-tuberculous therapy (P = 0.051). Distribution of small intestinal lesions tended to be distal. Four of five annular ulcers were located close to the ileocecal valve. Conclusion Prevalence of intestinal lesions in patients with pulmonary tuberculosis is higher than expected before (UMIN 000017292)


2017 ◽  
Vol 24 (34) ◽  
pp. 26513-26520 ◽  
Author(s):  
Zainab Manzoor Memon ◽  
Erkan Yilmaz ◽  
Afsheen Mushtaque Shah ◽  
Ugur Sahin ◽  
Tasneem Gul Kazi ◽  
...  

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