Measuring the horizontal and vertical growth rates of superficial spreading melanoma: a pilot study with sequential digital dermoscopy

2021 ◽  
Vol 156 (4) ◽  
Author(s):  
Vito INGORDO ◽  
Luca FECI ◽  
Simone CAZZANIGA ◽  
Luigi NALDI ◽  
Irene INGORDO ◽  
...  
Keyword(s):  
Pilot Study ◽  
Growth Rates ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
Vertical Growth ◽  
Digital Dermoscopy

Superficial Spreading Melanoma with a Nodular Area: Antigenic Phenotype of the Radial and Vertical Growth Areas

1989 ◽  
Vol 75 (1) ◽  
pp. 8-11 ◽  
Author(s):  
Laura Brogelli ◽  
Silvia Moretti ◽  
Benvenuto Giannotti
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Progression ◽  
Statistical Significance ◽  
Primary Melanoma ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
Phenotypic Differences ◽  
Vertical Growth ◽  
Hla Dr ◽  
Antigenic Phenotype

We investigated antigenic features associated with different tumor progression steps in primary melanoma, interpreted as different patterns of growth (radial and vertical) in the same and in different lesions. Thirty-eight primary melanomas were examined: 18 superficial spreading malanomas, 13 superficial spreading melanomas with a nodular area and 7 nodular melanomas. 225.28,763.74, CL.203, VF19LL209, VF19LL217, Q5.13, W6.32 and anti-HLA-DR monoclonal antibodies were used. Phenotypic differences between radial and vertical growth areas were observed but no statistical significance could be found.

scholarly journals Evolution of superficial spreading melanoma to resemble desmoplastic melanoma: case report

2021 ◽  
Author(s):  
Martin G. Cook ◽  
Barry W. E. M. Powell ◽  
Megan E. Grant ◽  
Adele C. Green
Keyword(s):  
Case Report ◽  
Clinical Management ◽  
Unusual Case ◽  
Primary Site ◽  
Mixed Tumor ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
Desmoplastic Melanoma ◽  
Mixed Features ◽  
Melanoma Case

AbstractDesmoplastic melanoma commonly occurs on the head and neck in a pure form, but occasionally, it occurs in a mixed tumor with another type, usually superficial spreading melanoma (SSM), and rarely as a metastasis from a primary SSM. We report here a primary SSM on the leg of a 32-year-old male which metastasised to lymph nodes, and 10 years later recurred at the primary site initially with mixed features but evolving to resemble a uniformly desmoplastic, deeply invasive melanoma. This unusual case has implications for clinical management and is additionally notable for its reversal in behavior, from metastatic to local infiltrative type, correlating with the change in morphology.

scholarly journals Cutaneous Melanomas Arising during Childhood: An Overview of the Main Entities

2021 ◽  
Vol 8 (3) ◽  
pp. 301-314
Author(s):  
Arnaud de la Fouchardière ◽  
Felix Boivin ◽  
Heather C. Etchevers ◽  
Nicolas Macagno
Keyword(s):  
Lymph Node ◽  
Regional Lymph Node ◽  
Germline Mutations ◽  
Epithelioid Cells ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
Cancer Predisposition Syndrome ◽  
Specific Morphology ◽  
Genetic Features ◽  
Molecular Assessment

Cutaneous melanomas are exceptional in children and represent a variety of clinical situations, each with a different prognosis. In congenital nevi, the risk of transformation is correlated with the size of the nevus. The most frequent type is lateral transformation, extremely rare before puberty, reminiscent of a superficial spreading melanoma (SSM) ex-nevus. Deep nodular transformation is much rarer, can occur before puberty, and must be distinguished from benign proliferative nodules. Superficial spreading melanoma can also arise within small nevi, which were not visible at birth, usually after puberty, and can reveal a cancer predisposition syndrome (CDKN2A or CDK4 germline mutations). Prognosis is correlated with classical histoprognostic features (mainly Breslow thickness). Spitz tumors are frequent in adolescents and encompass benign (Spitz nevus), intermediate (atypical Spitz tumor), and malignant forms (malignant Spitz tumor). The whole spectrum is characterized by specific morphology with spindled and epithelioid cells, genetic features, and an overall favorable outcome even if a regional lymph node is involved. Nevoid melanomas are rare and difficult to diagnose clinically and histologically. They can arise in late adolescence. Their prognosis is currently not very well ascertained. A small group of melanomas remains unclassified after histological and molecular assessment.

NATURAL HISTORY OF A SUPERFICIAL SPREADING MELANOMA

1993 ◽  
Vol 32 (4) ◽  
pp. 293-296 ◽  
Author(s):  
CARLIN MCLAUGHLIN ◽  
HENRY C. MAGUIRE ◽  
MICHAEL J. MASTRANGELO
Keyword(s):  
Natural History ◽  
Superficial Spreading ◽  
Superficial Spreading Melanoma ◽  
History Of
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