scholarly journals Serum 25-Hydroxyvitamin D Levels of Apparently Healthy Nigerian Children Aged 1-24 Months

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
FD Akeredolu ◽  
RM Akuse ◽  
SM Mado ◽  
R Yusuf
Keyword(s):  
Hydroxyvitamin D ◽  
Nigerian Children ◽  
25 Hydroxyvitamin D ◽  
Apparently Healthy

scholarly journals Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Bankole Peter Kuti ◽  
Alex Ifeoluwa Akinwumi ◽  
Demilade Kehinde Kuti ◽  
Kazeem Olanrewaju Amoo
Keyword(s):  
Vitamin D ◽  
Total Antioxidant Capacity ◽  
Serum Vitamin ◽  
Severe Pneumonia ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Nigerian Children ◽  
Total Antioxidant ◽  
25 Hydroxyvitamin D

Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children.

scholarly journals Serum 25-Hydroxyvitamin D and Insulin Resistance in Apparently Healthy Adolescents

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103108 ◽  
Author(s):  
Dong Phil Choi ◽  
Sun Min Oh ◽  
Ju-Mi Lee ◽  
Hye Min Cho ◽  
Won Joon Lee ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Apparently Healthy

Height, Whole Body Surface Area, Gender, Working Outdoors, and Sunbathing in Previous Summer are Important Determinants of Serum 25-hydroxyvitamin D Levels

2011 ◽  
Vol 120 (01) ◽  
pp. 14-22 ◽  
Author(s):  
K. Pazaitou-Panayiotou ◽  
P. Papapetrou ◽  
A. Chrisoulidou ◽  
S. Konstantinidou ◽  
E. Doumala ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Skin Color ◽  
Whole Body ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Obese Subjects ◽  
Previous Summer ◽  
Apparently Healthy

AbstractTo investigate if serum 25-hydroxyvitamin D (25(OH)D) is related to the whole Body Surface Area (BSA), and to several other anthropometric and environmental factors.Serum 25(OH)D was determined in 489 apparently healthy subjects (346 women and 143 men, mean age 43.9 years) in April and May. From all subjects the following data were available: height, body weight, waist to hip ratio, BSA, BMI, environment of work (indoors vs. outdoors), habit of regularly sunbathing during previous summer(s), fear of sun, dwelling in city or village, and skin color.Approximately 43% of the participants had serum 25(OH)D levels between 10 and 20 ng/ml, 44% had values between 20.1 and 30 ng/ml, whereas about 5% had values below 10 ng/ml and only 9% had values above 30 ng/ml. There was a significant positive relationship between 25(OH)D, height and BSA, which was more pronounced for BSA in obese subjects even after adjustment for work outdoors and sunbathing during previous summer(s). Outdoor workers and sunbathers had higher 25(OH)D compared to indoor workers and non-sunbathers respectively. Men when compared to women had higher 25(OH)D regardless of BMI and this difference was apparently due to the fact that men were taller, had greater BSA, and worked more often outdoors.Height, whole BSA, gender, working outdoors and sunbathing in previous summer(s) proved to be significant determinants of serum 25(OH)D. Vitamin D status is higher in taller individuals with greater BSA, and in men when compared to women.

scholarly journals Vitamin D status of apparently healthy schoolgirls from two different socioeconomic strata in Delhi: relation to nutrition and lifestyle

2007 ◽  
Vol 99 (4) ◽  
pp. 876-882 ◽  
Author(s):  
Seema Puri ◽  
Raman K. Marwaha ◽  
Neha Agarwal ◽  
Nikhil Tandon ◽  
Rashmi Agarwal ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Hypovitaminosis D ◽  
Childhood And Adolescence ◽  
Vitamin D Status ◽  
Indian Children ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Socioeconomic Strata ◽  
Apparently Healthy

Forty to fifty per cent of skeletal mass, accumulated during childhood and adolescence, is influenced by sunlight exposure, physical activity, lifestyle, endocrine status, nutrition and gender. In view of scarce data on association of nutrition and lifestyle with hypovitaminosis D in Indian children and adolescents, an in-depth study on 3127 apparently healthy Delhi schoolgirls (6–18 years) from the lower (LSES, n 1477) and upper socioeconomic strata (USES, n 1650) was carried out. These girls were subjected to anthropometry and clinical examination for hypovitaminosis D. Girls randomly selected from the two strata (LSES, n 193; USES, n 211) underwent detailed lifestyle, dietary, biochemical and hormonal assessment. Clinical vitamin D deficiency was noted in 11·5 % girls (12·4 % LSES, 10·7 % USES). USES girls had significantly higher BMI than LSES counterparts. Prevalence of biochemical hypovitaminosis D (serum 25-hydroxyvitamin D < 50 nmol/l) was seen in 90·8 % of girls (89·6 % LSES, 91·9 % USES, NS). Mean intake of energy, protein, fat, Ca, vitamin D and milk/milk products was significantly higher in USES than LSES girls. Conversely, carbohydrate, fibre, phytate and cereal intakes were higher in LSES than USES girls. Physical activity and time spent outdoors was significantly higher in LSES girls (92·8 v. 64 %, P = 0·000). Significant correlation between serum 25-hydroxyvitamin D and estimated sun exposure (r 0·185, P = 0·001) and percentage body surface area exposed (r 0·146, P = 0·004) suggests that these lifestyle-related factors may contribute significantly to the vitamin D status of the apparently healthy schoolgirls. Hence, in the absence of vitamin D fortification of foods, diet alone appears to have an insignificant role.

Influence of serum 25-hydroxyvitamin D on the rate of pain episodes in Nigerian children with sickle cell anaemia

2017 ◽  
Vol 37 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Samuel Ademola Adegoke ◽  
Oyeku Akibu Oyelami ◽  
Adekunle Adekile ◽  
Maria Stella Figueiredo
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Hydroxyvitamin D ◽  
Nigerian Children ◽  
25 Hydroxyvitamin D

scholarly journals The establishment of serum 25-hydroxyvitamin D reference intervals in children aged 0–14 years in Zigong area, China

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Jianhong Yu ◽  
Xiaoping He ◽  
Shengwei Huang
Keyword(s):  
Age Groups ◽  
Reference Interval ◽  
Reference Intervals ◽  
Healthy Children ◽  
Hydroxyvitamin D ◽  
Significant Difference ◽  
Different Seasons ◽  
25 Hydroxyvitamin D ◽  
Apparently Healthy ◽  
Normally Distributed

Abstract Objective To establish the reference interval of serum 25-hydroxyvitamin D (25(OH)D) in apparently healthy children in Zigong, China, using an indirect method to provide a basis for proper clinical diagnosis and treatment. Methods A total of 1851 apparently healthy children of the Children’s Health Care Department in Zigong First People’s Hospital between January 2016 and December 2020 were included in the study. The Kolmogorov–Smirnov test was used to analyze the data for normality, and the non-normally distributed data were transformed into approximately normal distribution by Blom's normal rank transformation, and the transformed data were excluded from outliers by the quartile spacing method, and the data were stratified and analyzed according to sex, age, and season. The data were stratified according to sex, age, and season, and the area between the 2.5% and 97.5% percentile points was used as the reference interval. Results The serum 25(OH)D data were non-normally distributed. The data were normally distributed after Blom’s normality rank transformation, and 92 cases of outliers were excluded from the transformed data according to the interquartile spacing method. The differences in serum 25(OH)D levels between sex were not statistically significant (P > 0.05), and there was no need to establish reference intervals based on sex. There was no statistically significant difference in serum 25-hydroxyvitamin D levels between winter and spring, and also no difference between summer and autumn (P > 0.05), and the levels were lower in winter-spring than in summer-autumn. Comparison between age groups showed that there was no statistically significant difference in serum 25(OH)D levels between the < 6 months group and the 6 ~ 11 months group, and between the 6 ~ 9 years group and the 10 ~ 14 years group (P > 0.05); serum 25(OH)D levels decreased with increasing age. There was an interactive effect of season and age group on 25(OH)D levels, and the corresponding reference intervals were established according to different seasons and age groups. In summer and autumn, the reference intervals of serum 25(OH)D for < 1 year, 1 ~ 2 years, 3 ~ 5 years, and 6 ~  14 years were 39.86 ~ 151.43, 31.54 ~ 131.65, 22.05 ~ 103.75, and 15.36 ~ 85.53 ng/ml and 24.42 ~ 144.20, 31.54 ~ 131.65, 16.80 ~ 165.68, and 15.46 ~ 85.54 ng/ml in winter and spring, respectively. Conclusion Reference intervals for serum 25(OH)D in children of different seasons and ages in Zigong, China, were established to provide a reference for clinical disease diagnosis, treatment, and prognosis determination.

Serum 25-hydroxyvitamin D requirements to prevent rickets in Nigerian children on a calcium-deprived diet

2019 ◽  
Author(s):  
Tom Thacher ◽  
Christopher Sempos ◽  
Ramon Durazo-Arvizu ◽  
Craig Munns ◽  
Philip Fischer ◽  
...  
Keyword(s):  
Hydroxyvitamin D ◽  
Nigerian Children ◽  
25 Hydroxyvitamin D
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