Comparison of Nifedipine and Isoxsuprine to Cervical Length in Threatened Preterm Labor

Objective: This study aimed to determine differences in cervical length changes between administration of nifedipine and isoxsuprine. Method: Subjects of the study were pregnant women who meet the inclusion criteria (n=16). Treatments were given for 48 hours. Parameters measured was the cervical length before and after the administration of nifedipine and isoxsuprine. This study was conducted in Dr. Hasan Sadikin General Hospital from January until April 2020. Result: Less shortening of the cervical length after administration of tocolytic isoxsuprin for 48 hours compared with tocolytic nifedipine and statistically significant with p value of 0.0001 (p<0.05) using Paired T tests. Conclusion: Isoxsuprin is more effective to prevent shortening of the cervical length compared to nifedipine in cases of threatened preterm labor. Key word: Nifedipine, Isoxsuprine, cervical length, threatened preterm labor

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Sildenafil Citrate Versus Nifedipine and Dydrogesreone in Prevention of Preterm Labor with Short Cervix

Obstetrics Gynecology and Reproductive Sciences ◽

10.31579/2578-8965/009 ◽

2018 ◽

Vol 2 (1) ◽

pp. 01-05

Author(s):

Abd El-Naser Abd El-Gaber Ali ◽

Khaled M Abdallah ◽

Ahmed Abdelhamid

Keyword(s):

Pregnant Women ◽

Preterm Labor ◽

Cervical Length ◽

Sildenafil Citrate ◽

Health Concern ◽

P Value ◽

Short Cervix ◽

Group I ◽

Significant Difference ◽

Group Ii

Background: Prevention of the premature birth occurrence remains is considered one of the most tough challenges for obstetricians worldwide, mainly to avoid neonatal prematurity complications leading to short and long term morbidities additionally prematurity prevention will reduce premature neonatal mortality rates which is considered a major health concern of obstetricians, neonatologists and families. Objective: To compare and contrast the efficacy of Sildenafil citrate, Nifedipine and Dydrogesrone in prevention of premature labor in gestations with short cervix. Setting: Obstetrics & Gynecology Departments, Faculties of medicine, south Valley and Al-Azhar (Asyut) Universities, Egypt. Duration: from September 2014 to March 2018. Patients And Methds: the study was conducted on 300 pregnant women who randomly divided into three groups: Group I included 100 cases received Sildenafil citrate (Respatio tablet 20mg twice daily orally), Group II included 100 cases received Nifedipine (Epilat retard tablets 20mg twice daily orally) and Group III included 100 pregnant women received dydrogesreone 10 mg (Duphaston) twice daily orally. Results: incidence of preterm labor was (9.37, 8.51 and 14.28) in (Group I, Group II and Group II) respectively. Mean ± SD of cervical length at 32 weeks of gestation was mildly statistically significant among groups (p value <0.05) but no significance in neonatal outcome (p value >0.05) except birth weight which had a highly statistically significant difference (p value < 0.001). There was a highly statistically significant difference among studied groups as regard to drug side effects in (p value <0.001). Conclusion: Sildenafil citrate was as effective as Nifedipine and better than oral Dydrogesterone on myometrial relaxation and prevention of preterm birth in pregnant women who had short cervix.

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Threatened Preterm Labor: Which are become Preterm Labor?

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v8i4.1299 ◽

2020 ◽

pp. 216-222

Author(s):

Cut M. Yeni ◽

Rismawati Tambunan ◽

Hasanuddin

Keyword(s):

Pregnant Women ◽

Preterm Labor ◽

Case Control ◽

Cervical Length ◽

Wilcoxon Test ◽

Fetal Fibronectin ◽

Whitney Test ◽

Vaginal Ph ◽

Chi Squared ◽

Threatened Preterm Labor

Objective: The research was aimed to show about characteristics of subject, fetal fibronectin, vaginal pH, cervical length of women with threatened preterm labor, and which are become preterm labor? Preterm labor is occurs most often in 20 weeks gestation to less than 37 weeks gestation. This condition is concerned about Obstetric problem and associated with significant neonatal morbidity and mortality.Methods: This study used the design of case control where preterm pregnant women who become research subjects divided into two groups with threat and without the threat of pre-term labor. Fetal fibronectin , vaginal pHand cervical length than in both groups were evaluated as a risk factor for preterm labor. Mann-Whitney test , Wilcoxon test and Chi-squared test were used as statistical tests with a confidence level of 95%.Results: A total of 86 preterm pregnant women involved in this study with an average age 30 , 5 ± 6.25 (group threat) 32.16 ± 5.25 (non-threatening). Comparison of fetal fibronectin (p = 0.005), vaginal PH(p <0.001) and length of the cervix (p <0.001) between the two groups showed a significant difference. A total of 8 subjects of the 43 in the group of pregnant women with the threat pretem labor experiencing preterm labor .Conclusion: The size of a short cervical length, an increase in the pH of the vaginal secretions and increased levels of fetal fibronectin is a clinical indicator for screening during pregnancy to assess the risk of a preterm labor .Keywords: cervical length, fetal fibronectin, pretermlabor , vaginal pH of the secretions. Abstrak Tujuan: Persalinan preterm adalah persalinan yang terjadi padausia kehamilan 20 hingga kurang dari37 minggu. Kondisi inimerupakanpermasalahan yang sangat mengkhawatirkan dalam bidang kebidanan dan dikaitkan dengan morbiditas dan kematian neonatal yang signifikan. Evaluasi dan skrining terhadap berbagai faktor resiko terjadinya ancaman persalinan preterm adalah hal terpenting dalam mencegah berbagai komplikasi yang mungkin timbul.Metode: Penelitian ini menggunakan desain case control dimana wanita hamil preterm yang menjadi subjek penelitian terbagi menjadi dua yakni kelompok dengan ancaman dan tanpa ancaman persalinan preterm. Fetal fibronectin, pH sekret vagina dan panjang serviks dibandingkan diatara kedua kelompok sebagai faktor resiko ancaman persalinan preterm. Mann-Whitney test, Wilcoxon test dan Chi – squared digunakan sebagai uji statistik dengan tingkat kepercayaan 95%.Hasil: Sebanyak 86 wanita hamil preterm terlibat dalam penelitian ini dengan rerata usia 30,5 ± 6,25 (kelompok ancaman) 32,16 ± 5,25 (tanpa ancaman). Perbandingan Fetal fibronectin (p=0,005), pH sekret vagina (p<0,001) dan panjang serviks (p<0,001) antar kedua kelompok menunjukkan adanya perbedaan yang bermakna. Sebanyak 8 subjek dari 43 pada kelompok wanita hamil pretem dengan ancaman persalinan preterm yang mengalami persalinan pretermKesimpulan:Ukuran panjang serviks yang pendek, peningkatan pH sekret vagina dan peningkatan kadar fetal fibronectin merupakan indikator klinis untuk skrining selama kehamilan guna menilai resiko terjadinya persalinan pretermKata kunci: fetal fibronectin, persalinan preterm, Ph vagina, panjang cerviks

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Role of transvaginal ultrasound in predicting preterm labor in singleton pregnancies

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20180172 ◽

2018 ◽

Vol 7 (2) ◽

pp. 561

Author(s):

Mehbooba Beigh ◽

Mohammed Farooq Mir ◽

Rifat Amin ◽

Simrath Shafi

Keyword(s):

Preterm Delivery ◽

Predictive Value ◽

Preterm Labor ◽

Transvaginal Ultrasound ◽

Cervical Length ◽

Spontaneous Preterm Birth ◽

Threatened Preterm Labor ◽

Length Changes ◽

A Prospective Study

Background: Preterm delivery (PTD) is a major cause of perinatal morbidity and mortality. Objective of present study was to identify the women at risk of preterm delivery with the help of trans-vaginal ultrasound by assessing cervical length changes, funneling of lower uterine segment, cervical dilatation.Methods: A prospective study was carried out over a period of 2 years on 50 patients with 24-36 weeks of gestation who clinically presented with signs of threatened preterm labor and were subjected to transvaginal sonographic measurement of cervical length.Results: Prediction of spontaneous preterm birth at <37 weeks of gestation with cervical length to be 2.75 cm has sensitivity of 95%, specificity of 96.5%, positive predictive value of 86.36% and negative predictive value of 98.7%.Conclusions: Transvaginal ultrasonography is the reliable, reproducible and objective method to assess cervix and to predict the risk of preterm delivery.

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The effect of pregnancy exercise on the anxiety level of the third trimester of pregnant woman in the Kecamatan Sukawati

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20205288 ◽

2020 ◽

Vol 8 (12) ◽

pp. 4197

Author(s):

Ayuk Widiani N. N. ◽

Noviani N. W.

Keyword(s):

Pregnant Women ◽

Sampling Technique ◽

Anxiety Level ◽

Bivariate Analysis ◽

P Value ◽

Inclusion Criteria ◽

Third Trimester ◽

The Third ◽

Before And After ◽

Post Test

Background: This study aims to know the effect of pregnancy exercise on the anxiety level of the third trimester of pregnant women.Methods: This type of research is analytic with a one group pre-test post-test design without control, the number of samples is 50 pregnant women who meet the inclusion criteria by using purposive sampling technique. The instrument data collection using depression anxiety and stress scale (DASS) questionnaire. Bivariate analysis using Wilcoxon test.Results: The result of the data shows p value of anxiety level of pregnant women before and after the implementation of pregnancy exercise is 0.000 (<0.05), it can be concluded that there is an effect of the implementation of pregnancy exercise on the anxiety level of pregnant women in the third trimester.Conclusions: From the result of research conducted, the effect of the implementation of pregnancy exercise on the anxiety level of pregnant women before and after of pregnant women in the third trimester.

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The value of cervical length and plasma proMMP-9 levels for the prediction of preterm delivery in pregnant women presenting with threatened preterm labor

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2005.10.022 ◽

2006 ◽

Vol 128 (1-2) ◽

pp. 108-112 ◽

Cited By ~ 9

Author(s):

Demetrios Botsis ◽

Evangelos Makrakis ◽

Vassiliki Papagianni ◽

Evangelia Kouskouni ◽

Odysseas Grigoriou ◽

...

Keyword(s):

Pregnant Women ◽

Preterm Delivery ◽

Preterm Labor ◽

Cervical Length ◽

Threatened Preterm Labor

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Predictive Accuracy of Three Dimensional Ultrasound Measurement of Fetal Adrenal Gland Volume in Preterm Labor Cases

QJM ◽

10.1093/qjmed/hcaa056.002 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

W H A Eltantawy ◽

M M N Mohyieldin ◽

A H Mohammed

Keyword(s):

Preterm Birth ◽

Adrenal Gland ◽

Pregnant Women ◽

Preterm Labor ◽

Cervical Length ◽

Fetal Fibronectin ◽

Gland Volume ◽

Significant Difference ◽

Threatened Preterm Labor ◽

Adrenal Gland Volume

Abstract Background Preterm birth is one of the major clinical problems in obstetrics and neonatology as it is associated with perinatal mortality, serious neonatal morbidity and in some cases childhood disability. It is reported that more than 80% of all neonatal mortality and morbidity is due to preterm birth. Objective In this study fetal adrenal gland volume and fetal zone measurement were used as a predictors for occurrence of labor in singleton pregnancies complicated by threatened preterm labor in comparison to cervical length and cervicovaginal fetal fibronectin. Methodology The study was carried out at Ain Shams University Maternity Hospital. The current study include 88 pregnant women who presented with symptoms or signs of threatened preterm labor (PTL). All women were subjected to full history taking, full general, abdominal, pelvic examination, in addition to ultrasound fetal biometry, measurement of cervical length, measurement of fetal fibronectin, fetal adrenal gland volume AGV and fetal zone acquisitions. Results Our results showed high statistically significant difference between the two groups of women regarding CL measurement, FZE and cAGV with P values < 0.001 suggesting that ultrasound examination of fetal adrenal gland and assessment of FZE at time of evaluation for symptoms of PTL may be clinically beneficial in predicting the occurrence of labor in pregnant women at risk of preterm labor. Conclusion Our results demonstrate that in women presenting with threatened preterm labor, cAGV and FZE measured by 3-dimensional ultrasound seem to be significant predictors of delivery within 7 days, when compared to CL and cervicovaginal fetal fibronectin.

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The value of cervical length and plasma proMMP-9 levels for the prediction of preterm delivery in pregnant women presenting with threatened preterm labor

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70079-1 ◽

2007 ◽

Vol 2007 ◽

pp. 109-110

Author(s):

L.P. Shulman

Keyword(s):

Pregnant Women ◽

Preterm Delivery ◽

Preterm Labor ◽

Cervical Length ◽

Threatened Preterm Labor

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Optimization of Imminent Labor Prediction Systems in Women with Threatened Preterm Labor Based on Electrohysterography

Sensors ◽

10.3390/s21072496 ◽

2021 ◽

Vol 21 (7) ◽

pp. 2496

Author(s):

Gema Prats-Boluda ◽

Julio Pastor-Tronch ◽

Javier Garcia-Casado ◽

Rogelio Monfort-Ortíz ◽

Alfredo Perales Marín ◽

...

Keyword(s):

Preterm Labor ◽

Cervical Length ◽

Validation Dataset ◽

Computationally Efficient ◽

K Nearest Neighbors ◽

Predictive Values ◽

Classifier Design ◽

Input Dataset ◽

Threatened Preterm Labor ◽

Learning Machine

Preterm birth is the leading cause of death in newborns and the survivors are prone to health complications. Threatened preterm labor (TPL) is the most common cause of hospitalization in the second half of pregnancy. The current methods used in clinical practice to diagnose preterm labor, the Bishop score or cervical length, have high negative predictive values but not positive ones. In this work we analyzed the performance of computationally efficient classification algorithms, based on electrohysterographic recordings (EHG), such as random forest (RF), extreme learning machine (ELM) and K-nearest neighbors (KNN) for imminent labor (<7 days) prediction in women with TPL, using the 50th or 10th–90th percentiles of temporal, spectral and nonlinear EHG parameters with and without obstetric data inputs. Two criteria were assessed for the classifier design: F1-score and sensitivity. RFF1_2 and ELMF1_2 provided the highest F1-score values in the validation dataset, (88.17 ± 8.34% and 90.2 ± 4.43%) with the 50th percentile of EHG and obstetric inputs. ELMF1_2 outperformed RFF1_2 in sensitivity, being similar to those of ELMSens (sensitivity optimization). The 10th–90th percentiles did not provide a significant improvement over the 50th percentile. KNN performance was highly sensitive to the input dataset, with a high generalization capability.

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