scholarly journals The effectiveness of umbilical cord milking/ delayed cord clamping and recombinant human erythropoietin in reducing red blood cell transfusions in extremely and very low birth weight infants

2021 ◽  
Vol 20 (3) ◽  
pp. 36-45
Author(s):  
D. R. Sharafutdinova ◽  
E. N. Balashova ◽  
А. R. Kirtbaya ◽  
A. Yu. Ryndin ◽  
J. M. Golubtsova ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Umbilical Cord ◽  
Very Low Birth Weight ◽  
Delayed Cord Clamping ◽  
Low Birth Weight Infants ◽  
Human Erythropoietin ◽  
Cord Clamping ◽  
Red Blood Cell Transfusions ◽  
Umbilical Cord Milking

Anemia of prematurity is one of the most common and serious problems of neonatology. The main focus is to prevent of anemia in preterm infants. The aim of the study was to assess effectiveness of umbilical cord milking/delayed cord clamping and erythropoietin therapy in reducing red blood cell transfusions in extremely and very low birth weight infants. This clinical study was approved by the Commission on ethics of biomedical research (Protocol No. 12 November 17, 2016) and approved by the Scientific Council of National Medical Research Center for obstetrics, gynecology and perinatology named academician V.I. Kulakov of the ministry of Healthcare of the Russian Federation (Protocol No. 19 of November 29, 2016). Analysis of 482 extremely and very low birth weight infants was conducted (from 2008 to 2018). Umbilical cord milking or delayed umbilical cord clamping, both, and in combination with recombinant human erythropoietin therapy, decreasing the phlebotomy losses significantly reduces the need for transfusions of red blood cells in extremely and very low birth weight infants. The effectiveness of erythropoietin therapy, time of its start and various treatment schemes remain controversial, therefore further researches are necessary.

scholarly journals Delayed Umbilical Cord Clamping is Not Associated with Acute Kidney Injury in Very Low Birth Weight Neonates

2019 ◽  
Vol 37 (02) ◽  
pp. 210-215
Author(s):  
Matthew W. Harer ◽  
Ryan M. McAdams ◽  
Mark Conaway ◽  
Brooke D. Vergales ◽  
Dylan M. Hyatt ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Umbilical Cord ◽  
Very Low Birth Weight ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Delayed Cord Clamping ◽  
Cord Clamping ◽  
Umbilical Cord Clamping

Abstract Objective This study aimed to determine if delayed cord clamping (DCC) is associated with a reduction in neonatal acute kidney injury (AKI). Study Design A retrospective single-center cohort study of 278 very low birth weight (VLBW) neonates was performed to compare the incidence of AKI in the following groups: immediate cord clamping (ICC), DCC, and umbilical cord milking. AKI was diagnosed by the modified neonatal Kidney Diseases and Improving Global Outcomes (KDIGO) definition. Results The incidence of AKI in the first week was 20.1% with no difference between groups (p = 0.78). After adjustment for potential confounders, the odds of developing AKI, following DCC, compared with ICC was 0.93 (confidence interval [CI]: 0.46–1.86) with no reduction in the stage of AKI between groups. Conclusion In this study, DCC was not associated with a reduced rate of AKI in VLBW neonates. However, the data suggest that DCC is also not harmful to the kidneys, further supporting the safety of DCC in VLBW neonates.

scholarly journals Effects of delayed cord clamping in very-low-birth-weight infants

2011 ◽  
Vol 31 (S1) ◽  
pp. S68-S71 ◽  
Author(s):  
W Oh ◽  
◽  
A A Fanaroff ◽  
W A Carlo ◽  
E F Donovan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Delayed Cord Clamping ◽  
Low Birth Weight Infants ◽  
Cord Clamping
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