Topical anti-inflammatory activity test and identification of anti-inflammatory active compounds of ether extract of stem bark and leaves resin of tenggulun protium javanicum burm

Anogeissus pendula Edgew has been reported to be used in gastric disorder even though no attempt has been made to evaluate the same. The present study was designed to evaluate the hydroalcoholic extracts of stem bark and leaves for in vivo acute antiulcer and anti-inflammatory activities. Antiulcer activity was studied by pylorus ligation induced ulcers while anti-inflammatory activities was studied by carrageenan induced paw edema. The extract of stem bark at 200 and 400 mg/kg b. w., significantly (P<0.05) reduced ulcer index whereas extracts of both stem bark and leaves significantly (P<0.001) reduced paw diameter at the fifth hour. The hydroalcholic extract of stem bark of A. pendula possesses more significant antiulcer and anti-inflammatory activity than the hydroalcholic extract of leaves may be due to the presence of higher amount of phenolic compounds.

Download Full-text

Identification of phytoconstituents of Tragia involucrata leaf extracts and evaluate their correlation with anti-inflammatory & antioxidant properties

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry ◽

10.2174/1871523020666210126144506 ◽

2021 ◽

Vol 20 ◽

Author(s):

Vinodhini Velu ◽

Swagata Banerjee ◽

Vidya Rajendran ◽

Gaurav Gupta ◽

Dinesh Kumar Chellappan ◽

...

Keyword(s):

Antioxidant Activity ◽

Ethyl Acetate ◽

Petroleum Ether ◽

Ethyl Acetate Extract ◽

Petroleum Ether Extract ◽

Inflammatory Activity ◽

Ether Extract ◽

Membrane Stabilization ◽

Leaf Extracts ◽

Anti Inflammatory

Aims: The present investigation was aimed at exploring the phytoconstituents using Gas Chromatography Mass Spectroscopy and to evaluate antioxidant and anti-inflammatory properties of the leaf extracts. Materials and Methods: The extracts were obtained sequentially with petroleum ether, ethyl acetate and water using soxhlet apparatus. The anti-inflammatory property of the identified compounds using GC- MS spectroscopy was evaluated in silico. The antioxidant activity was performed by DPPH and H2O2 method whereas anti-inflammatory study was carried out by HRBC membrane stabilization method. Terpenoids were found to be major constituents in petroleum ether extract while, phenols and flavonoids were predominantly found in ethyl acetate extract. Results and Discussion: The GC-MS analysis of the extract revealed six major molecules including Squalene, 19β, 28- epoxyleanan-3-ol and 2-tu-Butyl-5-chloromethyl-3-methyl-4-oxoimidazolidine-1-carboxylic acid. The ethyl acetate extract showed a significant antioxidant activity (P<0.01) in both DPPH method (70.87 %) and H2O2 method (73.58%) at 200 µg mL-1 . Increased membrane stabilization of petroleum ether extract was observed in the in vitro anti-inflammatory activity study. A strong relationship between the terpenoid content and anti-inflammatory activity was obtained from the correlation (0.971) and docking study. Conclusion: These results justify T. involucrata to be a rich source of terpenoids with potent antiinflammatory property.

Download Full-text

Anti-inflammatory Activity Test for Ethanol Extract Moon Flower (Tithonia diversifolia) Leaves to Male White Mice

Proceedings of the International Conference on Health Informatics and Medical Application Technology ◽

10.5220/0009974705510557 ◽

2019 ◽

Author(s):

Basyariah Lubis ◽

Ika Nur Saputri ◽

Rony Ajartha ◽

Sri Melda Br Bangun ◽

Chandra Pranata ◽

...

Keyword(s):

Ethanol Extract ◽

Inflammatory Activity ◽

Tithonia Diversifolia ◽

Activity Test ◽

Anti Inflammatory

Download Full-text

Medicinal properties of Ocotea bullata stem bark extracts: phytochemical constituents, antioxidant and anti-inflammatory activity, cytotoxicity and inhibition of carbohydrate-metabolizing enzymes

Journal of Integrative Medicine ◽

10.1016/j.joim.2018.02.007 ◽

2018 ◽

Vol 16 (2) ◽

pp. 132-140 ◽

Cited By ~ 5

Author(s):

Akintayo Lanre Ogundajo ◽

Lateef Apollo Adeniran ◽

Anofi Omotayo Ashafa

Keyword(s):

Stem Bark ◽

Inflammatory Activity ◽

Metabolizing Enzymes ◽

Medicinal Properties ◽

Phytochemical Constituents ◽

Anti Inflammatory

Download Full-text

Antibacterial, Antioxidant and Anti-Inflammatory Potential of the Different Extracts of Holoptelia Integrifolia

International Journal of Engineering and Advanced Technology - Regular Issue ◽

10.35940/ijitee.a9584.119119 ◽

2019 ◽

Vol 9 (2) ◽

pp. 5234-5240

Keyword(s):

Antioxidant Activities ◽

Radical Scavenging ◽

Ethanolic Extract ◽

Stem Bark ◽

Inflammatory Activity ◽

Diffusion Method ◽

Albino Rats ◽

Nitric Oxide Radical ◽

Anti Inflammatory ◽

Wistar Albino Rats

Medicinal plants are play significant impact in the personal medicine for most of the people all over the world as an alternative live saving medicines and most of their medicinal properties are well known for anticancer activity. The different extracts of Holoptelea integrifolia (H.integrifolia) leaves, stem bark and fruits were studied as a potent natural source of antimicrobial, antioxidant and wound healing potential. This work was carried out to evaluate antimicrobial, antioxidant and anti-inflammatory activity of different extracts of H.integrifolia. The antimicrobial activity of the H.integrifolia ethanolic extract was studied against five fungal and bacterial strains by utilizing the agar well diffusion method and MIC. Among several strain, the ethanolic extract of fruit has shown higher antimicrobial inhibition zone as 9.25-16 mm compare to other two extracts of stem and leaves as 10- 13.25 mm and 6-10.2 mm respectively. The antioxidant activities for different extract were also determined by DPPH free radical assay, Hydroxyl Radical Scavenging and Nitric Oxide Radical Scavenging Activity method. The anti-inflammatory activity also estimated basedon formalin induced paw edema method on Wistar albino rats. The different extracts of leaves, stem bark and fruit parts of Holoptelea integrifolia were estimated for in vivo anti-inflammatory activity against the animal model of female Wistar albino rats. The results of anti-inflammatory activity revealed that the Ethanol extracts showed vital and dose-dependent anti-inflammatory effects. Our findings revealed that aerial parts of H.integrifolia contais potential antimicrobial, antioxidant and anti-inflammatory compounds, which expose the medicinal potential of the selected plant could be a significant drug candidates against microbial, oxidative and inflammation-related pathological processes as a future alternative medicine.

Download Full-text

Comparative evaluation of antioxidant and anti‐inflammatory activity of active compounds identified in Ardisia elliptica extracts from different plant parts

Chemistry & Biodiversity ◽

10.1002/cbdv.202100796 ◽

2021 ◽

Author(s):

Hathairat Buraphaka ◽

Watthika Puttha ◽

Waraporn Putalun

Keyword(s):

Comparative Evaluation ◽

Inflammatory Activity ◽

Active Compounds ◽

Plant Parts ◽

Anti Inflammatory ◽

Ardisia Elliptica

Download Full-text

Anti-inflammatory activity of root bark and stem bark of Shyonaka

Journal of Ayurveda and Integrative Medicine ◽

10.4103/0975-9476.104434 ◽

2012 ◽

Vol 3 (4) ◽

pp. 194 ◽

Cited By ~ 7

Author(s):

Rabinarayan Acharya ◽

BR Patel ◽

B Ravishankar ◽

Krunal Doshi ◽

R Ilanchezhian

Keyword(s):

Stem Bark ◽

Inflammatory Activity ◽

Root Bark ◽

Anti Inflammatory

Download Full-text

ANTI-INFLAMMATORY ACTIVITY OF KNEMA ATTENUATA (HOOK. F. AND THOMSON) WARB ETHANOLIC STEM BARK EXTRACT IN ALBINO WISTAR RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i4.30500 ◽

2019 ◽

pp. 330-334

Author(s):

SUPRIYA RAJA H

Keyword(s):

Stem Bark ◽

Inflammatory Activity ◽

Assay Method ◽

Bark Extract ◽

Raw 264.7 ◽

Myeloperoxidase Activity ◽

Stem Bark Extract ◽

Anti Inflammatory

Objective: Knema attenuata (Myristicaceae), popularly known as “wild nutmeg,” is an endemic tree species from Western Ghats, which has been used in folk medicine. Conventionally, the stem bark of K. attenuata is used for treating inflammatory conditions without any scientific information available for the same. The present study was undertaken to evaluate the anti-inflammatory activity of the ethanolic stem bark extract (ESBE) of K. attenuata using in vivo and in vitro screening models. Methods: The ethanolic extract of stem bark was prepared by soxhlation, and its cytotoxicity in RAW 264.7 cell line was assessed using MTT assay method. In vivo anti-inflammatory effect of extract was estimated in rats using carrageenan-induced paw edema model and cotton pellet-induced granuloma model. The in vitro anti-inflammatory activity of the extract was evaluated by cyclooxygenase and lipoxygenase inhibition assay, estimation of myeloperoxidase activity, and determination of cellular nitrite levels in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. Results: Toxic symptoms were not observed for the ESBE. The extract demonstrated significant anti-inflammatory activity in both in vivo and in vitro models. The anti-inflammatory action exhibited by the extract was a result of the inhibition of leukocyte migration and nitric oxide pathway and partially by inhibition of mediators such as prostaglandins and leukotrienes. Conclusion: Findings from the study provide the evidence for the popular use of stem bark extract of K. attenuata as a potential anti-inflammatory agent.

Download Full-text