Maturation and Open-Field Behavior in Rats Exposed Prenatally to an ELF Low-Intensity Rotating Magnetic Field

1972 ◽  
Vol 30 (2) ◽  
pp. 371-374 ◽  
Author(s):  
Klaus-Peter Ossenkopp
Keyword(s):  
Magnetic Field ◽  
Open Field ◽  
Prenatal Development ◽  
Rotating Magnetic Field ◽  
Control Group ◽  
Absorption Mechanism ◽  
Open Field Behavior ◽  
Field Situation ◽  
Significant Difference ◽  
Eye Opening

Rats that had been exposed continuously during their prenatal development to a 3 to 12 gauss, 0.5-Hz rotating magnetic field (RMF) were significantly retarded, in comparison to the control group, in time of eye opening ( p < .01) and time of teeth eruption ( p < .01) but did not differ significantly in maturation of startle response. RMF-exposed animals traversed significantly fewer squares than their controls in an open-field situation ( p < .01), but defecated ( p < .05) and urinated ( p < .01) significantly more often, as well as entering the center circle in the open field significantly less often ( p < .01). There was no significant difference in the number of rearing responses for the two groups. Reference is made to Ludwig's mathematical hypothesis concerning the absorption mechanism of ELF-waves in the nervous system.

Prenatal Exposure to an ELF Rotating Magnetic Field, Ambulatory Behavior, and Lunar Distance at Birth: A Correlation

1971 ◽  
Vol 28 (2) ◽  
pp. 435-438 ◽  
Author(s):  
Michael A. Persinger
Keyword(s):  
Magnetic Field ◽  
Open Field ◽  
Prenatal Exposure ◽  
Prenatal Development ◽  
Rotating Magnetic Field ◽  
Open Field Activity ◽  
Field Situation ◽  
Field Activity ◽  
The Relationship

A significant correlation of 877 between lunar distance at the time of birth and the number of squares traversed in a open-field situation 21 to 25 days later was found for 19 litters that had been exposed continuously during their prenatal development to a 0.5 Hz, 3 to 30 gauss Rotating Magnetic Field (RMF), over a year. RMF-exposed litters that were born on or near lunar perigees traversed fewer squares in an open field than those born on or near apogees. RMF-exposed litters tested “blind” also showed the relationship between lunar distance at time of birth and later open-field activity. 12 control litters did not show a significant correlation (.101).

scholarly journals Effects of Paeonia lactiflora Extract on Estrogen Receptor β, TPH2, and SERT in Rats with PMS Anxiety

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jieqiong Wang ◽  
Chunhong Song ◽  
Dongmei Gao ◽  
Sheng Wei ◽  
Wenjun Sun ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Open Field ◽  
Field Test ◽  
Tryptophan Hydroxylase ◽  
Open Field Test ◽  
Control Group ◽  
Estrus Cycle ◽  
Paeonia Lactiflora ◽  
Total Distance ◽  
Significant Difference

This study is to investigate the effect of Paeonia lactiflora extract on PMS anxiety and on expression of estrogen receptor β (ERβ), tryptophan hydroxylase-2 (TPH2), and serotonin transporter (SERT) in the premenstrual syndrome (PMS) anxiety model rats. The vaginal smear and open field test were used to screen rats in nonreception phase of estrus cycle with similar macroscopic behaviors and regular estrus cycle. PMS anxiety model rats were prepared by electrical stimulation. RT-PCR and immunofluorescence were used to measure the expression of ERβ, TPH2, and SERT. Compared with normal rats, the total distance in the open field test of the model rats was significantly increased (P<0.05). The model rats showed nervous alertness, irritability, and sensitivity to external stimuli. After treatment with the Paeonia lactiflora extract, the total distance of rats was significantly reduced (P<0.05). In reception stage, there was no significant difference in the mRNA and protein expression of ERβ, TPH2, and SERT. In nonreception stage, the expression of ERβ and TPH2 in the model group was significantly decreased (P<0.05) as compared with the control group, but not SERT. Abnormal changes of the above indicators were reversed after the administration of the Paeonia lactiflora extract. In conclusion, Paeonia lactiflora extract can increase the expression of ERβ and TPH2 and decrease SERT in PMS model rats, which may be one of the mechanisms underlying the effect of Paeonia lactiflora extract on PMS.

scholarly journals GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior

2019 ◽  
Author(s):  
Chihiro Nakamoto ◽  
Meiko Kawamura ◽  
Ena Nakatsukasa ◽  
Rie Natsume ◽  
Keizo Takao ◽  
...  
Keyword(s):  
Social Interaction ◽  
Open Field ◽  
Forced Swim Test ◽  
Sensorimotor Gating ◽  
Fear Memory ◽  
Control Group ◽  
Behavioral Differences ◽  
Novelty Preference ◽  
Plus Maze ◽  
Significant Difference

AbstractThe GluD1 gene is associated with susceptibility for schizophrenia, autism, depression, and bipolar disorder. However, the function of GluD1 and how it is involved in these conditions remain elusive. In this study, we generated a GluD1-knockout (GluD1-KO) mouse line with a pure C57BL/6N genetic background and performed several behavioral analyses. Compared to a control group, GluD1-KO mice showed no significant anxiety-related behavioral differences, evaluated using behavior in an open field, elevated plus maze, a light-dark transition test, the resident-intruder test of aggression and sensorimotor gating evaluated by the prepulse inhibition test. However, GluD1-KO mice showed (1) hyper locomotor activity in the open field, (2) decreased sociability and social novelty preference in the three-chambered social interaction test, (3) impaired memory in contextual, but not cued fear conditioning tests, and (4) enhanced depressive-like behavior in a forced swim test. Pharmacological studies revealed that enhanced depressive-like behavior in GluD1-KO mice was restored by the serotonin reuptake inhibitors imipramine and fluoxetine, but not the norepinephrine transporter inhibitor desipramine. In addition, biochemical analysis revealed no significant difference in protein expression levels, such as other glutamate receptors in the synaptosome and postsynaptic densities prepared from the frontal cortex and the hippocampus. These results suggest that GluD1 plays critical roles in fear memory, sociability, and depressive-like behavior.

Changes in Open-Field Behavior following Short-Term Alcohol Ingestion by Rats

1975 ◽  
Vol 37 (2) ◽  
pp. 575-578 ◽  
Author(s):  
Nigel W. Bond ◽  
Eros L. Digiusto
Keyword(s):  
Open Field ◽  
Liquid Diet ◽  
Alcohol Ingestion ◽  
Nutritional Deficiencies ◽  
Control Group ◽  
Short Term ◽  
Open Field Behavior ◽  
Emotional Responding ◽  
Male Wistar Rats ◽  
Free Feeding

24 adult male Wistar rats were reduced to 70% of their free-feeding body weight and then randomly divided into an experimental and a control group. The former was placed on a liquid diet consisting of alcohol plus Sustagen for 4 2-day periods interspersed with 3 2-day periods of a liquid diet containing Sucrose plus Sustagen. The latter group which was pair fed with the experimental group received the latter diet only. An 8-day period followed in which all animals were fed their normal laboratory diet ad lib. All rats were subsequently tested for differences in activity and defecation in an open field for 15 min. per day every other day for 3 days. The results showed that short-term alcohol ingestion can lead to residual behavioral changes, an enhancement of the activating effects of novel stimuli on locomotor activity which were independent of emotional responding or nutritional deficiencies.

scholarly journals Effect of hydration with Ringer's solution submitted to magnetic field in an experimental model of hepatic ischemia-reperfusion injury in rats

2018 ◽  
Vol 9 (2) ◽  
pp. 44-53
Author(s):  
Juliana Mendonça Freire ◽  
Jeovana Pinheiro Fernandes de Souza ◽  
Italo Medeiros Azevedo ◽  
Fabio Medeiros de Azevedo ◽  
Artur Da Silva Carriço ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Experimental Model ◽  
Ischemia Reperfusion ◽  
Test Group ◽  
Control Group ◽  
Hepatic Ischemia ◽  
Left Liver ◽  
Ringer’S Solution ◽  
Significant Difference ◽  
Hepatic Ischemia Reperfusion

Purpose: To evaluate the effect of hydration with Ringer's solution submitted to magnetic field in experimental model of hepatic ischemia/reperfusion in rats. Methods: Wistar rats weighing 389.58±46.88g were randomly allocated into 2 groups: control group (n = 6) - Hepatic ischemia/reperfusion and hydration with Ringer's solution; and test group (n = 6) - Hepatic ischemia/reperfusion and hydration with Ringer submitted to magnetic field of 20 mT during 2 hours. After anesthesia with ketamine 70 mg/kg and xylazine 7 mg/kg i.p., the animals were weighed and operated by aseptic technique. The ischemia of the median and left liver lobes was induced for 30 minutes using a vascular clip. Then, i.v. hydration with 3 ml of Ringer in the control group, and 3 ml of magnetized Ringer’s solution in the test group. After 24 hours, blood sample and fragment of the left liver lobe were collected for the determination of AST, ALT, ALP and albumin levels, and histopathological examination. Results: There was no significant difference in comparison of the rats weight loss, biochemical measurements and histopathological scores between the groups (p>0.05). Conclusion: The hydration with Ringer's solution submitted to magnetic field after hepatic ischemia/reperfusion in rats did not alter liver function tests neither histopathological scores, comparing with the control group.

Effects of acute topiramate dosing on open field behavior in mice

2001 ◽  
Vol 19 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Klaus Ruback Bertges ◽  
Luiz Carlos Bertges ◽  
José Olimpio Tavares De Souza ◽  
Juliana Clemente Machado ◽  
Carlos Alberto Mourao Junior
Keyword(s):  
Treatment Group ◽  
Open Field ◽  
Open Field Test ◽  
Central Area ◽  
Test Method ◽  
Control Group ◽  
Open Field Behavior ◽  
Learning Anxiety ◽  
Immobility Time ◽  
Field Test Method

Although topiramate (TPM) has been used to treat human disease, there are few studies of its effects on the behavior of animal models. Objective. This study aimed to assess the effect of acute TPM administration on the behavior of mice undergoing the open-field test. Method. The animals were divided in two groups: the treatment group (n = 10), which received 10 mg/kg TPM intraperitoneally, and the control group (n = 10), which received saline. 30 minutes after drug administration, the animals were assessed for 5 minutes in the open-field. The following parameters were analyzed: number of squares explored, immobility time, central area permanence time, peripheral apparatus permanence time, rearing frequency and time, grooming frequency and time, rearing frequency during the last minute, number of fecal boli, and estimated speed. Results. The treatment group had a higher number of squares explored (p = 0.02) and greater estimated speed (p = 0.01). Conclusion. The results suggest that acute TPM administration increases the locomotor activity of mice without interfering with learning, anxiety, stress, and exploratory behavior.

Behavior of the Guinea Pig in the Open-Field Situation

1966 ◽  
Vol 18 (2) ◽  
pp. 415-425 ◽  
Author(s):  
E. Tobach ◽  
P. S. Gold
Keyword(s):  
Guinea Pig ◽  
Open Field ◽  
Guinea Pigs ◽  
Field Experience ◽  
Home Cage ◽  
Open Field Behavior ◽  
Male And Female ◽  
Heterogeneous Stock ◽  
Field Situation ◽  
Field Manipulation

The open-field behavior of male and female guinea pigs of heterogeneous stock and age was studied in one experiment; in a second experiment six-week-old male pigs of the Hartley strain were observed. In both experiments the open-field situation tended to inhibit elimination in the open field, and in the first experiment the open-field experience also delayed elimination in the home cage after observation in the open field. Manipulation without open-field experience did not have this effect. In both studies, the animals tended to stay in the center of the open-field enclosure as the trials progressed and there was little locomotion in the open field.

A Study on Early Apoptosis of Hepatoma Bel-7402 Cells In Vitro Treated by Altering-Electric Magnetic Field Exposure of Extremely Low Frequency Combined with Magnetic Nano-Fe3O4 Powders

2013 ◽  
Vol 364 ◽  
pp. 742-748 ◽  
Author(s):  
Zhi Qiang Chen ◽  
Jian Wen ◽  
Wen Yong Tu ◽  
Li Xiao ◽  
Zheng Fang
Keyword(s):  
Magnetic Field ◽  
Cell Metabolism ◽  
Low Frequency ◽  
Control Group ◽  
Cell Physiology ◽  
Field Exposure ◽  
Extremely Low Frequency ◽  
Significant Difference ◽  
Early Apoptosis

An investigation was made on the early apoptosis of hepatoma Bel-7402 cells, which were cultured on the magnetic nanoFe3O4 powders in different diameters (MNPs) in vitro, by an altering electro-magnetic field (ELFF) exposure of extremely low frequency. MNPs would strengthen the ELFF effects on the cell metabolism, and the effects were dependent on the diameter of powders. The experiments showed that MNPs could not influence the cell physiology obviously. However, ELFF exposure would inhibit the cell proliferation because some cells were arrested at G0/G1 period and the early apoptosis was induced with significant difference (P<0.05) as compared with the control group. The combination of MNPs with ELFF could strengthen the ratio of cells arrested at G0/G1 period and induced early apoptosis. As compared with the control group and the radiation group by ELFF with effects to cells ion metabolism, the significant difference was also present (P<0.05). The western-blot and patch-clamp experiments showed that the mechanism on the combined method was the same as that of the single ELFF exposure and treated by 40nm MNPs could be induced more cells into early apoptosis than those by the 80nm powders combined with ELFF.

Geophysical Variables and Behavior: XI. Open-Field Behaviors in Young Rats Exposed to an ELF Rotating Magnetic Field

1983 ◽  
Vol 52 (2) ◽  
pp. 343-349 ◽  
Author(s):  
Klaus-Peter Ossenkopp ◽  
Margitta D. Ossenkopp
Keyword(s):  
Magnetic Field ◽  
Open Field ◽  
Rotating Magnetic Field ◽  
Male Rats ◽  
Albino Rats ◽  
Activity Levels ◽  
Experimental Conditions ◽  
Male And Female ◽  
And Behavior ◽  
And Control

Male and female albino rats 27 days of age were exposed to a 0.5-Hz rotating magnetic field (RMF) (2-30 gauss) for 21 days. Both experimental and control rats were tested in an open-field apparatus prior to imposition of experimental conditions, at 7, 15, and 21 days after the start of the experiment, and a final test occurred 3 days after the magnets were removed from the RMF apparatus. Male rats increased their activity levels and decreased their latency to ambulate in the open field, relative to control rats. The female experimental rats did not differ from controls on these measures. Both male and female RMF-exposed rats defecated less than control rats. Effects on latency and activity were still evident 3 days after removal of the magnets. These results indicate that exposure to a 0.5-Hz RMF makes rats less emotionally reactive to novel situations. It is suggested that these effects may be mediated by an effect of the RMF on the pineal gland.

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