Relaxation Increases Salivary Immunoglobulin a

1987 ◽  
Vol 61 (2) ◽  
pp. 623-629 ◽  
Author(s):  
Ronald G. Green ◽  
Marsha L. Green
Keyword(s):  
Immune System ◽  
Salivary Cortisol ◽  
Immunoglobulin A ◽  
High Stress ◽  
Relaxation Response ◽  
Control Group ◽  
Coping Skill ◽  
Relaxation Methods ◽  
Eyes Closed ◽  
Salivary Immunoglobulin A

While research indicates that high stress may be immunosuppressive, little is known about the effects of relaxation on the immune system. To determine whether relaxation is immunoenhancing, 50 volunteer college students were randomly assigned to one of four relaxation methods (Benson's relaxation response, guided visualization, massage, lying quietly with eyes closed, or a touching-control group). Salivary immunoglobulin A (S-IgA) and salivary Cortisol levels were recorded before and after one 20-min. relaxation session. Subjects in the relaxation response, visualization, and massage groups showed a significant increase in S-IgA concentrations from the before to the after relaxation samples. Also, post-relaxation S-IgA concentrations were significantly higher in the relaxation response, visualization, and massage groups than in the touching-control group. Salivary Cortisol did not change significantly. These data suggest that one component of the immune system, S-IgA, may be enhanced by the practice of a coping skill such as relaxation.

Psychological and Physiological Response of Students to Different Types of Stress Management Programs

2012 ◽  
Vol 26 (6) ◽  
pp. e149-e158 ◽  
Author(s):  
Silvia L. Iglesias ◽  
Sergio Azzara ◽  
Juan Carlos Argibay ◽  
María Lores Arnaiz ◽  
María de Valle Carpineta ◽  
...  
Keyword(s):  
Respiratory Rate ◽  
Stress Management ◽  
Salivary Cortisol ◽  
Guided Imagery ◽  
Relaxation Response ◽  
Control Group ◽  
Deep Breathing ◽  
Different Types ◽  
Cortisol Levels ◽  
Imagery Techniques

Purpose. To design, implement, and examine the psychoneuroendocrine responses of three different types of stress management programs. Design. Randomly assigned. A pre/post experimental design comparing variables between three different programs and a control group. The first program included training in deep breathing, relaxation response, meditation, and guided imagery techniques (RRGI). The second program included training in cognitive behavioral techniques (CB). The third program included both RRGI and CB (RRGICB). Setting. The study was conducted at Buenos Aires University. Subjects. Participants (N = 52) were undergraduate students. Measures. Anxiety, anger, hopelessness, neuroticism, respiration rate, and salivary cortisol levels were assessed. Analysis. Wilcoxon signed rank test was used to investigate differences in pre and post variables. Results. Subjects in the RRGI group showed significantly lower levels of anxiety (p < .011), anger (p < .012), neuroticism (p < .01), respiratory rate (p < .002), hopelessness (p < .01), and salivary cortisol (p < .002) after the treatment. Subjects in the CB group showed significantly lower levels of anxiety (p < .018), anger (p < .037), and neuroticism (p < .03) after the treatment. Subjects in the RRGICB group showed significantly lower levels of anxiety (p < .001), anger (p < .001), neuroticism (p < .008), hopelessness (p < .01), respiratory rate (p < .001), and salivary cortisol (p < .002) after the treatment. Subjects in the control group showed only one variable modification, a significant increase in cortisol levels (p < .004). Conclusions. The combination of deep breathing, relaxation response, meditation, and guided imagery techniques with CB seems to be effective at helping people to deal with stress.

scholarly journals Peculiarities of immunore resistance changes in the experiment of induced peritonitis in animals of different ages

2019 ◽  
Keyword(s):  
Immune System ◽  
Humoral Immunity ◽  
Phagocytic Activity ◽  
Immunoglobulin A ◽  
The Body ◽  
Control Group ◽  
Adaptive Responses ◽  
Inflammation Model ◽  
Different Ages ◽  
Old Rats

Introduction. The protection of the body against external and internal antigenic factors is executed with the help of the primary cellular and secondary resistance links. Excessive activation of adaptation reactions leads to the formation of various pathologies of inflammatory nature. Changes in the immune responses occur at all ontogenesis stages. In the present study, we conduct the experiment of induced peritonitis in animals of different ages in order to investigate more accurately adaptive responses of the immune system during inflammation. Objectives. The aim of our research was to study changes in the indicators of adaptive humoral immunity, levels of immunoglobulin A and circulating immune complexes, phagocytic activity of neutrophils and the disruption of enzymes activity, which provide the phagocyte function in the NST test on the model of induced peritonitis in animals of different ages. Materials and methods. The studies were performed on 200 white male rats. They were divided into a control group and the experimental rats, 3- and 22-month-old ones. Acute inflammation and dysbiosis in the small intestine were caused by intraperitoneal injection of lipopolysaccharide obtained from Escherichia coli strain. The material for the study was serum and blood elements of experimental animals. Results. The levels of immunoglobulin A in the blood serum of 3 and 22-month-old rats with the inflammation model were reduced in comparison with this index in control group animals. The content of the CIC in the rats blood serum of both age groups was significantly higher in comparison with the control group. All the studied indices of neutrophils phagocytic activity in the 22-month-old animals with the inflammation model were lower than in the control rats of this age. In the 3-month-old rats with the inflammation model, the index of phagocytosis completeness was significantly lower in comparison with the control group. The reduction in the reserve capacity of phagocytic cells was higher in the 22-month-old animals. An increase in the neutrophils metabolic activity and a decrease in their metabolic reserve in 3 and 22-month-old rats with the inflammation model were revealed in comparison with the parameters of the control groups. Conclusions. The results of the study indicate presence of violation of the primary cellular and secondary humoral immunity during the aging of the body and decrease in the adaptive responses of the immune system during inflammation due to an increase in antigenic effects.

scholarly journals Choral Singing, Performance Perception, and Immune System Changes in Salivary Immunoglobulin A and Cortisol

2000 ◽  
Vol 18 (1) ◽  
pp. 87-106 ◽  
Author(s):  
R. J. Beck ◽  
T. C. Cesario ◽  
A. Yousefi ◽  
H. Enamoto
Keyword(s):  
Immune System ◽  
Rating Scales ◽  
Immunoglobulin A ◽  
Multiple Regression Model ◽  
System Response ◽  
Secretory Immunoglobulin A ◽  
Public Performance ◽  
Choral Singing ◽  
Salivary Immunoglobulin A ◽  
Secretory Immunoglobulin

In a naturalistic pre-post design, samples of saliva were collected from the members of a professional chorale during an early rehearsal (n = 31), a late rehearsal (n = 34) and a public performance (n = 32) of Beethoven's Missa Solemnis. As measures of immune system response, mean levels of secretory immunoglobulin A increased significantly, as a proportion of whole protein, 150% during rehearsals and 240% during the performance. Cortisol concentrations decreased significantly an average of 30% during rehearsals and increased 37% during performance. As measured through performance perception rating scales, a group of emotions and other experiential states that singers associated with professional singing were highly predictive of changes in level of secretory immunoglobulin A during the performance condition, but the results for the rehearsal conditions were not significant. The best multiple regression model for performance level of immunoglobulin A (p &lt; .0015) included seven emotional, cognitive, and evaluative variables generally associated with choral singing, including levels of mood before and during singing, stress, relaxation, feeling "high," detachment/engagement, and specific satisfaction with the immediate performance.

scholarly journals THE DEGREE OF SECRETORY IMMUNOGLOBULIN A IN BURN PATIENTS WITH PROBIOTIC THERAPY

2019 ◽  
pp. 174-176
Author(s):  
LYNDA HARIANI ◽  
IRAWAN WAHYUDI ◽  
ISWINARNO DOSOSAPUTRO ◽  
SJAIFUDDIN NOER M
Keyword(s):  
Immune System ◽  
Immunoglobulin A ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Secretory Immunoglobulin A ◽  
Burn Patients ◽  
Double Blind ◽  
And Control ◽  
Secretory Immunoglobulin ◽  
Regular Intake

Background: One of the problems with burn patients is the impairment of host immunity, which makes difficult to treat. In burns, immunoglobulinA has demonstrated to decrease. Immunoglobulin A is the main product of mucous immune system, which increases viral clearance and decreasesbacterial adhesion in the intestine. Probiotics consist of living microflora, which control the balance of lactobacilli and bifidobacteria in the intestine.Instead of producing organic component, increasing the acidity of intestine, mucin and bacteriocin, they also activate the intestinal immune systemand secretory immunoglobulin A (sIgA). The goal of this study was to propose that regular intake of probiotic might help to improve the mucousimmune system, especially sIgA in intestines in burn patients.Methods: An experimental, double-blind, controlled clinical trial was carried out in 33 burn patients. Those patients were divided into two groups.The first group was given daily probiotic and the second group was given only placebo for 10 days. The treatment began on the 4th day admission, andthen, the degree of sIgA was evaluated before treatment and day 14 from fecal specimen.Results: Significant differences between probiotic and control group were observed (p<0.0001). The degree of sIgA in the probiotic group increased61.25%, and in the control group, it decreased to 36.80%.Conclusion: The mucous immune system, especially sIgA, increases by probiotic intake.

scholarly journals Circadian Rhythm of Salivary Immunoglobulin A and Associations with Cortisol as A Stress Biomarker in Captive Asian Elephants (Elephas maximus)

Animals ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 157 ◽  
Author(s):  
Tithipong Plangsangmas ◽  
Janine L. Brown ◽  
Chatchote Thitaram ◽  
Ayona Silva-Fletcher ◽  
Katie L. Edwards ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Salivary Cortisol ◽  
Least Squares Method ◽  
Linear Trend ◽  
Immunoglobulin A ◽  
Generalized Least Squares ◽  
Asian Elephants ◽  
Generalized Least Squares Method ◽  
Cortisol Responses ◽  
Salivary Immunoglobulin A

Salivary immunoglobulin A (sIgA) has been proposed as a potential indicator of welfare for various species, including Asian elephants, and may be related to adrenal cortisol responses. This study aimed to distinguish circadian rhythm effects on sIgA in male and female Asian elephants and compare patterns to those of salivary cortisol, information that could potentially have welfare implications. Subjects were captive elephants at an elephant camp in Chiang Mai province, Thailand (n = 5 males, 5 females). Salivette® kits were used to collect saliva from each elephant every 4 h from 06:00 to 22:00 h for 3 consecutive days (n = 15 samples/elephant). Enzyme immunoassays were used to quantify concentrations of IgA and cortisol in unextracted saliva. Circadian rhythm patterns were determined using a generalized least-squares method. Both sIgA and cortisol followed a circadian rhythm, although the patterns differed. sIgA displayed a daily quartic trend, whereas cortisol concentrations demonstrated a decreasing linear trend in concentrations throughout the day. There was no clear relationship between patterns of sIgA and salivary cortisol, implying that mechanisms of control and secretion differ. Results demonstrate for the first time that circadian rhythms affect sIgA, and concentrations follow a daily quartic pattern in Asian elephants, so standardizing time of collection is necessary.

scholarly journals Mini-Review Article – Current Opinion on Salivary Biomarkers as a Measurement for Stress and Fatigue

2013 ◽  
Vol 6 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Ting Chun Yi ◽  
Shabbir Moochhala
Keyword(s):  
Salivary Cortisol ◽  
Immunoglobulin A ◽  
Individual Variability ◽  
Review Article ◽  
Salivary Amylase ◽  
Non Invasive ◽  
Salivary Peptide ◽  
Stress Research ◽  
Salivary Biomarkers ◽  
Salivary Immunoglobulin A

Salivary biomarkers have been increasingly popular in stress research as saliva is easily produced and collection is non-invasive and not limited by geographical distance or lack of infrastructure. Several salivary biomarkers have been utilized in stress research, for instance, salivary cortisol, salivary amylase and salivary immunoglobulin A. Despite being sensitive to changes in fatigue, they have limitations such as inter-individual variability, and interactions with other constituents that may confound the results. Recently, Hyperion Biotechnology has developed the Fatigue Biomarker Index (FBI), which is a measurement of the changes in concentration of salivary peptides with fatigue. The FBI has been shown to be an accurate and objective biomarker of fatigue, and has huge potential for use in various fields and industries. This article will review some of the previous and current salivary biomarkers of stress, as well as critically appraise the new salivary peptide test in terms of its accuracy, application and access.

Effect of Positive Psychological Intervention on Well-Being, 2-Week Illness Prevalence, and Salivary Immunoglobulin A

2017 ◽  
Vol 40 (6) ◽  
pp. 889-906 ◽  
Author(s):  
Miaomiao Jiang ◽  
Zhiqin Yin ◽  
Sijiao Li ◽  
Xiaolin Chen ◽  
Jiahuan Gu
Keyword(s):  
Mental Health ◽  
Psychological Intervention ◽  
Immunoglobulin A ◽  
Intervention Group ◽  
Well Being ◽  
Control Group ◽  
Physical And Mental Health ◽  
Significant Difference ◽  
Salivary Immunoglobulin A ◽  
Positive Psychological Intervention

The study aims to explore the effect of positive psychological intervention (fun activities combined with positive mental health education) on the well-being, 2-week illness prevalence, and salivary immunoglobulin A of empty nesters. Ninety-two empty nesters were divided into intervention ( n = 49) and control ( n = 43) groups. The empty nesters in the intervention group performed the intervention in addition to routine community activities. The intervention group scored significantly higher on well-being ( p< .05) compared with the control group after intervention. A week after intervention, salivary immunoglobulin A of the intervention group ( p< .05) was higher than that before intervention. Meanwhile, the difference in salivary immunoglobulin A in the control group before and after intervention was not statistically significant. 2-week illness prevalence in both groups did not exhibit a significant difference ( p> .05). Results indicate that positive psychological intervention can effectively increase the well-being and salivary immunoglobulin A of empty nesters and improve their physical and mental health.

Dynamics of index of immune system after prevention of disorders in menopause of women with hyperproliferative processes of reproductive system

2017 ◽  
pp. 100-104
Author(s):  
L.I. Butina ◽  
Keyword(s):  
Immune System ◽  
Emotional Disorders ◽  
Reproductive System ◽  
Immunoglobulin A ◽  
Control Group ◽  
Response Modifier ◽  
Before And After ◽  
Ig G ◽  
Immune Response Modifier ◽  
Necrosis Factor

The objective: to evaluate the effectiveness of prevention of disorders in menopause of women with hyperproliferative processes of reproductive system (HPPRS) on the basis of investigations of the index of immune system. Materials and methods. The substitutive hormone prevention (SHP) of neurovegetative and psycho-emotional disorders in menopause (NVPDM) was conducted among 60 women aged 40 to 53 with the signs of HPPRS according to the data of ultrasound uterine and the results of histological investigations of mucosal scrapings of the uterus. and the appointment of combine estrogen-gestogen preparation with composition of valerat of estradiol and dienogest drug according to contraceptive scheme, immune response modifier with acid acridonucsusna and N metilglukamini, suppositories with inteferonum recombinant alfa 2b. To evaluate the effectiveness of prevention of HPPRS the index of the immune system was tested: the level of immunoglobulin A, G, M, (IgA, IgG, IgM) of interleukin 1.2 (IL-1, IL-2), of tumor necrosis factor (TNF) before and after prophylaxis with the use of immunofermentic method were determined. The control group included 30 women of the same age category without NVPDM and HPPRS. Results. Women with premenopause HPPRS have 38% of IgA, 21% of IgG, 37% of IgM level up, IL-1 – 2.6 times, IL-2 – 2.6 times up and TNF 47% up (р<0.05), compared with healthy women. After SHP use among women with preserving menstrual function (n=24) the levels of IL-1decreased in 2.4 times, IL – for 43%, TNF for 28%; (р<0.05). Among women with the development of menopause (n=36) – Ig A level decreased to 34%, Ig G – to 37%, IL2 to 15% in comparison with the indices before the prophylaxis.was conducted (р<0,05), The symptoms of NVPDM among 40% women disappeared. Conclusions. The use of SHP of NVPDM among women with HPPRS reduces the exertion of immunologic reaction and reduces the risk of denutrition of their compensatiory possibilities. and allows to liquidate NVPDM for 40% of women in the period of premenopause. Key words: menopausal disorders, hyperproliferative processes of reproductive system, prevention, immune system.

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