scholarly journals Unmetabolized VOCs in urine as biomarkers of low level occupational exposure

Author(s):  
Beata Janasik ◽  
Marek Jakubowski ◽  
Wiktor Wesołowski ◽  
Małgorzata Kucharska
2021 ◽  
Author(s):  
Ann Nakashima ◽  
Oshin Vartanian ◽  
Shawn G Rhind ◽  
Kristen King ◽  
Catherine Tenn ◽  
...  

ABSTRACT Introduction Recently, there has been increasing concern about the adverse health effects of long-term occupational exposure to low-level blast in military personnel. Occupational blast exposure occurs routinely in garrison through use of armaments and controlled blast detonations. In the current study, we focused on a population of breaching instructors and range staff. Breaching is a tactical technique that is used to gain entry into closed spaces, often through the use of explosives. Materials and Methods Initial measurements of blast overpressure collected during breaching courses found that up to 10% of the blasts for range staff and up to 32% of the blasts for instructors exceeded the recommended 3 psi exposure limit. Using a cross-sectional design, we used tests of balance, ataxia, and hearing to compare a sample of breachers (n = 19) to age-and sex-matched military controls (n = 19). Results There were no significant differences between the two groups on the balance and ataxia tests, although the average scores of both groups were lower than would be expected in a normative population. The prevalence of hearing loss was low in the breacher group (4 of 19), and hearing thresholds were not significantly different from the controls. However, the prevalence of self-reported tinnitus was significantly higher in the breacher group (12 of 19) compared with the controls (4 of 19), and all breachers who were identified as having hearing loss also reported tinnitus. Conclusions Our results suggest that basic tests of balance, ataxia, and hearing on their own were not sensitive to the effects of long-term occupational exposure to low-level blast. Some of the blast exposure levels exceeded limits, and there was a significant association of exposure with tinnitus. Future studies should supplement with additional information including exposure history and functional hearing assessments. These findings should be considered in the design of future acute and longitudinal studies of low-level blast exposure.


Author(s):  
Antonio Accorsi ◽  
Barbara Morrone ◽  
Irene Domenichini ◽  
Simona Valenti ◽  
Giovanni Battista Raffi ◽  
...  

2011 ◽  
Vol 214 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Sirilak Wongvijitsuk ◽  
Panida Navasumrit ◽  
Udomratana Vattanasit ◽  
Varabhorn Parnlob ◽  
Mathuros Ruchirawat

2009 ◽  
Vol 31 (3) ◽  
pp. 243-257 ◽  
Author(s):  
Tomoki FUJIO ◽  
Yasushi JYOYAMA ◽  
Shiro YASUI ◽  
Hiromi MICHITSUJI ◽  
Chikako SANEMORI ◽  
...  

1983 ◽  
Vol 64 (2) ◽  
pp. 187-191 ◽  
Author(s):  
R. Tenhunen ◽  
H. Savolainen ◽  
P. Jäppinen

1. Analysis of reticulocytes for δ-aminolaevulinic acid synthase (AmLev synthase, EC 2.3.1.37) and haem synthase (EC 4.99.1.1) activity in 17 workers in pulp production with low-level hydrogen sulphide and methylmercaptan exposure showed decreased activities in eight and six cases respectively. 2. Erythrocyte protoporphyrin concentration was below the control range in seven cases. 3. Low AmLev synthase and haem synthase activities were found in one patient with hydrogen sulphide intoxication 1 week after the event. The activities had returned to the control levels 2 months later, though erythrocyte protoporphyrin remained abnormally low. 4. In vitro, hydrogen sulphide inhibited haem synthase with an apparent Kl of 3.4 mmol/l. Sulphide anion, on the other hand, inhibited AmLev synthase activity 85% at 10 mmol/l concentration. Thiosulphate anion inhibited AmLev synthase activity 18% (Kl 27 mmol/l) and haem synthase activity 43% at 10 mmol/l concentration. Selenite inhibited AmLev synthase (Kl 5.1 mmol/l) and haem synthase (Kl 9.0 mmol/l). 5. The assay of AmLev synthase and haem synthase could be a valuable addition to the assessment of workers' health in industries generating hydrogen sulphide or/and methylmercaptan, although the mechanism of the toxic effect remains speculative.


1988 ◽  
Vol 26 (4) ◽  
pp. 203-214 ◽  
Author(s):  
Shao Ying ZHOU ◽  
You Xin LIANG ◽  
Zi Qiang CHEN ◽  
Yi Lan WANG

2007 ◽  
Vol 28 (1) ◽  
pp. 168-174 ◽  
Author(s):  
Sohel Ahmed ◽  
Tin-Tin-Win-Shwe ◽  
Shoji Yamamoto ◽  
Shinji Tsukahara ◽  
Naoki Kunugita ◽  
...  

1999 ◽  
Vol 235 (1-3) ◽  
pp. 247-252 ◽  
Author(s):  
F. Brugnone ◽  
L. Perbellini ◽  
L. Romeo ◽  
M. Cerpelloni ◽  
M. Bianchin ◽  
...  

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