This work is focused on the landslide susceptibility assessment, applied to Mauritius Island. The study area is a volcanic island located in the western part of the Indian Ocean and it is characterized by a plateau-like morphology interrupted by three rugged mountain areas. The island is severely affected by geo-hydrological hazards, generally triggered by tropical storms and cyclones. The landslide susceptibility analysis was performed through an integrated approach based on morphometric analysis and preliminary Geographical Information System (GIS)-based techniques, supported by photogeological analysis and geomorphological field mapping. The analysis was completed following a mixed heuristic and statistical approach, integrated using GIS technology. This approach led to the identification of eight landslide controlling factors. Hence, each factor was evaluated by assigning appropriate expert-based weights and analyzed for the construction of thematic maps. Finally, all the collected data were mapped through a cartographic overlay process in order to realize a new zonation of landslide susceptibility. The resulting map was grouped into four landslide susceptibility classes: low, medium, high, and very high. This work provides a scientific basis that could be effectively applied in other tropical areas showing similar climatic and geomorphological features, in order to develop sustainable territorial planning, emergency management, and loss-reduction measures.