scholarly journals Where and how to use botulinum toxin on the face and neck – Indications and techniques

2021 ◽  
Vol 1 ◽  
pp. 17
Author(s):  
Gulhima Arora ◽  
Sandeep Arora
Keyword(s):  
Botulinum Toxin ◽  
Clostridium Botulinum ◽  
New Era ◽  
Off Label ◽  
Essential Blepharospasm ◽  
The Us ◽  
The Face ◽  
Injection Techniques ◽  
Muscle Groups ◽  
Label Indication

Botulinum toxin (BT) is a proteinaceous substance that is derived from the bacterium Clostridium botulinum. It was initially used for the treatment of strabismus by Dr. Alan Scott in the late 1970s after which, it was regularly being used for the cosmetic correction of benign essential blepharospasm by the Carruthers couple. Jean Carruthers while treating one such patient noticed an improvement in the glabellar furrows with an effect on the brow of the patient as well. By the late 1980s through the 1990s, BT was used rampantly as an off-label indication to treat glabellar frown lines. In 2002, the US Food and Drug Administration approved the use of BT type A for the treatment of glabellar furrows. This changed the global scene of facial rejuvenation, heralding a new era. Ever since then, BT has proved to be effective and safe for the treatment of dynamic facial rhytides and is currently being used for various indications. These indications and techniques have evolved with a better understanding of the face and neck musculature and their interactions and actions as well as efficacy of the BT formulations. The authors present an overview of the various cosmetic indications of BT for the face and neck along with the approach to injection techniques for various muscle groups involved.

scholarly journals THE EMERGING ROLE OF BOTULINUM TOXIN IN THE TREATMENT OF OROFACIAL DISORDERS: LITERATURE UPDATE

2017 ◽  
Vol 10 (9) ◽  
pp. 21 ◽  
Author(s):  
Santhosh Kumar
Keyword(s):  
Botulinum Toxin ◽  
Clostridium Botulinum ◽  
Anaerobic Bacterium ◽  
Therapeutic Agent ◽  
Treatment Options ◽  
Treatment Protocols ◽  
Adequate Knowledge ◽  
Injection Techniques ◽  
General Dentists

Botulinum toxin (BTX) is a lethal neurotoxin produced by Gram-positive anaerobic bacterium called Clostridium botulinum. It is the first toxin used fortherapeutic purposes since 1989. BTX treatment is relatively safe and efficacious, less invasive, conservative, and the effects are faster and reversible.The purpose of this article is to review the literature regarding the applications of BTX in the treatment of various orofacial disorders, their mechanismof action, contraindications, and complications. From the recently published literature, it is clear that the role of BTX as a therapeutic agent for severalconditions is expanding. With the training of BTX-A injection techniques and adequate knowledge about treatment protocols, general dentists cansafely administer BTX injections. The ability to use Botox as an adjuvant and primary mode of the treatment for various maxillofacial disorders offersexciting treatment options for dentists and patients in the future.

scholarly journals Botulinum Toxin for the Face

2021 ◽  
Author(s):  
Amin Amer ◽  
Mohamed Amer ◽  
Hagar Nofal
Keyword(s):  
Botulinum Toxin ◽  
Functional Anatomy ◽  
Off Label ◽  
Practical Guide ◽  
Facial Muscles ◽  
Facial Esthetics ◽  
The Face ◽  
Release Of Acetylcholine ◽  
Botulinum Toxin Injections

Botulinum toxin is a corner stone in the facial esthetics. It has been used for decades for various medical and esthetic indications. Botulinum toxin is a neurotoxin that interferes with the transmission at the neuromuscular/neurosecretory junctions by inhibiting the release of acetylcholine. An in depth knowledge of the functional anatomy of facial muscles is required to obtain the best results of the botulinum toxin injections. In this book chapter, a detailed practical guide for the FDA approved and the off label uses of botulinum toxin in the face is presented. The recently developed new indications are listed. The lengthy experience with botulinum toxin injections has proved safety and tolerability of the procedure; however, the probable complications, and steps for their prevention and management are highlighted.

Russian Banking System under Conditions of Global Crisis

2009 ◽  
pp. 4-14 ◽  
Author(s):  
G. Gref ◽  
K. Yudaeva
Keyword(s):  
Banking System ◽  
Commodity Prices ◽  
Financial Sector ◽  
Banking Crises ◽  
Economic Recovery ◽  
Balance Sheets ◽  
Current Economic Crisis ◽  
Risk Appetite ◽  
The Us ◽  
The Face

Problems in the financial sector were at the core of the current economic crisis. Therefore, economic recovery will only become sustainable after taking care of the major weaknesses in the financial sector. This conclusion is relevant both for the US and UK - the two countries where crisis has started, and for other economies which financial institutions turned out to be fragile in the face of the swings in the risk appetite. Russia is one of the countries where the crisis has revealed serious deficiency in the financial sector. Our study of 11 banking crises during the last 25-30 years shows that sustainable economic recovery and decrease in the dependence on commodity prices will be virtually impossible without cleaning of balance sheets and capitalization of the financial sector.

Too WEIRD, Too Fast: Preprints about COVID-19 in the Psychological Sciences

2020 ◽  
Author(s):  
Arathy Puthillam
Keyword(s):  
Overwhelming Majority ◽  
Global Pandemic ◽  
The Us ◽  
The World ◽  
The Face ◽  
Conducting Research ◽  
Psychological Studies

That American and European participants are overrepresented in psychological studies has been previously established. In addition, researchers also often tend to be similarly homogenous. This continues to be alarming, especially given that this research is being used to inform policies across the world. In the face of a global pandemic where behavioral scientists propose solutions, we ask who is conducting research and on what samples. Forty papers on COVID-19 published in PsyArxiV were analyzed; the nationalities of the authors and the samples they recruited were assessed. Findings suggest that an overwhelming majority of the samples recruited were from the US and the authors were based in US and German institutions. Next, men constituted a large proportion of primary and sole authors. The implications of these findings are discussed.

In vitro and in vivo Assessment of Silver Nanoparticles Against Clostridium botulinum Type A Botulinum

2019 ◽  
Vol 16 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Mohammad Aminianfar ◽  
Siavash Parvardeh ◽  
Mohsen Soleimani
Keyword(s):  
Silver Nanoparticles ◽  
Botulinum Toxin ◽  
Clostridium Botulinum ◽  
Lethal Dose ◽  
Type A ◽  
Positive Control ◽  
Negative Control ◽  
Laboratory Animals ◽  
Control Group ◽  
Nano Silver

Background: Clostridium botulinum causes botulism, a serious paralytic illness that results from the ingestion of a botulinum toxin. Because silver nanoparticle products exhibit strong antimicrobial activity, applications for silver nanoparticles in healthcare have expanded. Therefore, the objective of the current study was to assess a therapeutic strategy for the treatment of botulism toxicity using silver nanoparticles. Methods: A preliminary test was conducted using doses that produce illness in laboratory animals to determine the absolute lethal dose (LD100) of botulinum toxin type A (BoNT/A) in mice. Next, the test animals were divided into six groups containing six mice each. Groups I, II and III were the negative control (botulinum toxin only), positive control-1 (nano-silver only) and positive control-2 (no treatment), respectively. The remaining groups were allocated to the toxin that was supplemented with three nano-silver treatments. Results: The mortality rates of mice caused by BoNT/A significantly reduced in the treatment groups with different doses and injection intervals of nano-silver when compared to the negative control group. BoNT/A toxicity induced by intraperitoneal injection of the toxin of Clostridium botulinum causes rapid death while when coupled with nano-osilver results in delayed death in mice. Conclusion: These results, while open to future improvement, represent a preliminary step towards the satisfactory control of BoNT/A with the use of silver nanoparticles for human protection against this bioterrorism threat. Further study in this area can elucidate the underlying mechanism for detoxifying BoNT/A by silver nanoparticles.

The Prosperity Paradox

2020 ◽  
Author(s):  
Philip Martin
Keyword(s):  
Food Safety ◽  
Fruits And Vegetables ◽  
Agricultural Sector ◽  
Farm Workers ◽  
Farm Labor ◽  
Labor Laws ◽  
New Era ◽  
Labor Policies ◽  
The Us ◽  
Vulnerable Workers

Why do farm workers become more vulnerable as countries get richer? As countries get richer, the share of workers employed in agriculture falls. In richer countries, hired farm workers do ever more of the work on the fewer and larger farms that produce most farm commodities. These hired workers include local workers who lack the skills and contacts needed to get nonfarm jobs that usually offer higher wages and more opportunities as well as legal and unauthorized migrants from poorer countries who may not know or exercise their labor-related rights. Government enforcement of labor laws depends on complaints, and vulnerable workers rarely complain. The Prosperity Paradox explains why farm-worker problems often worsen as the agricultural sector shrinks and lays out options to help vulnerable workers. Analysis of farm labor markets in the US, Mexico, and other countries shows that unions and fair trade efforts to protect farm workers cover a very small share of all workers and are unlikely to expand quickly. Most labor-intensive fruits and vegetables are eaten fresh. Unsafe food that sickened consumers led to voluntary industry and later government-mandated food-safety programs to ensure that food is safe when it leaves the farm, with protocols enforced by both government inspectors and buyers who refused to buy from noncompliant farms. This food-safety model offers the most promise for a new era in protective labor policies.

scholarly journals FDA Approvals and Consensus Guidelines for Botulinum Toxins in the Treatment of Dystonia

Toxins ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 332 ◽  
Author(s):  
Lauren L. Spiegel ◽  
Jill L. Ostrem ◽  
Ian O. Bledsoe
Keyword(s):  
Botulinum Toxin ◽  
Literature Review ◽  
American Academy ◽  
Practice Guidelines ◽  
European Federation ◽  
Botulinum Toxins ◽  
Consensus Guidelines ◽  
Off Label ◽  
Fda Approval ◽  
American Academy Of Neurology

In 2016, the American Academy of Neurology (AAN) published practice guidelines for botulinum toxin (BoNT) in the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache. This article, focusing on dystonia, provides context for these guidelines through literature review. Studies that led to Food and Drug Administration (FDA) approval of each toxin for dystonia indications are reviewed, in addition to several studies highlighted by the AAN guidelines. The AAN guidelines for the use of BoNT in dystonia are compared with those of the European Federation of the Neurological Societies (EFNS), and common off-label uses for BoNT in dystonia are discussed. Toxins not currently FDA-approved for the treatment of dystonia are additionally reviewed. In the future, additional toxins may become FDA-approved for the treatment of dystonia given expanding research in this area.

scholarly journals Botulinum Toxin in Movement Disorders: An Update

Toxins ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 42
Author(s):  
Charenya Anandan ◽  
Joseph Jankovic
Keyword(s):  
Botulinum Toxin ◽  
Movement Disorders ◽  
Neurological Disorders ◽  
Active Drug ◽  
Therapeutic Agents ◽  
Therapeutic Modality ◽  
Review Of The Literature ◽  
Pilot Studies ◽  
The Us ◽  
Novel Applications

Since its initial approval in 1989 by the US Food and Drug Administration for the treatment of blepharospasm and other facial spasms, botulinum toxin (BoNT) has evolved into a therapeutic modality for a variety of neurological and non-neurological disorders. With respect to neurologic movement disorders, BoNT has been reported to be effective for the treatment of dystonia, bruxism, tremors, tics, myoclonus, restless legs syndrome, tardive dyskinesia, and a variety of symptoms associated with Parkinson’s disease. More recently, research with BoNT has expanded beyond its use as a powerful muscle relaxant and a peripherally active drug to its potential central nervous system applications in the treatment of neurodegenerative disorders. Although BoNT is the most potent biologic toxin, when it is administered by knowledgeable and experienced clinicians, it is one of the safest therapeutic agents in clinical use. The primary aim of this article is to provide an update on recent advances in BoNT research with a focus on novel applications in the treatment of movement disorders. This comprehensive review of the literature provides a critical review of evidence-based clinical trials and highlights recent innovative pilot studies.

Innovationsmotor Medientechnik – Von der Schreibmaschine zur «Mittleren Datentechnik» bei der Siemag Feinmechanische Werke (1950 bis 1969)

2021 ◽  
Vol 66 (1) ◽  
pp. 93-117
Author(s):  
Christian Henrich-Franke
Keyword(s):  
Data Processing ◽  
New Technologies ◽  
Strategic Decisions ◽  
Adverse Conditions ◽  
Family Enterprise ◽  
The Us ◽  
Innovative Products ◽  
The Face ◽  
The Media ◽  
The 1960S

Abstract The second half of the 20th century is commonly considered to be a time in which German companies lost their innovative strength, while promising new technologies presented an enormous potential for innovation in the US. The fact that German companies were quite successful in the production of medium data technology and had considerable influence on the development of electronic data processing was neglected by business and media historians alike until now. The article analyses the Siemag Feinmechanische Werke (Eiserfeld) as one of the most important producers of the predecessors to said medium data technologies in the 1950s and 1960s. Two transformation processes regarding the media – from mechanic to semiconductor and from semiconductor to all-electronic technology – are highlighted in particular. It poses the question of how and why a middling family enterprise such as Siemag was able to rise to being the leading provider for medium data processing office computers despite lacking expertise in the field of electrical engineering while also facing difficult location conditions. The article shows that Siemag successfully turned from its roots in heavy industry towards the production of innovative high technology devices. This development stems from the company’s strategic decisions. As long as their products were not mass-produced, a medium-sized family business like Siemag could hold its own on the market through clever decision-making which relied on flexible specialization, targeted license and patent cooperation as well as innovative products, even in the face of adverse conditions. Only in the second half of the 1960s, as profit margins dropped due to increasing sales figures and office machines had finally transformed into office computers, Siemag was forced to enter cooperation with Philips in order to broaden its spectrum and merge the production site in Eiserfeld into a larger business complex.

Botulinum toxin complications in registered and off‐label aesthetic indications

2020 ◽  
Vol 19 (10) ◽  
pp. 2484-2490
Author(s):  
Marina Landau ◽  
Mark S. Nestor ◽  
Ada Trindade Almeida ◽  
Firas Al‐Niaimi
Keyword(s):  
Botulinum Toxin ◽  
Off Label
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