COMMON VARIABLE IMMUNODEFICIENCY, DEPENDENT COSTIMULATION B CELLS MOLECULES AND AUTOIMMUNE HEMATOLOGICAL DISEASES IN ADULTS.

2016 ◽  
Author(s):  
Patricia O Farrill
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Hematological Diseases ◽  
Common Variable

scholarly journals Common Variable Immunodeficiency / Cvid

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Autoimmune Disorders ◽  
Common Variable

“Variable” refers to the heterogeneousclinicalmanifestations of thisdisorder, which can include: recurrentinfections, chroniclungdisease, autoimmune disorders, also involve varioussegments of the gastrointestinaltract and a heightenedsusceptibility to lymphoma. Itis a primaryimmunodeficiencythataffects 1 in 50,000 peopleworldwide. Itischaracterized by reducedimmunoglobulinserumlevels and absent or impairedantibody production. The pathogenic of CVID isnotknown; however, therehavebeennumerousassociatedlaboratoryfindingsincludingnumerousmutations in the genesresult in dysfunctional B cells. The mostfrequentmutationsoccur in the TNFRSF13B gene. Genesthathavebeenimplicated in monogenic CVID include ICOS, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF12 (TWEAK), CD19, CD81, CR2 (CD21), MS4A1 (CD20), TNFRSF7 (CD27), IL21, IL21R, LRBA, CTLA4, PRKCD, PLCG2, NFKB1, NFKB2, PIK3CD, PIK3R1, VAV1, RAC2, BLK, IKZF1 (IKAROS) and IRF2BP2 [1]. In addition, thereisevidence of complexinheritanceratherthan a monogenic CVID.

Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21low B cells

2019 ◽  
Vol 47 (5) ◽  
pp. 457-466 ◽  
Author(s):  
G. López-Herrera ◽  
N.H. Segura-Méndez ◽  
P. O’Farril-Romanillos ◽  
M.E. Nuñez-Nuñez ◽  
M.C. Zarate-Hernández ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Regulatory T Cells ◽  
Autoimmune Diseases ◽  
Common Variable Immunodeficiency ◽  
Common Variable

scholarly journals Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

2009 ◽  
Vol 106 (32) ◽  
pp. 13451-13456 ◽  
Author(s):  
M. Rakhmanov ◽  
B. Keller ◽  
S. Gutenberger ◽  
C. Foerster ◽  
M. Hoenig ◽  
...  
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Common Variable

Impaired Akt phosphorylation in B-cells of patients with common variable immunodeficiency

2017 ◽  
Vol 175 ◽  
pp. 124-132 ◽  
Author(s):  
Reza Yazdani ◽  
Mazdak Ganjalikhani-Hakemi ◽  
Mohammad Esmaeili ◽  
Hassan Abolhassani ◽  
Shahram Vaeli ◽  
...  
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Akt Phosphorylation ◽  
Common Variable

scholarly journals 604 Phenotypic and Functional Analysis of B Cells in Patients with Common Variable Immunodeficiency

2012 ◽  
Vol 5 ◽  
pp. S191
Author(s):  
Laura Berrón-Ruiz ◽  
Dolores Mogica Martínez ◽  
Leopoldo Santos-Argumedo ◽  
Gabriela López Herrera ◽  
Francisco Espinosa-Rosales ◽  
...  
Keyword(s):  
Functional Analysis ◽  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Common Variable
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