THE EFFECTIVENESS OF ALBENDAZOLE PLUS VITAMIN A VERSUS ALBENDAZOLE PLUS PLACEBO IN PREVENTING ASCARIS LUMBRICOIDES RE-INFECTION IN SCHOOL-AGE CHILDREN: A DOUBLE BLIND RANDOMIZED CONTROLLED TRIAL

Author(s):  
Inke Nadia Diniyanti Lubis
2013 ◽  
Vol 83 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Endy P. Prawirohartono ◽  
Lennarth Nyström ◽  
Detty S. Nurdiati ◽  
Mohammad Hakimi ◽  
Torbjörn Lind

Background: Prenatal supplementation with micronutrients may increase birth weight and thus improve infant health and survival in settings where infants and children are at risk of micronutrient deficiencies. Objective: To assess whether vitamin A and/or zinc supplementation given during pregnancy can improve birth weight, birth length, neonatal morbidity, or infant mortality. Methods: A double-blind, randomized controlled trial supplementing women (n = 2173) in Central Java, Indonesia throughout pregnancy with vitamin A, zinc, combined vitamin A+zinc, or placebo. Results: Out of 2173 supplemented pregnant women, 1956 neonates could be evaluated. Overall, zinc supplementation improved birth length compared to placebo or combined vitamin A+zinc (48.8 vs. 48.5 cm, p = 0.04); vitamin A supplementation improved birth length compared to placebo or combined vitamin A+zinc (48.7 vs. 48.2 cm, p = 0.04). These effects remained after adjusting for maternal height, pre-pregnancy weight, and parity. There was no effect of supplementation on birth weight, the proportion of low birth weight, neonatal morbidity, or mortality. Conclusions: Prenatal zinc or vitamin A supplementation demonstrates a small but significant effect on birth length, but supplementation with zinc, vitamin A or a combination of zinc and vitamin A, have no effect on birth weight, neonatal morbidity, or mortality.


2015 ◽  
Vol 58 (4) ◽  
pp. 1258-1272 ◽  
Author(s):  
Carol K. S. To ◽  
Hoi Ming Lui ◽  
Xin Xin Li ◽  
Gary Y. H. Lam

Purpose In this study, we aimed to evaluate the efficacy of sentence-combining (SC) and narrative-based (NAR) intervention approaches to syntax intervention using a randomized-controlled-trial design. Method Fifty-two Cantonese-speaking, school-age children with language impairment were assigned randomly to either the SC or the NAR treatment arm. Seven children did not receive treatment as assigned. Intervention in both arms targeted the same complex syntactical structures. The SC group focused on sentence combination training, whereas the NAR group made use of narratives in which the target structures were embedded. Pretest and posttest performances measured using a standardized language assessment were subjected to analyses of covariance mixed-effect-model analyses of variance. Results Children in both treatment arms demonstrated significant growth after 4 months of intervention. The main effect between treatment arms and time was not significant after controlling the pretest performance, suggesting that both treatment approaches showed similar effects. The main effect of time was significant. Conclusions This study provided evidence to support language intervention in the school years in Cantonese-speaking children. However, neither approach was shown to be more efficacious than the other. Future researchers could examine the effects of a longer treatment period and include functional outcome measures.


Vaccine ◽  
2013 ◽  
Vol 31 (15) ◽  
pp. 1937-1943 ◽  
Author(s):  
Brendan Klick ◽  
Sunita Durrani ◽  
Kwok-Hung Chan ◽  
Dennis K.M. Ip ◽  
Erica S.K. Chou ◽  
...  

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