Interfollicular Hodgkin's lymphoma: A diagnostic dilemma

2017 ◽  
Author(s):  
Marwa Guerfala
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Diagnostic Dilemma

scholarly journals Interfollicular Hodgkin's Lymphoma - A Diagnostic Dilemma

2012 ◽  
Vol 11 (3) ◽  
pp. 241-247
Author(s):  
S Zeeba ◽  
R Safia ◽  
SC Pradeep ◽  
S Shruti ◽  
K Sujala
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Benign Lesion ◽  
Medical Science ◽  
Hodgkin's Lymphoma ◽  
Diagnostic Dilemma ◽  
Follicular Hyperplasia ◽  
Reactive Change ◽  
Unusual Pattern

Interfollicular Hodgkin's lymphoma represents an unusual pattern of focal involvement of interfollicular zones by Hodgkin's lymphoma along with florid reactive follicular hyperplasia. It is often mistakenly diagnosed as a reactive change. We report a case of a 36 years old male with persistent lymphadenitis for three years, who was finally diagnosed as Interfollicular Hodgkin's lymphoma after being incorrectly diagnosed as reactive lymphadenitis. This case is reported in view of the unusual pattern of Hodgkin's lymphoma as well as its misdiagnosis as a benign lesion. DOI: http://dx.doi.org/10.3329/bjms.v11i3.11739 Bangladesh Journal of Medical Science Vol. 11 No. 03 July’12

scholarly journals Diagnostic dilemma of Hodgkin’s lymphoma versus tuberculosis: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Anamika Banerjee ◽  
Kaljit Bhuller ◽  
Rajini Sudhir ◽  
Amrita Bajaj
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Incidental Finding ◽  
White Cell Count ◽  
Diagnostic Delay ◽  
Stage Iv ◽  
Hodgkin's Lymphoma ◽  
Molecular Testing ◽  
Ethical Guidelines ◽  
Diagnostic Dilemma ◽  
Smear Negative

Abstract Background Hodgkin’s Lymphoma (HL) is a rare malignancy characterised histologically by the presence of Reed-Sternberg cells. Diagnosis of lymphomas can be difficult due to broad, non-specific presentations of disease, which can be similar to several other conditions ranging from infective, inflammatory or malignant causes, with one of the most common differentials being tuberculosis (TB). We aim to highlight the diagnostic dilemma of TB versus lymphoma with an atypical presentation of HL and explored areas for further research and improvement with a non-systematic literature review using MEDLINE database and Google Scholar. Written consent was obtained from the patient in compliance with ethical guidelines. Case presentation A 23-year-old Asian female initially presented to rheumatology with over a one-year history of neuropathic pain, alongside abnormal white cell count and inflammatory markers. This was investigated with magnetic resonance imaging resulting in an incidental finding of mediastinal mass and pulmonary infiltrates. An initial diagnosis of TB was made despite testing negative for acid-fast bacilli and anti-tubercular treatment was commenced. Four months later, following clinical deterioration and further investigations, a mediastinal biopsy assisted in diagnosing Stage IV HL. Conclusions Lymphoma is often misdiagnosed as TB, prolonging time to treatment and may adversely impact patient prognosis due to disease progression. Existing TB guidelines for smear-negative cases are not clear when to consider alternative diagnoses. In smear-negative TB, lymphoma should be considered as a differential and definitive diagnostic tests such as molecular testing and histological examination of biopsies should be considered earlier in the diagnostic work-up to prevent diagnostic delay.

Evaluation of Bone Marrow Trephine Biopsy: 134 Cases Over 8 Years -A Single Centre Experience

2018 ◽  
Vol 2 (02) ◽  
pp. 47-50
Author(s):  
Amin Lutful Kabir ◽  
Sayed Salahuddin Ahmed ◽  
Munim Ahmed ◽  
Md. Abdul Aziz ◽  
ASM Anwarul Kabir ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hodgkin’S Lymphoma ◽  
Bone Marrow Involvement ◽  
Prognostic Significance ◽  
Hodgkin's Lymphoma ◽  
Trephine Biopsy ◽  
Diagnostic Dilemma ◽  
College Hospital ◽  
Bone Marrow Trephine ◽  
Haematological Disorders

Background: Trephine biopsy is a core biopsy of bone marrow using a special needle to evaluate the marrow architecture. Taking bone marrow biopsy alongside aspirate is still the most preferred practice for precise diagnosis and evaluation of various haematological and non- haematological disorders. Aims and objective: This study was carried out to evaluate the importance of this procedure in the diagnosis of various haematological and non-haematological disorders especially when bone marrow aspirates alone are non-diagnostic and to assess the prognostic significance of haematological malignancy. Materials and Methods: This was a retrospective study using the trephine biopsy and aspiration reports extracted from hospital records of Delta Medical College Hospital, Dhaka, over an 8years period from May 2009 to December 2016.The patient's profiles along with corresponding diagnoses and the necessary investigation reports were analysed. Result: Eighteen (26.47%) patients had bone marrow involvement for non-Hodgkin's lymphoma, three (4.41%) patients for Hodgkin's lymphoma, and acute lymphoblastic leukaemia was diagnosed in 18 (13.43%) patients, metastatic deposits in 6 (4.5%) patients, acute promyelocytic leukaemia in 3 (2.2%) cases, aplastic anaemia in 7 (5.2%) cases, chronic lymphocytic leukaemia in 1 (0.75%) case, multiple myeloma in 3 (2.2%) cases, myelofibrosis in 6 (4.5%) cases and chronic myeloid leukaemia and immune thrombocytopenic purpura were found in less than 1% cases. Total 37 patients (54.41 %) were reported as normocellular marrow with normal maturation among all the cases of lymphomas (N=68). One trephine biopsy was carried out to assess remission after induction chemotherapy in ALL. Conclusion: Trephine biopsy is an invaluable diagnostic tool in case of diagnostic dilemma and for follow up of patients undergoing chemotherapy and bone marrow transplantation. An expert haematopathological evaluation of the bone marrow trephine can impart light on actual diagnosis and have tremendous impact regarding patient management. 

NODULAR SCLEROSIS HOGDKINS LYMPHOMA GRADE 2 MIMICKING ANAPLASTIC LARGE CELL LYMPHOMA - A CASE REPORT

2021 ◽  
pp. 72-73
Author(s):  
Neelam Sood ◽  
Shikha Chopra
Keyword(s):  
Lymph Node ◽  
Hodgkin’S Lymphoma ◽  
Giant Cells ◽  
Hodgkin's Lymphoma ◽  
Classical Type ◽  
Diagnostic Dilemma ◽  
Atypical Cell ◽  
Cervical Lymph Nodes ◽  
Nodular Sclerosis ◽  
Multinucleated Cells

INTRODUCTION: Hodgkin's lymphoma (HL) is a lymphoproliferative neoplasm constituting less than 1% of all neoplasms. It has been categorized into- nodular lymphocyte predominant HL and classical type with subtypeslymphocyte rich, lymphocyte depleted, nodular sclerosis and mixed cellularity. Nodular sclerosis Hodgkin's lymphoma (NSHL) is difcult to diagnose on FNA because of the lack of Reed Sternberg (RS) cells, low cellularity and difculty in identifying the counterpart of lacunar cells. CASE A 16-year-old female presented with anterior chest wall swelling si REPORT: nce 6 months measuring 5x4cm along with incidentally noted cervical lymph nodes measuring 2x2cm and 1x1cm. On examination, multiple papular skin lesions were observed. FNAC smears from cervical lymph node showed high cellularity, with sheets of binucleated and multinucleated cells having multiple nucleoli, some showing pale bluish abundant cytoplasm whereas others showing dense cytoplasm; in a background of reactive lymphoid population with few neutrophils. Few giant cells showed hyperchromatic nuclei. Abnormal mitosis seen. No typical RS cell was seen. Peripheral blood smear showed neutrophilic leukocytosis with no atypical cell. Possibility of NSHL was considered and biopsy advised to rule out ALCL. Histological sections showed near total effacement of lymph node architecture by nodules separated by broad brotic bands. These nodules exhibit proliferating lymphocytes with clustered lacunar cells along with some mononucleate, binucleate and multinucleated cells. Prominent mitotic activity, angiogenesis, focal micro abscesses were noted. Immunohistochemistry showed CD 15+ and CD 30+ expression in the giant cells, conrming diagnosis of NSHL grade 2. NSHL poses a cytological diagnostic dilemma specially in abse CONCLUSION: nce of sclerosis on FNA, making histological examination and IHC mandatory

Sexual Functioning in Long-Term Survivors of Hodgkin's Lymphoma

2008 ◽  
Author(s):  
Veronica Sanchez Varela ◽  
Sharon Bober ◽  
Andrea Ng ◽  
Peter Mauch ◽  
Christopher Recklitis
Keyword(s):  
Sexual Functioning ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Long Term Survivors
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