scholarly journals 06 / Prevalence of postoperative nausea and vomiting: the reality of our Ambulatory Surgery Unit – retrospective analysis

Author(s):  
Jânia Pacheco ◽  
João Galacho
2014 ◽  
Vol 6 (1) ◽  
pp. 52 ◽  
Author(s):  
Anjan Das ◽  
Saikat Majumdar ◽  
Tapobrata Mitra ◽  
Ratul Kundu ◽  
Tapas Bhattacharyya ◽  
...  

1995 ◽  
Vol 82 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Mehernoor F. Watcha ◽  
Paul J. Bras ◽  
Gary D. Cieslak ◽  
John H. Pennant

Background Postoperative nausea and vomiting is a distressing anesthetic complication that may delay discharge after ambulatory surgery. Effective prophylaxis for postoperative nausea and vomiting can be achieved in adults with lower doses of ondansetron, a 5-hydroxytryptamine subtype 3 receptor antagonist, compared with chemotherapy-induced emesis. However, the doses of ondansetron used in preventing postoperative nausea and vomiting in children are based on data from chemotherapy-induced emesis. The dose-related efficacy of intravenous ondansetron in the prophylaxis of postoperative emesis in the pediatric outpatient population was determined. Methods In a double-blind, randomized placebo-controlled study, 130 patients (mean age 5.7 +/- 3.4 yr) received placebo, 10, 50, or 100 micrograms/kg ondansetron during a standardized anesthetic. Episodes of postoperative vomiting or retching were recorded. Results Intravenous ondansetron in a dose of 50 micrograms/kg was more effective than placebo or a dose of 10 micrograms/kg in controlling the incidence and frequency of emesis in the hospital and during the first 24 postoperative hours. Increasing the dose of ondansetron to 100 micrograms/kg intravenously did not significantly reduce the incidence or frequency of emesis compared to 50 micrograms/kg intravenously. Conclusions Intravenous ondansetron in a dose of 50 micrograms/kg is as effective as larger doses for the prophylaxis of emesis in children undergoing surgical procedures known to be associated with an increased risk for postoperative nausea and vomiting.


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