scholarly journals A Nanodiamond-Based Theranostic Agent for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing

2020 ◽  
Author(s):  
Yingke Wu ◽  
Md Noor A Alam ◽  
Priyadharshini Balasubramanian ◽  
Anna Ermakova ◽  
Stefan Fischer ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Biological Activities ◽  
Local Effect ◽  
Biological Processes ◽  
Essential Factor ◽  
Non Invasive ◽  
Theranostic Agent ◽  
External Conditions ◽  
Fluorescent Nanodiamonds ◽  
High Control

Temperature is an essential factor in all biological processes and most of the biological activities are related to temperature. However, information about the temperature in living cells are limited. In photothermal therapy, an emerging cancer treatment due to its high spatial control and non-invasive nature, the local effect of intracellular temperature change is not well understood. Fluorescent nanodiamonds (ND) are a unique carbon material possessing optical defects inside the carbon lattice that enable sensing of temperature on a nanoscale completely independent of external conditions. Herein, we coat ND with polymers to form a nanogel shell around NDs that can absorb indocyanine green, a common photothermal agent, to obtain nanodiamond-nanogel-indocyanine green. Upon irradiation, we not only show successful killing of cancer cells with a high control in space but we are also able to sense the increase in temperature using single NDs as nanothermometers in cells.<br>

scholarly journals A Nanodiamond-Based Theranostic Agent for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing

2020 ◽  
Author(s):  
Yingke Wu ◽  
Md Noor A Alam ◽  
Priyadharshini Balasubramanian ◽  
Anna Ermakova ◽  
Stefan Fischer ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Biological Activities ◽  
Local Effect ◽  
Biological Processes ◽  
Essential Factor ◽  
Non Invasive ◽  
Theranostic Agent ◽  
External Conditions ◽  
Fluorescent Nanodiamonds ◽  
High Control

Temperature is an essential factor in all biological processes and most of the biological activities are related to temperature. However, information about the temperature in living cells are limited. In photothermal therapy, an emerging cancer treatment due to its high spatial control and non-invasive nature, the local effect of intracellular temperature change is not well understood. Fluorescent nanodiamonds (ND) are a unique carbon material possessing optical defects inside the carbon lattice that enable sensing of temperature on a nanoscale completely independent of external conditions. Herein, we coat ND with polymers to form a nanogel shell around NDs that can absorb indocyanine green, a common photothermal agent, to obtain nanodiamond-nanogel-indocyanine green. Upon irradiation, we not only show successful killing of cancer cells with a high control in space but we are also able to sense the increase in temperature using single NDs as nanothermometers in cells.<br>

scholarly journals A Nanodiamond-Based Theranostic Agent for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing

2020 ◽  
Author(s):  
Yingke Wu ◽  
Md Noor A Alam ◽  
Priyadharshini Balasubramanian ◽  
Anna Ermakova ◽  
Stefan Fischer ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Biological Activities ◽  
Local Effect ◽  
Biological Processes ◽  
Essential Factor ◽  
Non Invasive ◽  
Theranostic Agent ◽  
External Conditions ◽  
Fluorescent Nanodiamonds ◽  
High Control

Temperature is an essential factor in all biological processes and most of the biological activities are related to temperature. However, information about the temperature in living cells are limited. In photothermal therapy, an emerging cancer treatment due to its high spatial control and non-invasive nature, the local effect of intracellular temperature change is not well understood. Fluorescent nanodiamonds (ND) are a unique carbon material possessing optical defects inside the carbon lattice that enable sensing of temperature on a nanoscale completely independent of external conditions. Herein, we coat ND with polymers to form a nanogel shell around NDs that can absorb indocyanine green, a common photothermal agent, to obtain nanodiamond-nanogel-indocyanine green. Upon irradiation, we not only show successful killing of cancer cells with a high control in space but we are also able to sense the increase in temperature using single NDs as nanothermometers in cells.<br>

Electrical Capacitance Volume Tomography (ECVT) for industrial and medical applications-An Overview

2015 ◽  
Vol 11 (1) ◽  
pp. 2897-2908
Author(s):  
Mohammed S.Aljohani
Keyword(s):  
Imaging Technique ◽  
Three Dimensional ◽  
Biological Processes ◽  
Electrical Capacitance ◽  
Image Reconstruction Techniques ◽  
Phase Dynamics ◽  
Non Invasive ◽  
Electrical Capacitance Volume Tomography ◽  
And Performance ◽  
Optimization And Performance

Tomography is a non-invasive, non-intrusive imaging technique allowing the visualization of phase dynamics in industrial and biological processes. This article reviews progress in Electrical Capacitance Volume Tomography (ECVT). ECVT is a direct 3D visualizing technique, unlike three-dimensional imaging, which is based on stacking 2D images to obtain an interpolated 3D image. ECVT has recently matured for real time, non-invasive 3-D monitoring of processes involving materials with strong contrast in dielectric permittivity. In this article, ECVT sensor design, optimization and performance of various sensors seen in literature are summarized. Qualitative Analysis of ECVT image reconstruction techniques has also been presented.

Clearance and Non-Invasive Determination of the Hepatic Extraction of Indocyanine Green in Baboons and Man

1983 ◽  
Vol 64 (2) ◽  
pp. 207-212 ◽  
Author(s):  
S. L. Grainger ◽  
P. W. N. Keeling ◽  
I. M. H. Brown ◽  
J. H. Marigold ◽  
R. P. H. Thompson
Keyword(s):  
Indocyanine Green ◽  
Accurate Determination ◽  
Liver Blood Flow ◽  
Compartment Model ◽  
Hepatic Extraction ◽  
Non Invasive ◽  
Two Compartment Model ◽  
Hepatic Extraction Ratio ◽  
Plasma Disappearance Curve

1. The disposition of an intravenous bolus of indocyanine green (ICG) has been studied in healthy man and baboons using a novel analysis of a two compartment pharmacokinetic model. 2. This analysis enabled the hepatic extraction ratio (ER) of dye to be determined solely from the plasma disappearance curve, and the ER determined did not differ from that measured by hepatic vein catheterization. 3. When compared with clearance measured at steady state, the two compartment model gave a significantly more accurate determination of plasma clearance than did the conventional one compartment model. 4. It is concluded that, in health, liver blood flow may be calculated accurately and noninvasively after a single intravenous injection of ICG.

scholarly journals Nano-loaded natural killer cells as carriers of indocyanine green for synergetic cancer immunotherapy and phototherapy

2019 ◽  
Vol 12 (03) ◽  
pp. 1941002 ◽  
Author(s):  
Shigao Huang ◽  
Chi Ian Fong ◽  
Mengze Xu ◽  
Bing-nan Han ◽  
Zhen Yuan ◽  
...  
Keyword(s):  
Side Effects ◽  
Natural Killer Cells ◽  
Indocyanine Green ◽  
Cancer Treatment ◽  
Nk Cells ◽  
Cancer Immunotherapy ◽  
Natural Killer ◽  
Therapeutic Options ◽  
Theranostic Agent ◽  
Cancer Theranostics

To improve the efficacy of traditional chemotherapy and radiotherapy and reduce their serious side effects, further efforts need to be exerted to identify better cancer therapeutic options that are effective, affordable, and acceptable to patients. In this study, a novel theranostic agent was produced to perform synergetic cancer immunotherapy and phototherapy. The theranostic agent, named natural killer (NK) cells carrying indocyanine green loaded liposomes was synthesized NK cells with ICG nanoparticles to serve as the agent for a newly-established cancer treatment. It is expected that the developed synergistic therapy can pave a new avenue for improved efficacy of cancer theranostics.

scholarly journals The indocyanine green retention test as a non-invasive marker for esophageal varices in patients with hepatocellular carcinoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hsiao-Sheng Lu ◽  
I-Fang Hsin ◽  
Ping-Hsien Chen ◽  
Tsung-Chieh Yang ◽  
Chung-Yu Chang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Esophageal Varices ◽  
Retention Test ◽  
Non Invasive

scholarly journals Herb Network Analysis for a Famous TCM Doctor's Prescriptions on Treatment of Rheumatoid Arthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yan Li ◽  
Rui Li ◽  
Zibo Ouyang ◽  
Shao Li
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Biological Activities ◽  
Network Pharmacology ◽  
Biological Processes ◽  
Hormone Regulation ◽  
The Core ◽  
Target Disease ◽  
Herbal Formulae ◽  
Target Sets

Traditional Chinese Medicine (TCM) doctors always prescribe various herbal formulae tailored to individual patients. However, there is still a lack of appropriate methods to study the rule and potential biological basis underlying the numerous prescriptions. Here we developed an Herb-Compound-Target-Disease coherent network approach to analyze 871 herbal prescriptions from a TCM master, Mr. Ji-Ren Li, in his clinical practice on treatment of rheumatoid arthritis (RA). The core herb networks were extracted from Mr. Li’s prescriptions. Then, we predicted target profiles of compounds in core herb networks and calculated potential synergistic activities among them. We further found that the target sets of core herbs overlapped significantly with the RA related biological processes and pathways. Moreover, we detected a possible connection between the prescribed herbs with different properties such as Cold and Hot and the Western drugs with different actions such as immunomodulatory and hormone regulation on treatment of RA. In summary, we explored a new application of TCM network pharmacology on the analysis of TCM prescriptions and detected the networked core herbs, their potential synergistic and biological activities, and possible connections with drugs. This work offers a novel way to understand TCM prescriptions in clinical practice.

scholarly journals Essential Oils and Isolated Terpenes in Nanosystems Designed for Topical Administration: A Review.

Biomolecules ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 138 ◽  
Author(s):  
Sheila P. de Matos ◽  
Helder F. Teixeira ◽  
Ádley A. N. de Lima ◽  
Valdir F. Veiga-Junior ◽  
Letícia S. Koester
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Molecular Complexes ◽  
Topical Administration ◽  
Chemical Degradation ◽  
Current Status ◽  
Permeation Enhancers ◽  
Non Invasive ◽  
Nanostructured Systems ◽  
Systemic Drug Delivery

Essential oils are natural products with a complex composition. Terpenes are the most common class of chemical compounds present in essential oils. Terpenes and the essential oils containing them are widely used and investigated by their pharmacological properties and permeation-enhancing ability. However, many terpenes and essential oils are sensitive to environmental conditions, undergoing volatilization and chemical degradation. In order to overcome the chemical instability of some isolated terpenes and essential oils, the encapsulation of these compounds in nanostructured systems (polymeric, lipidic, or molecular complexes) has been employed. In addition, nanoencapsulation can be of interest for pharmaceutical applications due to its capacity to improve the bioavailability and allow the controlled release of drugs. Topical drug administration is a convenient and non-invasive administration route for both local and systemic drug delivery. The present review focuses on describing the current status of research concerning nanostructured delivery systems containing isolated terpenes and/or essential oils designed for topical administration and on discussing the use of terpenes and essential oils either for their biological activities or as permeation enhancers in pharmaceutic formulations.

scholarly journals A System-Level Investigation into the Mechanisms of Apigenin Against Inflammation

2019 ◽  
Vol 14 (9) ◽  
pp. 1934578X1987860 ◽  
Author(s):  
Ying Xie ◽  
Dongdong Liang ◽  
Qingke Wu ◽  
Xuemei Chen ◽  
Manal Ali Buabeid ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Biological Activities ◽  
Enrichment Analysis ◽  
Underlying Mechanism ◽  
Mitogen Activated Protein Kinase ◽  
System Level ◽  
Network Pharmacology ◽  
Pathway Enrichment Analysis ◽  
Biological Processes ◽  
Go Terms

Apigenin is a natural flavone that possesses excellent biological activities especially against aging and cancer. However, the underlying mode of its action is not yet revealed. The purpose of this study was to examine the pharmacological mechanisms of apigenin using the knowledge of network pharmacology, protein-protein interaction (PPI) databases and biological processes analysis through Cytoscape. Apigenin targets were retrieved through PASS Prediction and STITCH database and the interactive associations between these targets were studied using STITCH, followed by GO (gene ontology) and pathway enrichment analysis. As a result of target search, 125 protein targets were retrieved. Moreover, 216 GO terms related to various biological processes, 16 GO terms for various molecular processes, 5 GO terms for the cellular components, and 52 Kyoto Encyclopedia of Genes and Genomes pathway terms were achieved by analyzing gene functional annotation clusters and abundance values of these targets. Most of these terms are strongly associated with inflammation through various pathways, for example, FOXO, mammalian target of rapamycin, tumor necrosis factor, p53, AMP-activated protein kinase, p13K-AKT, and mitogen-activated protein kinase, which play an important role in inflammation, aging and cancer. Apigenin can be used to treat inflammation, aging, and cancer with an underlying mechanism of inflammation suppression. This study contributed excellent information for a better understanding of the modes of action of apigenin. However, further studies such as docking and MD simulation are required to understand the therapeutic and toxicological roles of these targets of apigenin.

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